Why females are mosaics, x-chromosome inactivation, and sex differences in disease

Gender Medicine

Volumn 4, Issue 2, 2007, Pages 97-105

  Migeon, Barbara R ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE 3B; EPHRIN B1; TESTIS DETERMINING FACTOR;

ARTICLE; AUTOIMMUNE DISEASE; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMOSOME DELETION; CHROMOSOME TRANSLOCATION; DISEASE SEVERITY; FABRY DISEASE; GENE DELETION; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE MUTATION; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HETEROZYGOTE; HUMAN; HUNTER SYNDROME; LESCH NYHAN SYNDROME; MOLECULAR EVOLUTION; MORTALITY; NONHUMAN; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SEX CHROMOSOME MOSAICISM; SEX DIFFERENCE; SEX DIFFERENTIATION; SRY GENE; TESTIS DEVELOPMENT; X CHROMOSOME; X CHROMOSOME INACTIVATION; X CHROMOSOME LINKED DISORDER; Y CHROMOSOME;

CHROMOSOMES, HUMAN, X; FEMALE; GENETIC DISEASES, X-LINKED; GENETIC PREDISPOSITION TO DISEASE; HUMANS; LIFE EXPECTANCY; MALE; MOSAICISM; SEX CHARACTERISTICS; SEX FACTORS; X CHROMOSOME INACTIVATION;

EID: 34547842802     PISSN: 15508579     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1550-8579(07)80024-6     Document Type: Article

References (10)

1. Migeon B.R. The role of X inactivation and cellular mosaicism in women's health and sex-specific diseases. JAMA 295 (2006) 1428-1433
2. Migeon B.R. Females Are Mosaics: X Inactivation and Sex Differences in Disease (2007), Oxford University Press, New York, NY
3. Available at:. United Nations. Demographic Yearbook 1998, Table 19. Accessed (January 10, 2005). http://unstats.un.org/unsd/demographic/products/dyb/dybnat.htm
4. Ross M.T., Grafham D.V., Coffey A.J., et al. The DNA sequence of the human X chromosome. Nature 434 (2005) 325-337
5. Migeon B.R., Luo S., Jam M., and Jeppesen P. The severe phenotype of females with tiny ring X chromosomes is associated with inability of these chromosomes to undergo X inactivation. Am J Hum Genet 55 (1994) 497-504
6. Jacob F. Evolution and tinkering. Science 196 (1977) 1161-1166
7. Marahrens Y., Panning B., Dausman J., et al. XIST deficient mice are defective in dosage compensation but not spermatogenesis. Genes Dev 11 (1997) 156-166
8. Lee J.T., Strauss W.M., Dausman J.A., and Jaenisch R. A 450 kb transgene displays properties of the mammalian X-inactivation center. Cell 86 (1996) 83-94
9. Ozbalkan Z., Bagislar S., Kiraz S., et al. Skewed X chromosome inactivation in blood cells of females with scleroderma. Arthritis Rheum 52 (2005) 1564-1570
10. Childs B. Genetic Medicine: A Logic of Disease (1999), Johns Hopkins University Press, Baltimore, Md