ADP-ribosylation factor 6 expression and activation are reduced in myometrium in complicated pregnancies

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Kanamarlapudi, Venkateswarlu ^a   Owens, Sian E ^a   Lartey, Jon ^b,c   Bernal, Andrés ^b  

^a SWANSEA UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 1; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR 6; CYTOHESIN 1; CYTOHESIN 2; CYTOHESIN 3; CYTOHESIN 4; GUANINE NUCLEOTIDE EXCHANGE FACTOR; MESSENGER RNA; UNCLASSIFIED DRUG; ADENOSINE DIPHOSPHATE RIBOSYLATION FACTOR; ADP-RIBOSYLATION FACTOR 6; GUANOSINE TRIPHOSPHATE;

ARTICLE; CESAREAN SECTION; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MYOMETRIUM; NUCLEOTIDE SEQUENCE; PREGNANCY DISORDER; PREGNANT WOMAN; PREMATURE LABOR; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ENZYME ACTIVATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; PLACENTA; PREGNANCY; PREGNANCY COMPLICATION; TUMOR CELL LINE;

ADP-RIBOSYLATION FACTOR 1; ADP-RIBOSYLATION FACTORS; CELL LINE, TUMOR; ENZYME ACTIVATION; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANOSINE TRIPHOSPHATE; HUMANS; MYOMETRIUM; PLACENTA; PREGNANCY; PREGNANCY COMPLICATIONS; RNA, MESSENGER;

EID: 84861588164     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037954     Document Type: Article

References (46)

1. Creasy RK, (1991) Preventing preterm birth. N Engl J Med 325: 727-729.
2. Morrison JJ, Rennie JM, (1997) Clinical, scientific and ethical aspects of fetal and neonatal care at extremely preterm periods of gestation. Br J Obstet Gynaecol 104: 1341-1350.
3. Lartey J, Gampel A, Pawade J, Mellor H, Bernal AL, (2006) Expression of RND proteins in human myometrium. Biol Reprod 75: 452-461.
4. Ikebe M, Hartshorne DJ, Elzinga M, (1987) Phosphorylation of the 20,000-dalton light chain of smooth muscle myosin by the calcium-activated, phospholipid-dependent protein kinase. Phosphorylation sites and effects of phosphorylation. J Biol Chem 262: 9569-9573.
5. Somlyo AP, Somlyo AV, (2003) Ca2+ Sensitivity of Smooth Muscle and Nonmuscle Myosin II: Modulated by G Proteins, Kinases, and Myosin Phosphatase. Physiol Rev 83: 1325-1358.
6. Ito M, Nakano T, Erdodi F, Hartshorne DJ, (2004) Myosin phosphatase: structure, regulation and function. Mol Cell Biochem 259: 197-209.
7. Lopez Bernal A, (2007) The regulation of uterine relaxation. Semin Cell Dev Biol 18: 340-347.
8. Lartey J, Smith M, Pawade J, Strachan B, Mellor H, et al. (2007) Up-regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labor. Biol Reprod 76: 971-982.
9. Yuan W, Lopez Bernal A, (2007) Cyclic AMP signalling pathways in the regulation of uterine relaxation. BMC Pregnancy and Childbirth 2007 7: S10.
10. Gsandtner I, Charalambous C, Stefan E, Ogris E, Freissmuth M, et al. (2005) Heterotrimeric G protein-independent signaling of a G protein-coupled receptor. Direct binding of ARNO/cytohesin-2 to the carboxyl terminus of the A2A adenosine receptor is necessary for sustained activation of the ERK/MAP kinase pathway. J Biol Chem 280: 31898-31905.
11. Lopez Bernal A, (2003) Mechanisms of labour-biochemical aspects. BJOG 110 (Suppl 20): 39-45.
12. Uehata M, Ishizaki T, Satoh H, Ono T, Kawahara T, et al. (1997) Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389: 990-994.
13. Donaldson JG, Jackson CL, (2011) ARF family G proteins and their regulators: roles in membrane transport, development and disease. Nat Rev Mol Cell Biol 12: 362-375.
14. Mukherjee S, Gurevich VV, Jones JC, Casanova JE, Frank SR, et al. (2000) The ADP ribosylation factor nucleotide exchange factor ARNO promotes beta-arrestin release necessary for luteinizing hormone/choriogonadotropin receptor desensitization. Proc Natl Acad Sci U S A 97: 5901-5906.
15. Klarlund JK, Guilherme A, Holik JJ, Virbasius JV, Chawla A, et al. (1997) Signaling by phosphoinositide-3,4,5-trisphosphate through proteins containing pleckstrin and Sec7 homology domains. Science 275: 1927-1930.
16. Boshans RL, Szanto S, van Aelst L, D'Souza-Schorey C, (2000) ADP-ribosylation factor 6 regulates actin cytoskeleton remodeling in coordination with Rac1 and RhoA. Mol Cell Biol 20: 3685-3694.
17. Le Stunff H, Dokhac L, Bourgoin S, Bader MF, Harbon S, (2000) Phospholipase D in rat myometrium: occurrence of a membrane-bound ARF6 (ADP-ribosylation factor 6)-regulated activity controlled by betagamma subunits of heterotrimeric G-proteins. Biochem J 352 Pt 2: 491-499.
18. Giguere P, Rochdi MD, Laroche G, Dupre E, Whorton MR, et al. (2006) ARF6 activation by Galpha q signaling: Galpha q forms molecular complexes with ARNO and ARF6. Cell Signal 18: 1988-1994.
19. Madziva MT, Birnbaumer M, (2006) A role for ADP-ribosylation factor 6 in the processing of G-protein-coupled receptors. J Biol Chem 281: 12178-12186.
20. Lawrence J, Mundell SJ, Yun H, Kelly E, Venkateswarlu K, (2005) Centaurin-{alpha}1, an ADP-Ribosylation Factor 6 GTPase Activating Protein, Inhibits {beta}2-Adrenoceptor Internalization. Mol Pharmacol 67 1822-1828. Epub 2005 Mar 1818.
21. Mukherjee S, Casanova JE, Hunzicker-Dunn M, (2001) Desensitization of the luteinizing hormone/choriogonadotropin receptor in ovarian follicular membranes is inhibited by catalytically inactive ARNO(+). J Biol Chem 276: 6524-6528.
22. Venkateswarlu K, Brandom KG, Yun H, (2007) PI-3-kinase-dependent membrane recruitment of centaurin-alpha2 is essential for its effect on ARF6-mediated actin cytoskeleton reorganisation. J Cell Sci 120: 792-801.
23. Venkateswarlu K, (2003) Interaction protein for cytohesin exchange factors 1 (IPCEF1) binds cytohesin 2 and modifies its activity. J Biol Chem 278: 43460-43469.
24. Venkateswarlu K, Brandom KG, Lawrence JL, (2004) Centaurin-alpha1 is an in vivo phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein for ARF6 that is involved in actin cytoskeleton organization. J Biol Chem 279: 6205-6208.
25. Venkateswarlu K, (2005) Analysis of the interaction between cytohesin 2 and IPCEF1. Methods Enzymol 404: 252-266.
26. Venkateswarlu K, Gunn-Moore F, Oatey PB, Tavare JM, Cullen PJ, (1998) Nerve growth factor- and epidermal growth factor-stimulated translocation of the ADP-ribosylation factor-exchange factor GRP1 to the plasma membrane of PC12 cells requires activation of phosphatidylinositol 3-kinase and the GRP1 pleckstrin homology domain. Biochem J 335 (Pt 1): 139-146.
27. Venkateswarlu K, Cullen PJ, (2000) Signalling via ADP-ribosylation factor 6 lies downstream of phosphatidylinositide 3-kinase. Biochem J 345 Pt 3: 719-724.
28. Morishige M, Hashimoto S, Ogawa E, Toda Y, Kotani H, et al. (2008) GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion. Nat Cell Biol 10: 85-92.
29. Ridley AJ, Hall A, (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70: 389-399.
30. Cross MJ, Roberts S, Ridley AJ, Hodgkin MN, Stewart A, et al. (1996) Stimulation of actin stress fibre formation mediated by activation of phospholipase D. Curr Biol 6: 588-597.
31. Ha KS, Yeo EJ, Exton JH, (1994) Lysophosphatidic acid activation of phosphatidylcholine-hydrolysing phospholipase D and actin polymerization by a pertussis toxin-sensitive mechanism. Biochem J 303 (Pt 1): 55-59.
32. Hiroyama M, Exton JH, (2005) Localization and regulation of phospholipase D2 by ARF6. J Cell Biochem 95: 149-164.
33. Breuiller M, Rouot B, Litime MH, Leroy MJ, Ferre F, (1990) Functional coupling of the alpha 2-adrenergic receptor-adenylate cyclase complex in the pregnant human myometrium. J Clin Endocrinol Metab 70: 1299-1304.
34. Strakova Z, Soloff MS, (1997) Coupling of oxytocin receptor to G proteins in rat myometrium during labor: Gi receptor interaction. Am J Physiol 272: E870-876.
35. Daher Z, Noel J, Claing A, (2008) Endothelin-1 promotes migration of endothelial cells through the activation of ARF6 and the regulation of FAK activity. Cell Signal 20: 2256-2265.
36. Claing A, Chen W, Miller WE, Vitale N, Moss J, et al. (2001) beta-Arrestin-mediated ADP-ribosylation factor 6 activation and beta 2-adrenergic receptor endocytosis. J Biol Chem 276: 42509-42513. Epub 42001 Aug 42530.
37. Hunzicker-Dunn M, Gurevich VV, Casanova JE, Mukherjee S, (2002) ARF6: a newly appreciated player in G protein-coupled receptor desensitization. FEBS Lett 521: 3-8.
38. Kanamarlapudi V, Thompson A, Kelly E, Lopez Bernal A, (2012) ARF6 activated by the LHCG receptor through the cytohesin family of guanine nucleotide exchange factors mediates the receptor internalisation and signalling. J Biol Chem.
39. Jacobs S, Schilf C, Fliegert F, Koling S, Weber Y, et al. (1999) ADP-ribosylation factor (ARF)-like 4, 6, and 7 represent a subgroup of the ARF family characterization by rapid nucleotide exchange and a nuclear localization signal. FEBS Lett 456: 384-388.
40. Li CC, Chiang TC, Wu TS, Pacheco-Rodriguez G, Moss J, et al. (2007) ARL4D recruits cytohesin-2/ARNO to modulate actin remodeling. Mol Biol Cell 18: 4420-4437.
41. Miko E, Szereday L, Barakonyi A, Jarkovich A, Varga P, et al. (2009) Immunoactivation in preeclampsia: Vdelta2+ and regulatory T cells during the inflammatory stage of disease. J Reprod Immunol 80: 100-108.
42. Nonaka Y, Tsuda N, Shichijo S, Ito M, Maeda Y, et al. (2002) Recognition of ADP-ribosylation factor 4-like by HLA-A2-restricted and tumor-reactive cytotoxic T lymphocytes from patients with brain tumors. Tissue Antigens 60: 319-327.
43. Yuan W, Duffner AM, Chen L, Hunt LP, Sellers SM,et al. Analysis of preterm deliveries below 35 weeks' gestation in a tertiary referral hospital in the UK. A case-control survey. BMC Res Notes 3: 119.
44. Newton DA, Rao KM, Dluhy RA, Baatz JE, (2006) Hemoglobin is expressed by alveolar epithelial cells. J Biol Chem 281: 5668-5676.
45. Hashimoto S, Onodera Y, Hashimoto A, Tanaka M, Hamaguchi M, et al. (2004) Requirement for Arf6 in breast cancer invasive activities. Proc Natl Acad Sci U S A 101: 6647-6652.
46. Lee YN, Park YG, Choi YH, Cho YS, Cho-Chung YS, (2000) CRE-transcription factor decoy oligonucleotide inhibition of MCF-7 breast cancer cells: cross-talk with p53 signaling pathway. Biochemistry 39: 4863-4868.