A stereo-controlled synthesis of 2,4-dimethyl-4-hydroxy-16- phenylhexadecanoic acid 1,4-lactone and its PPAR activities

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 20, 2010, Pages 6017-6019

  Ko, Jaeyoung ^a   Hwang, Hoosang ^a   Chin, Jungwook ^a   Hahn, Dongyup ^a   Lee, Jaehwan ^a   Yang, Inho ^a   Shin, Kyoungjin ^a   Ham, Jungyeob ^b   Kang, Heonjoong ^a  

^a Seoul National University   (South Korea)

^b Korea Institute of Science and Technology   (South Korea)

Author keywords

Marine agonist; Nuclear receptor; PPAR dual agonist

Indexed keywords

2,4 DIMETHYL 4 HYDROXY 16 PHENYLHEXADECANOIC ACID 1,4 LACTONE; GAMMA LACTONE DERIVATIVE; KETONE; METHACRYLIC ACID; NATURAL PRODUCT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DOSE RESPONSE; ENZYME ACTIVITY; STEREOCHEMISTRY; SYNTHESIS;

ANIMALS; CELL LINE; LACTONES; MOLECULAR STRUCTURE; PALMITIC ACID; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; PLAKORTIS; PPAR ALPHA; PPAR GAMMA; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956933869     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.08.069     Document Type: Article

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