Measurement and impact of remodeling in the lung: Airway neovascularization in asthma

Proceedings of the American Thoracic Society

Volumn 6, Issue 8, 2009, Pages 673-677

  Bischof, Robert J ^a   Bourke, Jane E ^b   Hirst, Stuart J ^a   Meeusen, Els N T ^a   Snibson, Kenneth J ^b   Van Der Velden, Joanne ^b  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Airway smooth muscle; Airway vasculature; Angiogenesis; Bronchial circulation; Inflammation

Indexed keywords

ANGIOGENIN; CD31 ANTIGEN; ENDOSTATIN; FIBROBLAST GROWTH FACTOR 2; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; TOBACCO SMOKE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ADAM33 GENE; AIRWAY; ANGIOGENESIS; ASTHMA; BLOOD FLOW; BRONCHUS MUCOSA; DNA POLYMORPHISM; GENE; GENETIC SUSCEPTIBILITY; HUMAN; MICROCIRCULATION; NONHUMAN; PROTEIN EXPRESSION; RHINOVIRUS INFECTION; SHORT SURVEY; SMOOTH MUSCLE; TISSUE REPAIR;

AIRWAY REMODELING; ASTHMA; HUMANS; MUSCLE, SMOOTH; NEOVASCULARIZATION, PATHOLOGIC;

EID: 74849106649     PISSN: 15463222     EISSN: None     Source Type: Journal    
DOI: 10.1513/pats.200907-064DP     Document Type: Short Survey

References (58)

1. Bergeron C, Al-Ramli W, Hamid Q. Remodeling in asthma. Proc Am Thorac Soc 2009;6:301-305.
2. Dunnill MS. The pathology of asthma, with special reference to changes in the bronchial mucosa. J Clin Pathol 1960;13:27-33.
3. Tang ML, Wilson JW, Stewart AG, Royce SG. Airway remodelling in asthma: current understanding and implications for future therapies. Pharmacol Ther 2006;112:474-488.
4. Wilson JW, Bamford TL. Assessing the evidence for remodelling of the airway in asthma. Pulm Pharmacol Ther 2001;14:229-247.
5. Bai TR, Knight DA. Structural changes in the airways in asthma: observations and consequences. Clin Sci (Lond) 2005;108:463-477.
6. Wilson JW, Hii S. The importance of the airway microvasculature in asthma. Curr Opin Allergy Clin Immunol 2006;6:51-55.
7. Walters EH, Soltani A, Reid DW, Ward C. Vascular remodelling in asthma. Curr Opin Allergy Clin Immunol 2008;8:39-43.
8. Bailey SR, Boustany S, Burgess JK, Hirst SJ, Sharma HS, Simcock DE, Suravaram PR, Weckmann M. Airway vascular reactivity and vascularisation in human chronic airway disease. Pulm Pharmacol Ther 2009;22:417-425.
9. Paredi P, Barnes PJ. The airway vasculature: recent advances and clinical implications. Thorax 2009;64:444-450.
10. Chetta A, Zanini A, Olivieri D. Therapeutic approach to vascular remodelling in asthma. Pulm Pharmacol Ther 2007;20:1-8.
11. Zanini A, Chetta A, Olivieri D. Therapeutic perspectives in bronchial vascular remodeling in copd. Ther Adv Respir Dis 2008;2:179-187.
12. Dunnill MS, Massarella GR, Anderson JA. A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema. Thorax 1969;24:176-179.
13. Li X, Wilson JW. Increased vascularity of the bronchial mucosa in mild asthma. Am J Respir Crit Care Med 1997;156:229-233.
14. Chetta A, Zanini A, Torre O, Olivieri D. Vascular remodelling and angiogenesis in asthma: morphological aspects and pharmacological modulation. Inflamm Allergy Drug Targets 2007;6:41-45.
15. Hashimoto M, Tanaka H, Abe S. Quantitative analysis of bronchial wall vascularity in the medium and small airways of patients with asthma and COPD. Chest 2005;127:965-972.
16. Vrugt B, Wilson S, Bron A, Holgate ST, Djukanovic R, Aalbers R. Bronchial angiogenesis in severe glucocorticoid-dependent asthma. Eur Respir J 2000;15:1014-1021.
17. Salvato G. Quantitative and morphological analysis of the vascular bed in bronchial biopsy specimens from asthmatic and non-asthmatic subjects. Thorax 2001;56:902-906.
18. Tanaka H, Yamada G, Saikai T, Hashimoto M, Tanaka S, Suzuki K, Fujii M, Takahashi H, Abe S. Increased airway vascularity in newly diagnosed asthma using a high-magnification bronchovideoscope. Am J Respir Crit Care Med 2003;168:1495-1499.
19. Barbato A, Turato G, Baraldo S, Bazzan E, Calabrese F, Panizzolo C, Zanin ME, Zuin R, Maestrelli P, Fabbri LM, et al. Epithelial damage and angiogenesis in the airways of children with asthma. Am J Respir Crit Care Med 2006;174:975-981.
20. Koumoundouros E, Bischof RJ, Meeusen EN, Mareels IM, Snibson KJ. Chronic airway disease: deteriorating pulmonary function in sheep associated with repeated challenges of house dust mite. Exp Lung Res 2006;32:321-330.
21. Snibson KJ, Bischof RJ, Slocombe RF, Meeusen EN. Airway remodelling and inflammation in sheep lungs after chronic airway challenge with house dust mite. Clin Exp Allergy 2005;35:146-152.
22. Avdalovic MV, Putney LF, Schelegle ES, Miller L, Usachenko JL, Tyler NK, Plopper CG, Gershwin LJ, Hyde DM. Vascular remodeling is airway generation-specific in a primate model of chronic asthma. Am J Respir Crit Care Med 2006;174:1069-1076.
23. Horvath G, Vasas S, Wanner A. Inhaled corticosteroids reduce asthma-associated airway hyperperfusion through genomic and nongenomic mechanisms. Pulm Pharmacol Ther 2007;20:157-162.
24. Wiggs BR, Bosken C, Pare PD, James A, Hogg JC. A model of airway narrowing in asthma and in chronic obstructive pulmonary disease. Am Rev Respir Dis 1992;145:1251-1258.
25. Tuder RM, Yun JH. Vascular endothelial growth factor of the lung: friend or foe. Curr Opin Pharmacol 2008;8:255-260.
26. Feltis BN, Wignarajah D, Zheng L, Ward C, Reid D, Harding R, Walters EH. Increased vascular endothelial growth factor and receptors: relationship to angiogenesis in asthma. Am J Respir Crit Care Med 2006;173:1201-1207.
27. Asai K, Kanazawa H, Otani K, Shiraishi S, Hirata K, Yoshikawa J. Imbalance between vascular endothelial growth factor and endostatin levels in induced sputum from asthmatic subjects. J Allergy Clin Immunol 2002;110:571-575.
28. Hoshino M, Takahashi M, Aoike N. Expression of vascular endothelial growth factor, basic fibroblast growth factor, and angiogenin immuno-reactivity in asthmatic airways and its relationship to angiogenesis. J Allergy Clin Immunol 2001;107:295-301.
29. Simcock DE, Kanabar V, Clarke GW, O'Connor BJ, Lee TH, Hirst SJ. Proangiogenic activity in bronchoalveolar lavage fluid from patients with asthma. Am J Respir Crit Care Med 2007;176:146-153.
30. Redington AE, Roche WR, Madden J, Frew AJ, Djukanovic R, Holgate ST, Howarth PH. Basic fibroblast growth factor in asthma: measurement in bronchoalveolar lavage fluid basally and following allergen challenge. J Allergy Clin Immunol 2001;107:384-387.
31. Abdel-Rahman AM, el-Sahrigy SA, Bakr SI. A comparative study of two angiogenic factors: vascular endothelial growth factor and angiogenin in induced sputum from asthmatic children in acute attack. Chest 2006; 129:266-271.
32. Kristan SS, Malovrh MM, Silar M, Kern I, Flezar M, Kosnik M, Suskovic S, Korosec P. Airway angiogenesis in patients with rhinitis and controlled asthma. Clin Exp Allergy 2009;39:354-360.
33. Asai K, Kanazawa H, Kamoi H, Shiraishi S, Hirata K, Yoshikawa J. Increased levels of vascular endothelial growth factor in induced sputum in asthmatic patients. Clin Exp Allergy 2003;33:595-599.
34. Chetta A, Zanini A, Foresi A, D'Ippolito R, Tipa A, Castagnaro A, Baraldo S, Neri M, Saetta M, Olivieri D. Vascular endothelial growth factor up-regulation and bronchial wall remodelling in asthma. Clin Exp Allergy 2005;35:1437-1442.
35. Hoshino M, Nakamura Y, Hamid QA. Gene expression of vascular endothelial growth factor and its receptors and angiogenesis in bronchial asthma. J Allergy Clin Immunol 2001;107:1034-1038.
36. Lee YC, Lee HK. Vascular endothelial growth factor in patients with acute asthma. J Allergy Clin Immunol 2001;107:1106.
37. Simoes DC, Vassilakopoulos T, Toumpanakis D, Petrochilou K, Roussos C, Papapetropoulos A. Angiopoietin-1 protects against airway inflammation and hyperreactivity in asthma. Am J Respir Crit Care Med 2008;177:1314-1321.
38. Suzaki Y, Hamada K, Sho M, Ito T, Miyamoto K, Akashi S, Kashizuka H, Ikeda N, Nakajima Y, Iwase M, et al. A potent antiangiogenic factor, endostatin prevents the development of asthma in a murine model. J Allergy Clin Immunol 2005;116:1220-1227.
39. ten Brinke A. Risk factors associated with irreversible airflow limitation in asthma. Curr Opin Allergy Clin Immunol 2008;8:63-69.
40. Puxeddu I, Pang YY, Harvey A, Haitchi HM, Nicholas B, Yoshisue H, Ribatti D, Clough G, Powell RM, Murphy G, et al. The soluble form of a disintegrin and metalloprotease 33 promotes angiogenesis: Implications for airway remodeling in asthma. J Allergy Clin Immunol 2008;121:1400-1406.
41. Haitchi HM, Powell RM, Shaw TJ, Howarth PH, Wilson SJ, Wilson DI, Holgate ST, Davies DE. Adam33 expression in asthmatic airways and human embryonic lungs. Am J Respir Crit Care Med 2005;171:958-965.
42. Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, Torrey D, Pandit S, McKenny J, Braunschweiger K, et al. Association of the adam33 gene with asthma and bronchial hyperresponsiveness. Nature 2002;418:426-430.
43. St-Laurent J, Bergeron C, Page N, Couture C, Laviolette M, Boulet LP. Influence of smoking on airway inflammation and remodelling in asthma. Clin Exp Allergy 2008;38:1582-1589.
44. Rao SP, Sikora L, Hosseinkhani MR, Pinkerton KE, Sriramarao P. Exposure to environmental tobacco smoke induces angiogenesis and leukocyte trafficking in lung microvessels. Exp Lung Res 2009;35:119-135.
45. Amin K, Ekberg-Jansson A, Lofdahl CG, Venge P. Relationship between inflammatory cells and structural changes in the lungs of asymptomatic and never smokers: a biopsy study. Thorax 2003;58: 135-142.
46. Nissim Ben Efraim AH, Levi-Schaffer F. Tissue remodeling and angiogenesis in asthma: the role of the eosinophil. Ther Adv Respir Dis 2008;2:163-171.
47. Detoraki A, Staiano RI, Granata F, Giannattasio G, Prevete N, de Paulis A, Ribatti D, Genovese A, Triggiani M, Marone G. Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects. J Allergy Clin Immunol 2009;23:1142-1149.
48. Zanini A, Chetta A, Saetta M, Baraldo S, D'Ippolito R, Castagnaro A, Neri M, Olivieri D. Chymase-positive mast cells play a role in the vascular component of airway remodeling in asthma. J Allergy Clin Immunol 2007;120:329-333.
49. Puxeddu I, Alian A, Piliponsky AM, Ribatti D, Panet A, Levi-Schaffer F. Human peripheral blood eosinophils induce angiogenesis. Int J Biochem Cell Biol 2005;37:628-636.
50. Puxeddu I, Berkman N, Nissim Ben Efraim AH, Davies DE, Ribatti D, Gleich GJ, Levi-Schaffer F. The role of eosinophil major basic protein in angiogenesis. Allergy 2009;64:368-374.
51. Psarras S, Volonaki E, Skevaki CL, Xatzipsalti M, Bossios A, Pratsinis H, Tsigkos S, Gourgiotis D, Constantopoulos AG, Papapetropoulos A, et al. Vascular endothelial growth factor-mediated induction of angiogenesis by human rhinoviruses. J Allergy Clin Immunol 2006; 117:291-297.
52. De Silva D, Dagher H, Ghildyal R, Lindsay M, Li X, Freezer NJ, Wilson JW, Bardin PG. Vascular endothelial growth factor induction by rhinovirus infection. J Med Virol 2006;78:666-672.
53. Benayoun L, Druilhe A, Dombret MC, Aubier M, Pretolani M. Airway structural alterations selectively associated with severe asthma. Am J Respir Crit Care Med 2003;167:1360-1368.
54. Fehrenbach H, Kasper M, Haase M, Schuh D, Muller M. Differential immunolocalization of VEGF in rat and human adult lung, and in experimental rat lung fibrosis: light, fluorescence, and electron microscopy. Anat Rec 1999;254:61-73.
55. Kranenburg AR, de Boer WI, Alagappan VK, Sterk PJ, Sharma HS. Enhanced bronchial expression of vascular endothelial growth factor and receptors (flk-1 and flt-1) in patients with chronic obstructive pulmonary disease. Thorax 2005;60:106-113.
56. Simcock DE, Kanabar V, Clarke GW, Mahn K, Karner C, O'Connor BJ, Lee TH, Hirst SJ. Induction of angiogenesis by airway smooth muscle from patients with asthma. Am J Respir Crit Care Med 2008;178:460-468.
57. Trian T, Benard G, Begueret H, Rossignol R, Girodet PO, Ghosh D, Ousova O, Vernejoux JM, Marthan R, Tunon-de-Lara JM, et al. Bronchial smooth muscle remodeling involves calcium-dependent enhanced mitochondrial biogenesis in asthma. J Exp Med 2007;204: 3173-3181.
58. Hasaneen NA, Zucker S, Lin RZ, Vaday GG, Panettieri RA, Foda HD. Angiogenesis is induced by airway smooth muscle strain. Am J Physiol Lung Cell Mol Physiol 2007;293:L1059-L1068.