Immunoactivation in preeclampsia: Vδ2+ and regulatory T cells during the inflammatory stage of disease

Journal of Reproductive Immunology

Volumn 80, Issue 1-2, 2009, Pages 100-108

  Miko, Eva ^a   Szereday, Laszlo ^a   Barakonyi, Aliz ^a   Jarkovich, Andrea ^a   Varga, Peter ^a   Szekeres Bartho, Julia ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

Author keywords

NK cell receptors; Preeclampsia; Regulatory T cells; TIM 3; V 2+ T cells

Indexed keywords

CD69 ANTIGEN; FAS ANTIGEN; GAMMA INTERFERON; NATURAL KILLER CELL RECEPTOR; NATURAL KILLER CELL RECEPTOR NKG2A; NATURAL KILLER CELL RECEPTOR NKG2C; PERFORIN; TISSUE INHIBITOR OF METALLOPROTEINASE 3; UNCLASSIFIED DRUG; HAVCR2 PROTEIN, HUMAN; KLRC2 PROTEIN, HUMAN; LYMPHOCYTE ANTIGEN RECEPTOR; MEMBRANE PROTEIN; NATURAL KILLER CELL LECTIN LIKE RECEPTOR SUBFAMILY C; T CELL RECEPTOR VDELTA2, HUMAN; T-CELL RECEPTOR VDELTA2, HUMAN;

ADULT; APOPTOSIS; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HUMAN; HUMAN CELL; LYMPHOCYTE FUNCTION; PATHOGENESIS; PHENOTYPE; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; TH1 CELL; V DELTA 2 T LYMPHOCYTE; DISEASE COURSE; GENE EXPRESSION REGULATION; GENETICS; IMMUNOLOGY; IMMUNOPHENOTYPING; INFLAMMATION; LYMPHOCYTE ACTIVATION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PREGNANCY; SECRETION; T LYMPHOCYTE SUBPOPULATION;

ADULT; ANTIGENS, CD95; APOPTOSIS; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; IMMUNOPHENOTYPING; INFLAMMATION; INTERFERON-GAMMA; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; NK CELL LECTIN-LIKE RECEPTOR SUBFAMILY C; PERFORIN; PRE-ECLAMPSIA; PREGNANCY; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 67349168755     PISSN: 01650378     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jri.2009.01.003     Document Type: Article

References (30)

1. Adams E.J., Chien Y.-H., and Garcia K.C. Structure of a gammadelta T cell receptor in complex with the nonclassical MHC T22. Science 308 (2005) 227-231
2. Aluvihare V.R., Kallikourdis N., and Betz A.G. Regulatory T cells mediate maternal tolerance to the fetus. Nat. Immunol. 5 (2004) 266-271
3. Anderson A.C., Anderson D.E., Bregoli L., Hastings W.D., Kassam N., Lei C., Chandwaskar R., Karman J., Su E.W., Hirashima M., Bruce J.N., Kane L.P., Kuchroo V.K., and Hafler D.A. Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells. Science 318 (2007) 1141-1143
4. Baecher-Allan C., Brown J.A., Gordon J., Freeman G.J., and Hafler D.A. CD4+CD25high regulatory cells human peripheral blood. J. Immunol. 167 (2001) 1245-1253
5. Barakonyi A., Polgar B., and Szekeres-Bartho J. The role of γ/δ T-cell positive cells in pregnancy: Part II. Am. J. Reprod. Immunol. 42 (1999) 83-87
6. Beetz S., Wesch D., Marischen L., Welte S., Oberg H.H., and Kabelitz D. Innate immune functions of human gammadelta T cells. Immunobiology 213 (2008) 173-182
7. Borzychowski A.M., Croy B.A., Chan W.L., Redman C.W., and Sargent I.L. Changes in systemic type 1 and type 2 immunity in normal pregnancy and preeclampsia may be mediated by natural killer cells. Eur. J. Immunol. 10 (2005) 3054-3063
8. Borzychowski A.M., Sargent I.L., and Redman C.W.G. Inflammation and pre-eclampsia. Seminars in Fetal & Neonatal Medicine 11 (2006) 309-316
9. Brandes M., Willimann K., Lang A.B., Nam K.H., Jin C., Brenner M.B., Morita C.T., and Moser B. Flexible migration program regulates gamma delta T-cell involvement in humoral immunity. Blood 102 (2003) 3693-3701
10. Carding S.R., and Egan P.J. Gammadelta T cells: functional plasticity and heterogeneity. Nat. Rev. Immunol. 2 (2002) 336-345
11. Darmochwal-Kolarz D., Leszczynska-Gorzelak B., Rolinski J., and Oleszczuk J. T helper 1- and T helper 2-type cytokine imbalance in pregnant women with pre-eclampsia. Eur. J. Obstet. Gynecol. Reprod. Biol. 86 (1999) 165-170
12. Eberl M., Hintz M., Reichenberg A., Kollas A.K., Wiesner J., and Jomaa H. Microbial isoprenoid biosynthesis and human gammadelta T cell activation. FEBS Lett. 544 (2003) 4-10
13. Graca L., Thompson S., Lin C.Y., Adams E., Cobbold S.P., and Waldmann H. Both CD4+CD25+ and CD4+CD25- regulatory cells mediate dominant transplantation tolerance. J. Immunol. 168 (2002) 5558-5565
14. Jiang S.P., and Vaccio M.S. Multiple mechanisms of peripheral T cell tolerance to the fetal 'allograft'. J. Immunol. 160 (1998) 3086-3090
15. Kingsley C.I., Karim M., Bushell A.R., and Wood K.J. CD25+CD4+ regulatory T cells prevent graft rejection: CTLA-4- and IL-10-dependent immunoregulation of alloresponses. J. Immunol. 168 (2002) 1080-1086
16. Leslie D.S., Vincent M.S., Spada F.M., Das H., Sugita M., Morita C.T., and Brenner M.B. CD1-mediated gamma/delta T cell maturation of dendritic cells. J. Exp. Med. 196 (2002) 1575-1584
17. Monney L., Sabatos C.A., Gaglia J.L., Ryu A., Waldner H., Chernova T., Manning S., Greenfield E.A., Coyle A.J., Sobel R.A., Freeman G.J., and Kuchroo V.K. Th1-specific cell surface protein TIM-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415 (2002) 536-541
18. Redman C.W., Sacks G.P., and Sargent I.L. Preeclampsia: an excessive maternal inflammatory response to pregnancy. Am. J. Obstet. Gynecol. 180 (1999) 499-506
19. Riley J.K., and Yokoyama W.M. NK cell tolerance and the maternal-fetal interface. Am. J. Reprod. Immunol. 59 (2008) 371-387
20. Sabatos C.A., Chakravarti S., Cha E., Schubart A., Sánchez-Fueyo A., Zheng X.X., Coyle A.J., Strom T.B., Freeman G.J., and Kuchroo V.K. Interaction of TIM-3 and TIM-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat. Immunol. 4 (2003) 1102-1110
21. Saito S., Sakai M., Sasaki Y., Nakashima A., and Shiozaki A. Inadequate tolerance induction may induce pre-eclampsia. J. Reprod. Immunol. 76 (2007) 30-39
22. Sancho-Fueyo A., Tian J., Picarella D., Domenig C., Zheng X.X., Sabatos C.A., Manlongat N., Bender O., Kamradt T., Kuchroo V.K., Gutiérrez-Ramos J.C., Coyle A.J., and Strom T.B. Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance. Nat. Immunol. 4 (2003) 1093-1101
23. Nagahara K., Arikawa T., Oomizu S., Kontani K., Nobumoto A., Tateno H., Watanabe K., Niki T., Katoh S., Miyake M., Nagahata S., Hirabayashi J., Kuchroo V.K., Yamauchi A., and Hirashima M. Galectin-9 increases Tim-3+ dendritic cells and CD8+ T cells and enhances antitumor immunity via galectin-9-Tim-3 interactions. J. Immunol. 181 (2008) 7660-7669
24. Sasaki Y., Sakai M., Miyazaki S., Higuma S., Shiozaki A., and Saito S. Decidual and peripheral blood CD4+CD25+ regulatory T cells in early pregnancy subjects and spontaneous abortion cases. Mol. Hum. Reprod. 10 (2004) 347-353
25. Sasaki Y., Darmochwal-Kolarz D., Suzuki D., Sakai M., Ito M., Shima T., Shiozaki A., Rolinski J., and Saito S. Proportion of peripheral blood and decidual CD4(+) CD25(bright) regulatory T cells in pre-eclampsia. Clin. Exp. Immunol. 149 (2007) 139-145
26. Scotet E., Nedellec S., Devilder M.C., Allain S., and Bonneville M. Bridging innate and adaptive immunity through gammadelta T-dendritic cell crosstalk. Front Biosci. 13 (2008) 6872-6885
27. Steinborn A., Haensch G.M., Mahnke K., Schmitt E., Toermer A., Meuer S., and Sohn C. Distinct subsets of regulatory T cells during pregnancy: is the imbalance of these subsets involved in the pathogenesis of preeclampsia?. Cell. Immunol. 129 (2008) 401-412
28. Toldi G., Svec P., Vasarhelyi B., Meszaros G., Rigo J., Tulassay T., and Treszl A. Decreased number of FoxP3+ regulatory T cells in preeclampsia. Acta Obstet. Gynecol. 87 (2008) 1229-1233
29. Vincent M.S., Leslie D.S., Gumperz J.E., Xiong X., Grant E.P., and Brenner M.B. CD1-dependent dendritic cell instruction. Nat. Immunol. 3 (2002) 1163-1168
30. Wang F., He W., Zhou H., Yuan J., Wu K., Xu L., and Chen Z.K. The Tim-3 ligand galectin-9 negatively regulates CD8+ alloreactive T cell and prolongs survival of skin graft. Cell. Immunol. 250 (2007) 68-74