Budesonide/formoterol decreases expression of vascular endothelial growth factor (VEGF) and VEGF receptor 1 within airway remodelling in asthma

Advances in Therapy

Volumn 25, Issue 4, 2008, Pages 342-354

  Wang, Ke ^a   Liu, Chun Tao ^a   Wu, Yong Hong ^a   Feng, Yu Ling ^a   Bai, Hong li ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Airway remodelling; Asthma; Vascular endothelial growth factor; Vascular endothelial growth factor receptor 1

Indexed keywords

BUDESONIDE PLUS FORMOTEROL; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; ANTIASTHMATIC AGENT; BUDESONIDE; CORTICOSTEROID; ETHANOLAMINE DERIVATIVE; VASCULOTROPIN A;

ADULT; AIRWAY OBSTRUCTION; AIRWAY REMODELLING; ANGIOGENESIS; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; EPITHELIUM CELL; FEMALE; FORCED EXPIRATORY VOLUME; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; LUNG FIBROSIS; MALE; MICROVASCULARIZATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; TREATMENT DURATION; BIOSYNTHESIS; BRONCHUS; DRUG COMBINATION; DRUG EFFECT; LUNG FUNCTION TEST; METABOLISM; MIDDLE AGED; NEOVASCULARIZATION (PATHOLOGY); PATHOLOGY;

ADRENAL CORTEX HORMONES; ADULT; ANTI-ASTHMATIC AGENTS; ASTHMA; BRONCHI; BUDESONIDE; DRUG COMBINATIONS; ETHANOLAMINES; FEMALE; HUMANS; MALE; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; RESPIRATORY FUNCTION TESTS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 58149352854     PISSN: 0741238X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12325-008-0048-4     Document Type: Article

References (40)

1. Busse WW, Banks-Schlegel S, Wenzel SE. Pathophysiology of severe asthma. J Allergy Clin Immunol. 2000;106:1033-1042.
2. Li X, Wilson JW. Increased vascularity of the bronchial mucosa in mild asthma. Am J Respir Crit Care Med. 1997;156:229-233.
3. Orsida BE, Ward C, Li X, et al. Effect of a long-acting α2-agonist over three months on airway wall vascular remodeling in asthma. Am J Respir Crit Care Med. 2001;164:117-121.
4. Richter A, Puddicombe SM, Lordan JL, et al. The contribution of interleukin (IL)-4 and IL-13 to the epithelial mesenchymal trophic unit in asthma. Am J Respir Cell Mol Biol. 2001;25:385-391.
5. Davies DE, Wicks J, Powell RM, Puddicombe SM, Holgate ST. Airway remodeling in asthma: New insights. J Allergy Clin Immunol. 2003;111:215-225.
6. Chediak AD, Elsasser S, Ceste ME, Gazeroglu H, Wanner A. Effect of histamine on tracheal mucosal perfusion, water content and airway smooth muscle in sheep. Respir Physiol. 1991;84:231-243.
7. Svensjo E, Persson CG, Rutili G. Inhibition of bradykinin induced macromolecular leakage from post-capillary venules by a α2-adrenoreceptor, terbutaline. Acta Physiol Scand. 1977;101:504-506.
8. Laitinen LA, Laitinen A, Widdicombe J. Effects of inflammatory and other mediators on airway vascular beds. Am Rev Respir Dis. 1987;135:S67-S70.
9. Bjork J, Smedegard G. Acute microvascular effects of PAF-acether, as studied by intravital microscopy. Eur J Pharmacol. 1983;96:87-94.
10. McDonald DM. Neurogenic inflammation in the respiratory tract: Actions of sensory nerve mediators on blood vessels and epithelium of airway mucosa. Am Rev Respir Dis. 1987;136:S65-S72.
11. Hoshino M, Takahashi M, Aoike N. Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immunoreactivity in asthmatic airways and its relationship to angiogenesis. J Allergy Clin Immunol. 2001;107:295-301.
12. Thurston G, Murphy TJ, Baluk P, Lindsey JR, McDonald DM. Angiogenesis in mice with chronic airway inflammation: Strain-dependent differences. Am J Pathol. 1998;152:1099-1112.
13. Ferrara N. Molecular and biological properties of vascular endothelial growth factor. J Mol Med. 1999;77:527-543.
14. Detmar M, Brown LF, Schon MP, et al. Increased microvascular density and enhanced leukocyte rolling and adhension in the skin of VEGF transgenic mice. J Invest Dermatol. 1998;111:1-6.
15. Melder RJ, Koenig GC, Witwer BP, Safabakhsh N, Munn LL, Jain RK. During angiogenesis, vascular endothelial growth factor and basic fibroblast growth factor regulate natural killer cell adhesion to tumor endothelium. Nat Med. 1996;2:992-997.
16. Laitinen LA, Laitinen A. Inhaled corticosteroid treatment for asthma. Allergy Proc. 1995;16:63-66.
17. Young PG, Skinner SJ, Black PN. Effects of glucocorticoids and s-adrenoceptor agonists on the proliferation of airway smooth muscle. Eur J Pharmacol. 1995;273:137-143.
18. Li X, Ward C, Thien F, et al. An antiinflammatory effect of salmeterol, a long-acting β(2) agonist, assessed in airway biopsies and bronchoalveolar lavage in asthma. Am J Respir Crit Care Med. 1999;160:1493-1499.
19. Kips JC, O'Connor BJ, Inman MD, et al. A long-term study of the antiinflammatory effect of low-dose budesonide plus formoterol versus high-dose budesonide in asthma. Am J Respir Crit Care Med. 2000;161:996-1001.
20. Hoshino M, Nakamura Y, Sim JJ, Shimojo J, Isogai S. Bronchial subepithelial fibrosis and expression of matrix metalloproteinase-9 in asthmatic airway inflammation. J Allergy Clin Immunol. 1998;102:783-788.
21. Burgel PR, Montani D, Danel C, et al. A morphometric study of mucins and small airway plugging in cystic fibrosis. Thorax. 2007;62:153-161.
22. van den Brule S, Heymans J, Havaux X, et al. Profibrotic effect of IL-9 overexpression in a model of airway remodeling. Am J Respir Cell Mol Biol. 2007;37:202-209.
23. Morice AH, Peterson S, Beckman O, et al. Therapeutic comparison of a new budesonide/formoterol pMDI with budesonide pMDI and budesonide/ formoterol DPI in asthma. Int J Clin Pract. 2007;61:1874-1883.
24. Connolly DT, Heuvelman DM, Nelson R, et al. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. J Clin Invest. 1989;84:1470-1478.
25. Chetta A, Zanini A, Foresi A, et al. Vascular component of airway remodeling in asthma is reduced by dose of fluticasone. Am J Respir Crit Care Med. 2003;167:751-757.
26. Lee YC, Kwak YG, Song CH. Contribution of vascular endothelial growth factor to airway hyperresponsiveness and inflammation in a marine model of toluene diidocyanate-induced asthma. J Immunol. 2002;168:3595-3600.
27. Lee CG, Link H, Baluk P, et al. Vascular endothelial growth factor (VEGF) induces remodeling and enhances Th2-mediated sensitization and inflammation in the lung. Nat Med. 2004;10:1095-1103.
28. Yancopoulos GD, Davis S, Gale NW, Rudges JS, Wiegand SJ, Holash J. Vascular-specific growth factors and blood vessel formation. Nature. 2000;407:242-248.
29. Beck L Jr, D'Amore PA. Vascular development: Cellular and molecular regulation. FASEB J. 1997;11:365-373.
30. Lee KS, Min KH, Kim SR, et al. Vascular endothelial growth factor modulates matrix metalloproteinase-9 expression in asthma. Am J Respir Crit Care Med. 2006;174:161-170.
31. Vignola AM, Riccobono L, Mirabella A, et al. Sputum metalloproteinase-9 tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis. Am J Respir Crit Care Med. 1998;158:1925-1950.
32. Hoshino M, Takahashi M, Takai Y, Sim J. Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 expression in asthma. J Allergy Clin Immunol. 1999;104:356-363.
33. Okada S, Kita H, George TJ, Gleich GJ, Leiferman KM. Migration of eosinophils through basement membrane components in vitro: Role of matrix metalloproteinase-9. Am J Respir Cell Mol Biol. 1997;17:519-528.
34. Leppert D, Waubant E, Galardy R, Bunnett NW, Hauser SL. T cell gelatinases mediate basement membrane transmigaration in vitro. J Immunol. 1995;154:4379-4389.
35. Lee KS, Kim SR, Park HS, Jin GY, Lee YC. Cysteinyl leukotriene receptor antagonist regulates vascular permeability by reducing vascular endothelial growth factor expression. J Allergy Clin Immunol. 2004;114:1093-1099.
36. Lee YC, Lee HK. Vascular endothelial growth factor in patients with acute asthma. J Allergy Clin Immunol. 2001;107:1106.
37. Boulet LP, Laviolette M, Turcotte H, et al. Bronchial subepithelial fibrosis correlates with airway responsiveness to methacholine. Chest. 1997;112:45-52.
38. Beasley R, Roche WR, Roberts JA, Holgate ST. Cellular events in the bronchi in mild asthma and after bronchial provocation. Am Rev Respir Dis. 1989;139:806-817.
39. Chetta A, Foresi A, Del Donno M, Bertorelli G, Pesci A, Olivieri D. Airways remodeling is a distinctive feature of asthma and is related to severity of disease. Chest. 1997;111:852-857.
40. Leigh R, Pizzichini MM, Morris MM, et al. Stable COPD: Predicting benefit from high-dose inhaled corticosteroid treatment. Eur Respir J. 2006;27:964-971.