Structure-activity relationship of a series of non peptidic RGD integrin antagonists targeting α5β1: Part 2

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 12, 2012, Pages 4117-4121

  Delouvrié, Bénédicte ^a   Al Kadhimi, Katherine ^a   Arnould, Jean Claude ^a   Barry, Simon T ^a   Cross, Darren A E ^a   Didelot, Myriam ^a   Gavine, Paul R ^a   Germain, Hervé ^a   Harris, Craig S ^a   Hughes, Adina M ^a   Jude, David A ^a   Kendrew, Jane ^a   Lambert Van Der Brempt, Christine ^a   Lohmann, Jean Jacques ^a   Ménard, Morgan ^a   Mortlock, Andrew A ^a   Pass, Martin ^a   Rooney, Claire ^a   Vautier, Michel ^a   Vincent, Jennifer L ^a   Warin, Nicolas ^a   more..

^a ASTRAZENECA   (United Kingdom)

Author keywords

Angiogenesis; Integrin 5 1 antagonist; RGD integrin; Zwitterion

Indexed keywords

AMIDE; ARGINYLGLYCYLASPARTIC ACID; TYROSINE; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 5; VERY LATE ACTIVATION ANTIGEN 5 ANTAGONIST;

ARTICLE; CELL ADHESION; CONTROLLED STUDY; DRUG BINDING; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; IC 50; STRUCTURE ACTIVITY RELATION;

CELL ADHESION; CELL SURVIVAL; FIBRINOGEN; FIBRONECTINS; HUMANS; INTEGRIN ALPHA5BETA1; K562 CELLS; MODELS, MOLECULAR; MOLECULAR MIMICRY; OLIGOPEPTIDES; SERUM ALBUMIN; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EID: 84861576474     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.04.061     Document Type: Article

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