Quantitative study of focused ultrasound enhanced doxorubicin delivery to prostate tumor in vivo with MRI guidance

Medical Physics

Volumn 39, Issue 5, 2012, Pages 2780-2786

  Chen, Xiaoming ^a   Cvetkovic, Dusica ^a   Ma, C M ^a   Chen, Lili ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

doxorubicin; focused ultrasound; HIFU; prostate cancer

Indexed keywords

ANIMALS; BIOACOUSTICS; CALCIUM COMPOUNDS; CELL CULTURE; DISEASES; FLUORESCENCE IMAGING; INDIUM COMPOUNDS; PHANTOMS; TARGETED DRUG DELIVERY; TRACERS; TUMORS; ULTRASONICS; UROLOGY;

DOXORUBICIN; FOCUSED ULTRASOUND; HIFU; HISTOLOGICAL ANALYSIS; HUMAN PROSTATE CANCER; PARAMETRIC MEASUREMENTS; PROSTATE CANCERS; ULTRASOUND PARAMETERS;

CONTROLLED DRUG DELIVERY;

ANIMALIA;

EID: 84861629586     PISSN: 00942405     EISSN: None     Source Type: Journal    
DOI: 10.1118/1.4705346     Document Type: Article

References (29)

1. C. C. Coussios and R. A. Roy, Applications of acoustics and cavitation to noninvasive therapy and drug delivery., Annu. Rev. Fluid Mech. 40, 395-420 (2008). 10.1146/annurev.fluid.40.111406.102116 (Pubitemid 351234706)
2. J. E. Kennedy, High-intensity focused ultrasound in the treatment of solid tumours., Nat. Rev. Cancer 5, 321-327 (2005). 10.1038/nrc1591 (Pubitemid 40488637)
3. V. Frenkel, Ultrasound mediated delivery of drugs and genes to solid tumors., Adv. Drug Delivery Rev. 60, 1193-1208 (2008). 10.1016/j.addr.2008.03. 007
4. H. A. Hancock, L. H. Smith, J. Cuesta, A. K. Durrani, M. Angstadt, M. L. Palmeri, E. Kimmel, and V. Frenkel, Investigations into pulsed high-intensity focused ultrasound-enhanced delivery: Preliminary evidence for a novel mechanism., Ultrasound Med. Biol. 35, 1722-1736 (2009). 10.1016/j.ultrasmedbio. 2009.04.020
5. V. Frenkel, A. Etherington, M. Greene, J. Quijano, J. W. Xie, F. Hunter, S. Dromi, and K. C. P. Li, Delivery of liposomal doxorubicin (Doxil) in a breast cancer tumor model: Investigation of potential enhancement by pulsed-high intensity focused ultrasound exposure., Acad. Radiol. 13, 469-479 (2006). 10.1016/j.acra.2005.08.024
6. S. Dromi, V. Frenkel, A. Luk, B. Traughber, M. Angstadt, M. Bur, J. Poff, J. W. Xie, S. K. Libutti, K. C. P. Li, and B. J. Wood, Pulsed-high intensity focused ultrasound and low temperature sensitive liposomes for enhanced targeted drug delivery and antitumor effect., Clin. Cancer Res. 13, 2722-2727 (2007). 10.1158/1078-0432.CCR-06-2443 (Pubitemid 46788041)
7. E. L. Yuh, S. G. Shulman, S. A. Mehta, J. W. Xie, L. L. Chen, V. Frenkel, M. D. Bednarski, and K. C. P. Li, Delivery of systemic chemotherapeutic agent to tumors by using focused ultrasound: Study in a murine model., Radiology 234, 431-437 (2005). 10.1148/radiol.2342030889 (Pubitemid 40139913)
8. L. L. Chen, Z. M. Mu, P. Hachem, C. M. Ma, A. Wallentine, and A. Pollack, MR-guided focused ultrasound: Enhancement of intratumoral uptake of H-3-docetaxel in vivo., Phys. Med. Biol. 55, 7399-7410 (2010). 10.1088/0031-9155/55/24/001
9. K. Hynynen, N. McDannold, N. A. Sheikov, F. A. Jolesz, and N. Vykhodtseva, Local and reversible blood-brain barrier disruption by noninvasive focused ultrasound at frequencies suitable for trans-skull sonications., Neuroimage 24, 12-20 (2005). 10.1016/j.neuroimage.2004.06.046 (Pubitemid 39611021)
10. L. H. Treat, N. McDannold, N. Vykhodtseva, Y. Z. Zhang, K. Tam, and K. Hynynen, Targeted delivery of doxorubicin to the rat brain at therapeutic levels using MRI-guided focused ultrasound., Int. J. Cancer 121, 901-907 (2007). 10.1002/ijc.22732 (Pubitemid 47106223)
11. M. Gigli, S. M. Doglia, J. M. Millot, L. Valentini, and M. Manfait, Quantitative study of doxorubicin in living cell-nuclei by microspectrofluorometry., Biochim. Biophys. Acta 950, 13-20 (1988). 10.1016/0167-4781(88)90068-1
12. R. Petrioli, A. I. Fiaschi, E. Francini, A. Pascucci, and G. Francini, The role of doxorubicin and epirubicin in the treatment of patients with metastatic hormone-refractory prostate cancer., Cancer Treat Rev. 34, 710-718 (2008). 10.1016/j.ctrv.2008.05.004
13. A. Heidenreich, F. Sommer, C. H. Ohimann, A. J. Schrader, P. Olbert, J. Goecke, and U. H. Engelmann, Prospective randomized phase II trial of pegylated doxorubicin in the management of symptomatic hormone-refractory prostate carcinoma., Cancer 101, 948-956 (2004). 10.1002/cncr.20455 (Pubitemid 39100427)
14. K. A. Harris, E. Harney, and E. J. Small, Liposomal doxorubicin for the treatment of hormone-refractory prostate cancer., Clin. Prostate Cancer 1, 37-41 (2002). 10.3816/CGC.2002.n.005 (Pubitemid 37045885)
15. A. Das, D. Durrant, C. Mitchell, E. Mayton, N. N. Hoke, F. N. Salloum, M. A. Park, I. Qureshi, R. Lee, P. Dent, and R. C. Kukreja, Sildenafil increases chemotherapeutic efficacy of doxorubicin in prostate cancer and ameliorates cardiac dysfunction., Proc. Natl. Acad. Sci. U.S.A. 107, 18202-18207 (2010). 10.1073/pnas.1006965107
16. P. Singal, T. M. Li, D. Kumar, I. Danelisen, and N. Iliskovic, Adriamycin-induced heart failure: Mechanisms and modulation., Mol. Cell. Biochem. 207, 77-86 (2000). 10.1023/A:1007094214460
17. E. Rivera, Liposomal anthracyclines in metastatic breast cancer: Clinical update., Oncologist 8, 3-9 (2003). 10.1634/theoncologist.8-suppl-2-3 (Pubitemid 37152051)
18. F. Shen, S. Chu, A. K. Bence, B. Bailey, X. Xue, P. A. Erickson, M. H. Montrose, W. T. Beck, and L. C. Erickson, Quantitation of doxorubicin uptake, efflux, and modulation of multidrug resistance (MDR) in MDR human cancer cells., J. Pharmacol. Exp. Ther. 324, 95-102 (2008). 10.1124/jpet.107.127704 (Pubitemid 350294163)
19. A. Gabizon, R. Catane, B. Uziely, B. Kaufman, T. Safra, R. Cohen, F. Martin, A. Huang, and Y. Barenholz, Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes., Cancer Res. 54, 987-992 (1994). (Pubitemid 24085451)
20. Z. Mu, P. Hachem, H. Hensley, R. Stoyanova, H. W. Kwon, A. L. Hanlon, S. Agrawal, and A. Pollack, Antisense MDM2 enhances the response of androgen insensitive human prostate cancer cells to androgen deprivation in vitro and in vivo., Prostate 68, 599-609 (2008). 10.1002/pros.20731 (Pubitemid 351614638)
21. L. L. Chen, I. Rivens, G. Terhaar, S. Riddler, C. R. Hill, and J. P. M. Bensted, Histological-changes in rat-liver tumors treated with high-intensity focused ultrasound., Ultrasound Med. Biol. 19, 67-74 (1993). 10.1016/0301-5629(93)90019-K (Pubitemid 23088697)
22. K. Hynynen, Focused ultrasound for blood-brain disruption and delivery of therapeutic molecules into the brain., Expert Opin. Drug Deliv. 4, 27-35 (2007). 10.1517/17425247.4.1.27 (Pubitemid 46117484)
23. R. K. Jain, Delivery of molecular and cellular medicine to solid tumors., J. Controlled Release 53, 49-67 (1998). 10.1016/S0168-3659(97)00237-X (Pubitemid 28218689)
24. B. E. O'Neill, H. Vo, M. Angstadt, K. P. C. Li, T. Quinn, and V. Frenkel, Pulsed high intensity focused ultrasound mediated nanoparticle delivery: Mechanisms and efficacy in murine muscle., Ultrasound Med. Biol. 35, 416-424 (2009). 10.1016/j.ultrasmedbio.2008.09.021
25. K. M. Dittmar, J. W. Xie, F. Hunter, C. Trimble, M. Bur, V. Frenkel, and K. C. P. Li, Pulsed high-intensity focused ultrasound enhances systemic administration of naked DNA in squamous cell carcinoma model: Initial experience., Radiology 235, 541-546 (2005). 10.1148/radiol.2352040254 (Pubitemid 40571094)
26. A. Khaibullina, B. S. Jang, H. Sun, N. Lee, S. Yu, V. Frenkel, J. A. Carrasquillo, I. Pastan, K. C. P. Li, and C. H. Paik, Pulsed high-intensity focused ultrasound enhances uptake of radiolabeled monoclonal antibody to human epidermoid tumor in nude mice., J. Nucl. Med. 49, 295-302 (2008). 10.2967/jnumed.107.046888 (Pubitemid 351225669)
27. R. F. Greene, J. M. Collins, J. F. Jenkins, J. L. Speyer, and C. E. Myers, Plasma pharmacokinetics of adriamycin and adriamycinol-Implications for the design of invitro experiments and treatment protocols., Cancer Res. 43, 3417-3421 (1983). (Pubitemid 13061607)
28. K. M. Laginha, S. Verwoert, G. J. R. Charrois, and T. M. Allen, Determination of doxorubicin levels in whole tumor and tumor nuclei in murine breast cancer tumors., Clin. Cancer Res. 11, 6944-6949 (2005). 10.1158/1078-0432.CCR-05-0343 (Pubitemid 41428752)
29. C. M. Ma, D. Cvetkovic, X. Chen, and L. Chen, Non-thermal pulsed focused ultrasound for cancer therapy., Med. Phys. 38, 3824-3824 (2011). 10.1118/1.3613400