Linoleic acid activates GPR40/FFA1 and phospholipase C to increase [Ca 2+] i release and insulin secretion in islet beta-cells

Chinese Medical Sciences Journal

Volumn 27, Issue 1, 2012, Pages 18-23

  Zhou, Yi Jun ^a   Song, Yu Ling ^a   Zhou, Hui ^a   Li, Yan ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

antisense oligonucleotides; GPR40 FFA1; intracellular calcium; linoleic acid; phospholipase C

Indexed keywords

CALCIUM ION; G PROTEIN COUPLED RECEPTOR 40; INSULIN; LINOLEIC ACID; PHOSPHOLIPASE C;

ANIMAL CELL; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOFLUORESCENCE; INSULIN RELEASE; INTRACELLULAR SIGNALING; MALE; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; RAT; RECEPTOR DOWN REGULATION;

ANIMALS; CALCIUM; ENZYME ACTIVATION; INSULIN; INSULIN-SECRETING CELLS; LINOLEIC ACID; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; TYPE C PHOSPHOLIPASES;

EID: 84861620192     PISSN: 10019294     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1001-9294(12)60017-0     Document Type: Article

References (19)

1. M Cnop Fatty acids and glucolipotoxicity in the pathogenesis of type 2 diabetes Biochem Soc Trans 36 2008 348 352
2. JP Wilding The importance of free fatty acids in the development of type 2 diabetes Diabet Med 24 2007 934 945
3. P Steneberg, N Rubins, R Bartoov-Shifman et al. The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse Cell Metab 1 2005 245 258
4. A Salehi, E Flodgren, NE Nilsson et al. Free fatty acid receptor 1 (FFA(1) R/GPR40) and its involvement in fatty-acid-stimulated insulin secretion Cell Tissue Res 322 2005 207 215
5. Y Itoh, Y Kawamata, M Harada et al. Free fatty acids regulate insulin secretion from pancreatic beta cells through GPR40 Nature 422 2003 173 176
6. CP Briscoe, M Tadayyon, JL Andrews et al. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids J Biol Chem 278 2003 11303 11311
7. MG Latour, T Alquier, E Oseid et al. GPR40 is necessary but not sufficient for fatty acid stimulation of insulin secretion in vivo. Diabetes 56 2007 1087 1094
8. S Schnell, M Schaefer, C Schöfl Free fatty acids increase cytosolic free calcium and stimulate insulin secretion from β-cells through activation of GPR40 Mol Cell Endocrinol 263 2007 173 180
9. 2+ microdomains and the control of insulin secretion Cell Calcium 40 2006 539 551
10. 2+: new insights into stimulus-secretion coupling Diabetes 46 1997 1928 1938
11. + channel-independent insulinotropic action of glucose Diabetes 48 1999 1543 1549
12. S Del Guerra, M Bugliani, V D'Aleo et al. G-protein-coupled receptor 40 (GPR40) expression and its regulation in human pancreatic islets: the role of type 2 diabetes and fatty acids Nutr Metab Cardiovasc Dis 20 2010 22 25
13. 2+ handling Adv Exp Med Biol 513 2002 183 196
14. AR Hughes, JW Putney Jr Inositol phosphate formation and its relationship to calcium signaling Environ Health Perspect 84 1990 141 147
15. 2+ channel and link to insulin release Am J Physiol Endocrinol Metab 289 2005 E670 E677
16. H Shapiro, S Shachar, I Sekler et al. Role of GPR40 in fatty acid action on the beta cell line INS-1E Biochem Biophys Res Commun 335 2005 97 104
17. MJ Berridge Inositol trisphosphate and calcium signalling mechanisms Biochim Biophys Acta 1793 2009 933 940
18. S Katsuma, N Hatae, T Yano et al. Free fatty acids inhibit serum deprivation-induced apoptosis through GPR120 in a murine enteroendocrine cell line STC-1 J Biol Chem 280 2005 19507 19515
19. R Brownlie, RM Mayers, JA Pierce et al. The long-chain fatty acid receptor, GPR40, and glucolipotoxicity: investigations using GPR40-knockout mice Biochem Soc Trans 36 2008 950 954