Delivery of liposomal doxorubicin (Doxil) in a breast cancer tumor model: Investigation of potential enhancement by pulsed-high intensity focused ultrasound exposure

Academic Radiology

Volumn 13, Issue 4, 2006, Pages 469-479

  Frenkel, Victor ^a   Etherington, Amena ^a   Greene, Maiya ^a   Quijano, Jade ^a   Xie, Jianwu ^a   Hunter, Finie ^a   Dromi, Sergio ^a   Li, King C P ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Acoustic radiation forces; Enhanced delivery; Liposomal doxorubicin; Pulsed high intensity focused ultrasound

Indexed keywords

DOXORUBICIN; FLUORESCENT DYE; LIPOSOME; POLYSTYRENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST ADENOCARCINOMA; BREAST CANCER; CONFOCAL LASER MICROSCOPY; CONTRAST ENHANCEMENT; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFECT; DRUG MUSCLE LEVEL; DRUG TUMOR LEVEL; DRUG UPTAKE; FEMALE; HISTOPATHOLOGY; LOW DRUG DOSE; MOUSE; NANOPARTICLE; NONHUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; SQUAMOUS CELL CARCINOMA; TEMPERATURE DEPENDENCE; TUMOR GROWTH; TUMOR REGRESSION; ULTRASOUND; VASODILATATION;

ADENOCARCINOMA; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DOXORUBICIN; DRUG DELIVERY SYSTEMS; FEMALE; LIPOSOMES; MAMMARY NEOPLASMS, EXPERIMENTAL; MICE; MICE, INBRED BALB C; SONICATION; TREATMENT OUTCOME;

EID: 33645084518     PISSN: 10766332     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.acra.2005.08.024     Document Type: Article

References (38)

1. R.M. Lowenthal, K. Eaton Toxicity of chemotherapy Hematol Oncol Clin N Am 10 1996 967 990
2. R.K. Jain Barriers to drug delivery in solid tumors Scient Am 271 1994 58 65
3. T.M. Allen Liposomes opportunities in drug delivery Drugs 54 Suppl 4 1997 8 14
4. F. Yuan, M. Leunig, S.K. Huang Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft Cancer Res 54 1994 3352 3356
5. A. Gabizon Pegylated liposomal doxorubicin metamorphosis of an old drug into a new form of chemotherapy Cancer Invest 19 2001 424 436
6. A. Gabizon, R. Catane, B. Uziely Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes Cancer Res 54 1994 987 992
7. G. Berry, M. Billingham, E. Alderman The use of cardiac biopsy to demonstrate reduced cardiotoxicity in AIDS Kaposi's sarcoma patients treated with pegylated liposomal doxorubicin Ann Oncol 9 1998 711 716
8. T. Tejada-Berges, C.O. Granai, M. Gordinier Caelyx/Doxil for the treatment of metastatic ovarian and breast cancer Exp Rev Anticancer Therapy 2 2002 143 150
9. M.R. Ranson, J. Carmichael, K. O'Byrne Treatment of advanced breast cancer with sterically stabilized liposomal doxorubicin results of a multicenter phase II trial J Clin Oncol 15 1997 3185 3191
10. M.R. Ranson, S. Cheeseman, S. White Caelyx (stealth liposomal doxorubicin) in the treatment of advanced breast cancer Crit Rev Oncol Hematol 37 2001 115 120
11. 2 Ann Oncol 11 2000 1029 1033
12. J.W. Snyder, W.R. Greco, D.A. Bellnier Photodynamic therapy a means to enhanced drug delivery to tumors Cancer Res 63 2003 8126 8131
13. G. Kong, R.D. Braun, M.W. Dewhirst Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature Cancer Res 61 2001 3021 3032
14. J. Wells, A. Sen, S.W. Hui Localized delivery to CT-26 tumors in mice using thermosensitive liposomes Int J Pharm 261 2003 105 114
15. A. Marin, H. Sun, G.A. Husseini Drug delivery in Pluronic micelles effect of high-frequency ultrasound on drug release from micelles and intracellular uptake J Control Release 84 2002 39 47
16. T. Uchida, N.T. Sanghvi, T.A. Gardner Transrectal high-intensity focused ultrasound for treatment of patients with stage T1b-2n0m0 localized prostate cancer a preliminary report Urology 59 2002 394 399
17. S. Thuroff, C. Chaussy, G. Vallancien High-intensity focused ultrasound and localized prostate cancer efficacy results from the European multicentric study J Endourol 17 2003 673 677
18. J.E. Kennedy, F. Wu, G.R. ter Haar High-intensity focused ultrasound for the treatment of liver tumours Ultrasonics 42 2004 931 935
19. F. Wu, Z.B. Wang, Y.D. Cao A randomised clinical trial of high-intensity focused ultrasound ablation for the treatment of patients with localised breast cancer Br J Cancer 89 2003 2227 2233
20. A.H. Chan, V.Y. Fujimoto, D.E. Moore An image-guided high intensity focused ultrasound device for uterine fibroids treatment Med Phys 29 2002 2611 2620
21. M.D. Bednarski, J.W. Lee, M.R. Callstrom In vivo target-specific delivery of macromolecular agents with MR-guided focused ultrasound Radiology 204 1997 263 268
22. E.L. Yuh, S.G. Shulman, S.A. Mehta Delivery of systemic chemotherapeutic agent to tumors by using focused ultrasound study in a murine model Radiology 234 2005 431 437
23. K.M. Dittmar, J. Xie, F. Hunter Pulsed high-intensity focused ultrasound enhances systemic administration of naked DNA in squamous cell carcinoma model initial experience Radiology 235 2005 541 546
24. Frenkel V, Oberoi J, Stone MJ, et al. Pulsed-high intensity ultrasound (HIFU) enhances thrombolysis in and in vitro model. Radiology. In press. Electronic version available at http://radiology.rsnajnls.org/cgi/content/ abstract/2391042181
25. Thomas P, Stone MJ, Durrani A, et al. Infrared imaging for monitoring pulsed-high intensity focused ultrasound (HIFU) induced temperature elevations in a tissue mimicking phantom. Proceedings of Inframation 2005, Las Vegas, NV.
26. T.R. Larson, D.G. Bostwick, A. Corica Temperature-correlated histopathologic changes following microwave thermoablation of obstructive tissue in patients with benign prostatic hyperplasia Urology 47 1996 463 469
27. S.K. Hobbs, W.L. Monsky, F. Yuan Regulation of transport pathways in tumor vessels role of tumor type and microenvironment Proc Natl Acad Sci U S A 95 1998 4607 4612
28. J.B. Kerr Atlas of functional histology 1999 Mosby London
29. T.M. Allen, F.J. Martin Advantages of liposomal delivery systems for anthracyclines Semin Oncol 31 2004 5 15
30. V. Frenkel, E. Kimmel, Y. Iger Ultrasound-induced intercellular space widening in fish epidermis Ultrasound Med Biol 26 2000 473 480
31. V. Frenkel, E. Kimmel, Y. Iger Ultrasound-facilitated transport of silver chloride (AgCl) particles in fish skin J Control Release 68 2000 251 261
32. H. Hashizume, P. Baluk, S. Morikawa Openings between defective endothelial cells explain tumor vessel leakiness Am J Pathol 156 2000 1363 1380
33. R.K. Jain Normalization of tumor vasculature an emerging concept in antiangiogenic therapy Science 307 2005 58 62
34. Y. Boucher, L.T. Baxter, R.K. Jain Interstitial pressure gradients in tissue-isolated and subcutaneous tumors implications for therapy Cancer Res 50 1990 4478 4484
35. P.A. Netti, D.A. Berk, M.A. Swartz Role of extracellular matrix assembly in interstitial transport in solid tumors Cancer Res 60 2000 2497 2503
36. C.P. Winlove, K.H. Parker The physiological function of the extracellular matrix R.K. Reed G.A. Laine J.L. Bert C.P. Winlove N. McHale Interstitium, connective tissue and lymphatics 1995 Portland Press London 137 165
37. R.A. Zlotecki, L.T. Baxter, Y. Boucher Pharmacologic modification of tumor blood flow and interstitial fluid pressure in a human tumor xenograft network analysis and mechanistic interpretation Microvasc Res 51 1996 400 442
38. J.R. Levick An introduction to cardiovascular physiology 2003 Oxford University Press New York