17β-Estradiol downregulates Kupffer cell TLR4-dependent p38 MAPK pathway and normalizes inflammatory cytokine production following trauma-hemorrhage

Molecular Immunology

Volumn 44, Issue 9, 2007, Pages 2165-2172

  Hsieh, Ya Ching ^a   Frink, Michael ^a   Thobe, Bjoern M ^a   Hsu, Jun Te ^a   Choudhry, Mashkoor A ^a   Schwacha, Martin G ^a   Bland, Kirby I ^a   Chaudry, Irshad H ^a  

^a Kentucky   (United States)

Author keywords

Estrogen; Hemorrhagic shock; MIP 1 ; MIP 2; NF B

Indexed keywords

CYTOKINE; ESTRADIOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 2; MITOGEN ACTIVATED PROTEIN KINASE P38; MUTANT PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1; MESSENGER RNA; MONOKINE; TLR4 PROTEIN, MOUSE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; C3H MOUSE; CELL FUNCTION; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ESTROGEN ACTIVITY; GENE EXPRESSION REGULATION; HEMORRHAGIC SHOCK; INFLAMMATION; KUPFFER CELL; MALE; MOUSE; MOUSE MUTANT; NEGATIVE FEEDBACK; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; BLEEDING; BLOOD; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; ENZYMOLOGY; GENETICS; IMMUNOLOGY; INJURY; METABOLISM; PHOSPHORYLATION;

MUS;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CYTOKINES; DOWN-REGULATION; ESTRADIOL; HEMORRHAGE; INFLAMMATION; INTERLEUKIN-6; KUPFFER CELLS; MACROPHAGE INFLAMMATORY PROTEIN-1; MICE; MONOKINES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RNA, MESSENGER; TOLL-LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR-ALPHA; WOUNDS AND INJURIES;

EID: 33846231473     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2006.11.019     Document Type: Article

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