Discovery, design and synthesis of Y-shaped peroxisome proliferator- activated receptor δ agonists as potent anti-obesity agents in vivo

European Journal of Medicinal Chemistry

Volumn 53, Issue , 2012, Pages 190-202

  Ham, Jungyeob ^a   Hwang, Hoosang ^a   Kim, Euno ^a   Kim, Jeong Ah ^a   Cho, Sung Jin ^a   Ko, Jaeyoung ^a   Lee, Woojin ^a   Lee, Jaehwan ^a   Holla, Harish ^a   Banerjee, Joydeep ^a   Kim, Seokho ^a   Yang, Inho ^a   Lee, Hyun Joo ^a   Shin, Kyoungjin ^a   Choi, Hyukjae ^a   Nam, Sang Jip ^b   Tak, Jungae ^a   Hahn, Dongyup ^a   Oh, Taekyung ^a   Won, Dong Hwan ^a   Lee, Tae Gu ^a   Choi, Jihye ^a   Park, Mi Sun ^a   Seok, Chaok ^a   Chin, Jungwook ^a   Kang, Heonjoong ^a   more..

^a Seoul National University   (South Korea)

^b Sunchon National University   (South Korea)

Author keywords

Anti obesity; GW501516; Marine natural products; Nuclear receptors; PPAR

Indexed keywords

2 [2 METHYL 4 [1 [4 METHYL 2 [1 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL] 3 PHENYLPROPYLTHIO]PHENOXY]ACETIC ACID; 2 [2 METHYL 4 [1 [4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL] 11 PHENYLUNDECYLTHIO]PHENOXY]ACETIC ACID; 2 [2 METHYL 4 [1 [4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL] 2 [4 (TRIFLUOROMETHYL)PHENYL]ETHYLTHIO]PHENOXY]ACETIC ACID; 2 [2 METHYL 4 [1 [4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL] 2 PHENYLETHYLTHIO]PHENOXY]ACETIC ACID; 2 [2 METHYL 4 [1 [4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL] 4 PHENYLBUTYLTHIO]PHENOXY]ACETIC ACID; 2 [2 METHYL 4 [1 [4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL] 5 PHENYLPENTYLTHIO]PHENOXY]ACETIC ACID; 2 [2 METHYL 4 [1 [4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL] 5-YL] 2 (4 NITROPHENYL)ETHYLTHIO]PHENOXY]ACETIC ACID; 2 [2 METHYL 4 [1 [4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL] 6 PHENYLHEXYLTHIO]PHENOXY]ACETIC ACID; 2 [2 METHYL 4 [1 [4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL] 8 PHENYLOCTYLTHIO]PHENOXY]ACETIC ACID; 2 [2 METHYL 4 [1 [4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL]ETHYLTHIO]PHENOXY]ACETIC ACID; 2 [2 METHYL 4 [1 [4 METHYL 2 [4( TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL] 2 PHENYLETHYLTHIO]PHENOXY]ACETIC ACID; 2 [4 ([2 (ANTHRACEN 9 YL) 1 [4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL]ETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; 2 [4 [2 (2 CHLORO 6 FLUOROPHENYL) 1 [4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL]ETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; 2 [4 [2 (2,4 DICHLOROPHENYL) 1 [4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL]ETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; 2 [4 [2 (2,5 DICHLOROPHENYL) 1 [4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL]ETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; 2 [4 [2 (2,6 DICHLOROPHENYL) 1 [4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL]ETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; 2 [4 [2 (2,6 DIFLUOROPHENYL) 1 (4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL]ETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; 2 [4 [2 (2,6 DIFLUOROPHENYL) 1 [4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL]ETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; 2 [4 [2 (4 METHOXYPHENYL) 1 [4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL]ETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; 2 [4 [2 [2 FLUORO 6 (TRIFLUOROMETHYL)PHENYL] 1 [4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL]ETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; 2 METHYL 4 [[4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL]METHYLTHIO]PHENOL; 5 [1 [4 (TERT BUTYLDIMETHYLSILYLOXY) 3 METHYLPHENYLTHIO] 2 PHENYLETHYL] 4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOLE; 5 [[4 (TERT BUTYLDIMETHYLSILYLOXY) 3 METHYLPHENYLTHIO]METHYL] 4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOLE; ANTIOBESITY AGENT; ETHYL 2 [2 METHYL 4 [1 [4 METHYL 2 [4 (TRIFLUOROMETHYL)PHENYL]THIAZOL 5 YL] 2 PHENYLETHYLTHIO]PHENOXY]ACETATE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VIVO STUDY; MOUSE; NONHUMAN; OBESITY;

ANIMALS; ANTI-OBESITY AGENTS; CHEMISTRY TECHNIQUES, SYNTHETIC; DIET, HIGH-FAT; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; HUMANS; MICE; MODELS, MOLECULAR; OBESITY; PPAR DELTA; PROTEIN CONFORMATION;

EID: 84861584756     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.03.055     Document Type: Article

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