Racial disparities and sex-based outcomes differences after severe injury

Journal of the American College of Surgeons

Volumn 214, Issue 6, 2012, Pages 973-980

  Sperry, Jason L ^a   Vodovotz, Yoram ^a   Ferrell, Robert E ^a   Namas, Rami ^a   Chai, Yi Min ^b   Feng, Qi Ming ^b   Jia, Wei Ping ^b   Forsythe, Raquel M ^a   Peitzman, Andrew B ^a   Billiar, Timothy R ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BLUNT TRAUMA; FEMALE; HUMAN; INJURY SEVERITY; MAJOR CLINICAL STUDY; MALE; MORTALITY; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RACE DIFFERENCE; SCORING SYSTEM; SEX DIFFERENCE; SURVIVAL RATE; X CHROMOSOME LINKAGE;

ADULT; AGED; CONFIDENCE INTERVALS; CONTINENTAL POPULATION GROUPS; FEMALE; HEALTH STATUS DISPARITIES; HEALTHCARE DISPARITIES; HUMANS; MALE; MIDDLE AGED; ODDS RATIO; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; SEX DISTRIBUTION; SEX FACTORS; TRAUMA SEVERITY INDICES; UNITED STATES; WOUNDS AND INJURIES;

EID: 84861577302     PISSN: 10727515     EISSN: 18791190     Source Type: Journal    
DOI: 10.1016/j.jamcollsurg.2012.02.020     Document Type: Article

References (51)

1. M.A. Choudhry, K.I. Bland, I.H. Chaudry Gender and susceptibility to sepsis following trauma Endocr Metab Immune Disord Drug Targets 6 2006 127 135 (Pubitemid 43884172)
2. J.L. Sperry, J.P. Minei Gender dimorphism following injury: making the connection from bench to bedside J Leukoc Biol 83 2008 499 506 (Pubitemid 351966857)
3. M.K. Angele, M.W. Knoferl, A. Ayala Testosterone and estrogen differently effect Th1 and Th2 cytokine release following trauma-haemorrhage Cytokine 16 2001 22 30 (Pubitemid 34925822)
4. M.K. Angele, M.G. Schwacha, A. Ayala, I.H. Chaudry Effect of gender and sex hormones on immune responses following shock Shock 14 2000 81 90
5. M.K. Angele, A. Ayala, W.G. Cioffi Testosterone: the culprit for producing splenocyte immune depression after trauma hemorrhage Am J Physiol 274 1998 C1530 C1536
6. M.K. Angele, A. Ayala, B.A. Monfils Testosterone and/or low estradiol: normally required but harmful immunologically for males after trauma-hemorrhage J Trauma 44 1998 78 85 (Pubitemid 28095823)
7. D. Jarrar, P. Wang, W.G. Cioffi The female reproductive cycle is an important variable in the response to trauma-hemorrhage Am J Physiol Heart Circ Physiol 279 2000 H1015 H1021
8. M.W. Knoferl, D. Jarrar, M.K. Angele 17 beta-Estradiol normalizes immune responses in ovariectomized females after trauma-hemorrhage Am J Physiol Cell Physiol 281 2001 C1131 C1138
9. M.A. Choudhry, M.G. Schwacha, W.J. Hubbard Gender differences in acute response to trauma-hemorrhage Shock 24 2005 101 106
10. S. Yang, S. Hu, J. Chen Mechanism of hepatoprotection in proestrus female rats following trauma-hemorrhage: heme oxygenase-1-derived normalization of hepatic inflammatory responses J Leukocyte Biol 85 2009 1015 1026
11. L.A. Dossett, B.R. Swenson, D. Heffernan High levels of endogenous estrogens are associated with death in the critically injured adult J Trauma 64 2008 580 585 (Pubitemid 351366872)
12. L.A. Dossett, B.R. Swenson, H.L. Evans Serum estradiol concentration as a predictor of death in critically ill and injured adults Surgical Infect (Larchmt) 9 2008 41 48 (Pubitemid 351440539)
13. A.K. May, L.A. Dossett, P.R. Norris Estradiol is associated with mortality in critically ill trauma and surgical patients Crit Care Med 36 2008 62 68
14. C.D. Wohltmann, G.A. Franklin, P.W. Boaz A multicenter evaluation of whether gender dimorphism affects survival after trauma Am J Surg 181 2001 297 300 (Pubitemid 32595674)
15. B.J. Bowles, B. Roth, D. Demetriades Sexual dimorphism in trauma? A retrospective evaluation of outcome Injury 34 2003 27 31 (Pubitemid 36071402)
16. M.A. Croce, T.C. Fabian, A.K. Malhotra Does gender difference influence outcome? J Trauma 53 2002 889 894 (Pubitemid 35334783)
17. A. Oberholzer, M. Keel, R. Zellweger Incidence of septic complications and multiple organ failure in severely injured patients is sex specific J Trauma 48 2000 932 937 (Pubitemid 30435962)
18. J.F. Rappold, R. Coimbra, D.B. Hoyt Female gender does not protect blunt trauma patients from complications and mortality J Trauma 53 2002 436 441 discussion 441
19. R. Coimbra, D.B. Hoyt, B.M. Potenza Does sexual dimorphism influence outcome of traumatic brain injury patients? The answer is no! J Trauma 54 2003 689 700 (Pubitemid 36538222)
20. P.J. Offner, E.E. Moore, W.L. Biffl Male gender is a risk factor for major infections after surgery Arch Surg 134 1999 935 938 discussion 938-940
21. R.L. George, G. McGwin Jr, J. Metzger The association between gender and mortality among trauma patients as modified by age J Trauma 54 2003 464 471 (Pubitemid 36383742)
22. R.L. George, G. McGwin Jr, S.T. Windham Age-related gender differential in outcome after blunt or penetrating trauma Shock 19 2003 28 32
23. J.L. Sperry, A.B. Nathens, H.L. Frankel Characterization of the gender dimorphism after injury and hemorrhagic shock: are hormonal differences responsible? Crit Care Med 36 2008 1838 1845
24. B.R. Migeon Why females are mosaics, X-chromosome inactivation, and sex differences in disease Gend Med 4 2007 97 105 (Pubitemid 47245012)
25. B.R. Migeon The role of X inactivation and cellular mosaicism in women's health and sex-specific diseases JAMA 295 2006 1428 1433
26. C. Gunter Genome biology: she moves in mysterious ways Nature 434 2005 279 280 (Pubitemid 40469150)
27. B.R. Migeon X-chromosome inactivation: molecular mechanisms and genetic consequences Trends Genet 10 1994 230 235 (Pubitemid 24207944)
28. B.R. Migeon X chromosome inactivation: theme and variations Cytogenetic Genome Res 99 2002 8 16 (Pubitemid 37467818)
29. B.R. Migeon X inactivation, female mosaicism, and sex differences in renal diseases J Am Soc Nephrol 19 2008 2052 2059
30. G. Liu, Y. Tsuruta, Z. Gao Variant IL-1 receptor-associated kinase-1 mediates increased NF-kappa B activity J Immunol 179 2007 4125 4134
31. J. Arcaroli, E. Silva, J.P. Maloney Variant IRAK-1 haplotype is associated with increased nuclear factor-kappaB activation and worse outcomes in sepsis Am J Respir Crit Care Med 173 2006 1335 1341 (Pubitemid 43900707)
32. J. Toubiana, E. Courtine, F. Pene IRAK1 functional genetic variant affects severity of septic shock Crit Care Med 38 2010 2287 2294
33. R. Ishida, M. Emi, Y. Ezura Association of a haplotype (196Phe/532Ser) in the interleukin-1-receptor-associated kinase (IRAK1) gene with low radial bone mineral density in two independent populations J Bone Miner Res 18 2003 419 423 (Pubitemid 36241057)
34. J.L. Sperry, R.S. Friese, H.L. Frankel Male gender is associated with excessive IL-6 expression following severe injury J Trauma 64 2008 572 578 discussion 578-579 (Pubitemid 351366870)
35. L. Manship, R.D. McMillin, J.J. Brown The influence of sepsis and multisystem and organ failure on mortality in the surgical intensive care unit Am Surg 50 1984 94 101 (Pubitemid 14182578)
36. A. Sauaia, F.A. Moore, E.E. Moore Epidemiology of trauma deaths: a reassessment J Trauma 38 1995 185 193
37. A.E. Baue, R. Durham, E. Faist Systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF): are we winning the battle? Shock 10 1998 79 89 (Pubitemid 128463838)
38. A.B. Nathens, J.C. Marshall Sepsis, SIRS, and MODS: what's in a name? World J Surg 20 1996 386 391
39. C.J. Carrico, J.L. Meakins, J.C. Marshall Multiple-organ-failure syndrome Arch Surg 121 1986 196 208
40. R.M. Roumen, H. Redl, G. Schlag Inflammatory mediators in relation to the development of multiple organ failure in patients after severe blunt trauma Crit Care Med 23 1995 474 480
41. Y. Mizushima, P. Wang, D. Jarrar Estradiol administration after trauma-hemorrhage improves cardiovascular and hepatocellular functions in male animals Ann Surg 232 2000 673 679
42. D.E. Remmers, P. Wang, W.G. Cioffi Testosterone receptor blockade after trauma-hemorrhage improves cardiac and hepatic functions in males Am J Physiol 273 1997 H2919 H2925
43. D.J. Kaczorowski, K.P. Mollen, R. Edmonds, T.R. Billiar Early events in the recognition of danger signals after tissue injury J Leukocyte Biol 83 2008 546 552 (Pubitemid 351966863)
44. D.J. Kaczorowski, A. Nakao, K.P. Mollen Toll-like receptor 4 mediates the early inflammatory response after cold ischemia/reperfusion Transplantation 84 2007 1279 1287 (Pubitemid 351339316)
45. R.M. Levy, J.M. Prince, R. Yang Systemic inflammation and remote organ damage following bilateral femur fracture requires Toll-like receptor 4 Am J Physiol Regul Integr Comp Physiol 291 2006 R970 R976
46. F. Moeinpour, M.A. Choudhry, T. Kawasaki 17 Beta-estradiol normalizes Toll receptor 4, mitogen activated protein kinases and inflammatory response in epidermal keratinocytes following trauma-hemorrhage Mol Immunol 44 2007 3317 3323 (Pubitemid 46678204)
47. Y.C. Hsieh, M. Frink, T. Kawasaki Downregulation of TLR4-dependent ATP production is critical for estrogen-mediated immunoprotection in Kupffer cells following trauma-hemorrhage J Cell Physiol 211 2007 364 370 (Pubitemid 46580090)
48. Y.C. Hsieh, M. Frink, B.M. Thobe 17Beta-estradiol downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhage Mol Immunol 44 2007 2165 2172 (Pubitemid 46097125)
49. M.T. Ross, D.V. Grafham, A.J. Coffey The DNA sequence of the human X chromosome Nature 434 2005 325 337 (Pubitemid 40469169)
50. Z. Spolarics The X-files of inflammation: cellular mosaicism of X-linked polymorphic genes and the female advantage in the host response to injury and infection Shock 27 2007 597 604 (Pubitemid 46788157)
51. J.A. Thomas, J.L. Allen, M. Tsen Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase J Immunol 163 1999 978 984 (Pubitemid 29328110)