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Volumn 13, Issue 5, 2012, Pages 6303-6319

Deleterious effects of high dose connexin 43 mimetic peptide infusion after cerebral ischaemia in near-term fetal sheep

Author keywords

Connexins; Fetus; Gap junctions; Hemichannels; Ischaemia; Mimetic peptide

Indexed keywords

CONNEXIN 43; PEPTIDOMIMETIC AGENT; OLIGOPEPTIDE; VALYL-ASPARTYL-CYSTEINYL-PHENYLALANYL-LEUCYL-SERYL-ARGINYL-PROLYL-THREONYL-GLUTAMYL-LYSYL-THREONINE;

EID: 84861557254     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms13056303     Document Type: Article
Times cited : (36)

References (67)
  • 1
    • 0033813820 scopus 로고    scopus 로고
    • Hypoxic-ischemic encephalopathy
    • Vannucci, R.C. Hypoxic-ischemic encephalopathy. Am. J. Perinatol. 2000, 17, 113-120.
    • (2000) Am. J. Perinatol , vol.17 , pp. 113-120
    • Vannucci, R.C.1
  • 2
    • 77149149663 scopus 로고    scopus 로고
    • Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: Synthesis and meta-analysis of trial data
    • doi:10.1136/bmj.c363
    • Edwards, A.D.; Brocklehurst, P.; Gunn, A.J.; Halliday, H.; Juszczak, E.; Levene, M.; Strohm, B.; Thoresen, M.; Whitelaw, A.; Azzopardi, D. Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: Synthesis and meta-analysis of trial data. Br. Med. J. 2010, 340,doi:10.1136/bmj.c363.
    • (2010) Br. Med. J , vol.340
    • Edwards, A.D.1    Brocklehurst, P.2    Gunn, A.J.3    Halliday, H.4    Juszczak, E.5    Levene, M.6    Strohm, B.7    Thoresen, M.8    Whitelaw, A.9    Azzopardi, D.10
  • 3
    • 0031837894 scopus 로고    scopus 로고
    • Temporal and anatomical variations of brain water apparent diffusion coefficient in perinatal cerebral hypoxic-ischemic injury: Relationships to cerebral energy metabolism
    • Thornton, J.S.; Ordidge, R.J.; Penrice, J.; Cady, E.B.; Amess, P.N.; Punwani, S.; Clemence, M.; Wyatt, J.S. Temporal and anatomical variations of brain water apparent diffusion coefficient in perinatal cerebral hypoxic-ischemic injury: Relationships to cerebral energy metabolism. Magn. Reson. Med. 1998, 39, 920-927.
    • (1998) Magn. Reson. Med , vol.39 , pp. 920-927
    • Thornton, J.S.1    Ordidge, R.J.2    Penrice, J.3    Cady, E.B.4    Amess, P.N.5    Punwani, S.6    Clemence, M.7    Wyatt, J.S.8
  • 4
    • 0026515608 scopus 로고
    • Outcome after ischemia in the developing sheep brain: An electroencephalographic and histological study
    • Williams, C.E.; Gunn, A.J.; Mallard, C.; Gluckman, P.D. Outcome after ischemia in the developing sheep brain: An electroencephalographic and histological study. Ann. Neurol. 1992, 31, 14-21.
    • (1992) Ann. Neurol , vol.31 , pp. 14-21
    • Williams, C.E.1    Gunn, A.J.2    Mallard, C.3    Gluckman, P.D.4
  • 8
    • 23844440193 scopus 로고    scopus 로고
    • Gap junction blockage limits intercellular spreading of astrocytic apoptosis induced by metabolic depression
    • Nodin, C.; Nilsson, M.; Blomstrand, F. Gap junction blockage limits intercellular spreading of astrocytic apoptosis induced by metabolic depression. J. Neurochem. 2005, 94, 1111-1123.
    • (2005) J. Neurochem , vol.94 , pp. 1111-1123
    • Nodin, C.1    Nilsson, M.2    Blomstrand, F.3
  • 9
    • 0030669472 scopus 로고    scopus 로고
    • Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke
    • Rawanduzy, A.; Hansen, A.; Hansen, T.W.; Nedergaard, M. Effective reduction of infarct volume by gap junction blockade in a rodent model of stroke. J. Neurosurg. 1997, 87, 916-920.
    • (1997) J. Neurosurg , vol.87 , pp. 916-920
    • Rawanduzy, A.1    Hansen, A.2    Hansen, T.W.3    Nedergaard, M.4
  • 11
    • 2442707974 scopus 로고    scopus 로고
    • Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes
    • Nakase, T.; Sohl, G.; Theis, M.; Willecke, K.; Naus, C.C. Increased apoptosis and inflammation after focal brain ischemia in mice lacking connexin43 in astrocytes. Am. J. Pathol. 2004, 164, 2067-2075.
    • (2004) Am. J. Pathol , vol.164 , pp. 2067-2075
    • Nakase, T.1    Sohl, G.2    Theis, M.3    Willecke, K.4    Naus, C.C.5
  • 12
    • 33748864085 scopus 로고    scopus 로고
    • Enhanced connexin 43 immunoreactivity in penumbral areas in the human brain following ischemia
    • Nakase, T.; Yoshida, Y.; Nagata, K. Enhanced connexin 43 immunoreactivity in penumbral areas in the human brain following ischemia. Glia 2006, 54, 369-375.
    • (2006) Glia , vol.54 , pp. 369-375
    • Nakase, T.1    Yoshida, Y.2    Nagata, K.3
  • 14
    • 0029800089 scopus 로고    scopus 로고
    • Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells
    • Li, H.; Liu, T.F.; Lazrak, A.; Peracchia, C.; Goldberg, G.S.; Lampe, P.D.; Johnson, R.G. Properties and regulation of gap junctional hemichannels in the plasma membranes of cultured cells. J. Cell Biol. 1996, 134, 1019-1030.
    • (1996) J. Cell Biol , vol.134 , pp. 1019-1030
    • Li, H.1    Liu, T.F.2    Lazrak, A.3    Peracchia, C.4    Goldberg, G.S.5    Lampe, P.D.6    Johnson, R.G.7
  • 15
    • 0033745550 scopus 로고    scopus 로고
    • Metabolic inhibition activates a non-selective current through connexin hemichannels in isolated ventricular myocytes
    • Kondo, R.P.; Wang, S.Y.; John, S.A.; Weiss, J.N.; Goldhaber, J.I. Metabolic inhibition activates a non-selective current through connexin hemichannels in isolated ventricular myocytes. J. Mol. Cell. Cardiol. 2000, 32, 1859-1872.
    • (2000) J. Mol. Cell. Cardiol , vol.32 , pp. 1859-1872
    • Kondo, R.P.1    Wang, S.Y.2    John, S.A.3    Weiss, J.N.4    Goldhaber, J.I.5
  • 16
    • 0037039391 scopus 로고    scopus 로고
    • Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture
    • Contreras, J.E.; Sanchez, H.A.; Eugenin, E.A.; Speidel, D.; Theis, M.; Willecke, K.; Bukauskas, F.F.; Bennett, M.V.; Saez, J.C. Metabolic inhibition induces opening of unapposed connexin 43 gap junction hemichannels and reduces gap junctional communication in cortical astrocytes in culture. Proc. Natl. Acad. Sci. USA 2002, 99, 495-500.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 495-500
    • Contreras, J.E.1    Sanchez, H.A.2    Eugenin, E.A.3    Speidel, D.4    Theis, M.5    Willecke, K.6    Bukauskas, F.F.7    Bennett, M.V.8    Saez, J.C.9
  • 18
    • 75849165091 scopus 로고    scopus 로고
    • Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels
    • Orellana, J.A.; Hernandez, D.E.; Ezan, P.; Velarde, V.; Bennett, M.V.; Giaume, C.; Saez, J.C. Hypoxia in high glucose followed by reoxygenation in normal glucose reduces the viability of cortical astrocytes through increased permeability of connexin 43 hemichannels. Glia 2010, 58, 329-343.
    • (2010) Glia , vol.58 , pp. 329-343
    • Orellana, J.A.1    Hernandez, D.E.2    Ezan, P.3    Velarde, V.4    Bennett, M.V.5    Giaume, C.6    Saez, J.C.7
  • 20
    • 0037531231 scopus 로고    scopus 로고
    • Functional hemichannels in astrocytes: A novel mechanism of glutamate release
    • Ye, Z.C.; Wyeth, M.S.; Baltan-Tekkok, S.; Ransom, B.R. Functional hemichannels in astrocytes: A novel mechanism of glutamate release. J. Neurosci. 2003, 23, 3588-3596.
    • (2003) J. Neurosci , vol.23 , pp. 3588-3596
    • Ye, Z.C.1    Wyeth, M.S.2    Baltan-Tekkok, S.3    Ransom, B.R.4
  • 22
    • 0034611012 scopus 로고    scopus 로고
    • Physiological role of gap-junctional hemichannels. Extracellular calcium-dependent isosmotic volume regulation
    • Quist, A.P.; Rhee, S.K.; Lin, H.; Lal, R. Physiological role of gap-junctional hemichannels. Extracellular calcium-dependent isosmotic volume regulation. J. Cell Biol. 2000, 148, 1063-1074.
    • (2000) J. Cell Biol , vol.148 , pp. 1063-1074
    • Quist, A.P.1    Rhee, S.K.2    Lin, H.3    Lal, R.4
  • 23
    • 36249018967 scopus 로고    scopus 로고
    • Release of ATP in the central nervous system during systemic inflammation: Real-time measurement in the hypothalamus of conscious rabbits
    • Gourine, A.V.; Dale, N.; Llaudet, E.; Poputnikov, D.M.; Spyer, K.M.; Gourine, V.N. Release of ATP in the central nervous system during systemic inflammation: Real-time measurement in the hypothalamus of conscious rabbits. J. Physiol. 2007, 585, 305-316.
    • (2007) J. Physiol , vol.585 , pp. 305-316
    • Gourine, A.V.1    Dale, N.2    Llaudet, E.3    Poputnikov, D.M.4    Spyer, K.M.5    Gourine, V.N.6
  • 27
    • 0014951530 scopus 로고
    • Timing of neuroblast multiplication in developing human brain
    • Dobbing, J.; Sands, J. Timing of neuroblast multiplication in developing human brain. Nature 1970, 226, 639-640.
    • (1970) Nature , vol.226 , pp. 639-640
    • Dobbing, J.1    Sands, J.2
  • 29
    • 0025328806 scopus 로고
    • Delayed seizures occurring with hypoxic-ischemic encephalopathy in the fetal sheep
    • Williams, C.E.; Gunn, A.J.; Synek, B.; Gluckman, P.D. Delayed seizures occurring with hypoxic-ischemic encephalopathy in the fetal sheep. Pediatr. Res. 1990, 27, 561-565.
    • (1990) Pediatr. Res , vol.27 , pp. 561-565
    • Williams, C.E.1    Gunn, A.J.2    Synek, B.3    Gluckman, P.D.4
  • 31
    • 70349262525 scopus 로고    scopus 로고
    • Early EEG findings in hypoxic-ischemic encephalopathy predict outcomes at 2 years
    • Murray, D.M.; Boylan, G.B.; Ryan, C.A.; Connolly, S. Early EEG findings in hypoxic-ischemic encephalopathy predict outcomes at 2 years. Pediatrics 2009, 124, e459-e467.
    • (2009) Pediatrics , vol.124
    • Murray, D.M.1    Boylan, G.B.2    Ryan, C.A.3    Connolly, S.4
  • 32
    • 0025906865 scopus 로고
    • Time course of intracellular edema and epileptiform activity following prenatal cerebral ischemia in sheep
    • Williams, C.E.; Gunn, A.; Gluckman, P.D. Time course of intracellular edema and epileptiform activity following prenatal cerebral ischemia in sheep. Stroke 1991, 22, 516-521.
    • (1991) Stroke , vol.22 , pp. 516-521
    • Williams, C.E.1    Gunn, A.2    Gluckman, P.D.3
  • 35
    • 34548203204 scopus 로고    scopus 로고
    • Astrocytes potentiate transmitter release at single hippocampal synapses
    • Perea, G.; Araque, A. Astrocytes potentiate transmitter release at single hippocampal synapses. Science 2007, 317, 1083-1086.
    • (2007) Science , vol.317 , pp. 1083-1086
    • Perea, G.1    Araque, A.2
  • 39
    • 33646199097 scopus 로고    scopus 로고
    • Synaptic scaling mediated by glial TNF-α
    • Stellwagen, D.; Malenka, R.C. Synaptic scaling mediated by glial TNF-α. Nature 2006, 440, 1054-1059.
    • (2006) Nature , vol.440 , pp. 1054-1059
    • Stellwagen, D.1    Malenka, R.C.2
  • 40
    • 0842283997 scopus 로고    scopus 로고
    • Intracellular astrocyte calcium waves in situ increase the frequency of spontaneous AMPA receptor currents in CA1 pyramidal neurons
    • Fiacco, T.A.; McCarthy, K.D. Intracellular astrocyte calcium waves in situ increase the frequency of spontaneous AMPA receptor currents in CA1 pyramidal neurons. J. Neurosci. 2004, 24, 722-732.
    • (2004) J. Neurosci , vol.24 , pp. 722-732
    • Fiacco, T.A.1    McCarthy, K.D.2
  • 41
    • 0034743201 scopus 로고    scopus 로고
    • Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation
    • Parri, H.R.; Gould, T.M.; Crunelli, V. Spontaneous astrocytic Ca2+ oscillations in situ drive NMDAR-mediated neuronal excitation. Nat. Neurosci. 2001, 4, 803-812.
    • (2001) Nat. Neurosci , vol.4 , pp. 803-812
    • Parri, H.R.1    Gould, T.M.2    Crunelli, V.3
  • 43
    • 0032247897 scopus 로고    scopus 로고
    • Astrocyte-mediated potentiation of inhibitory synaptic transmission
    • Kang, J.; Jiang, L.; Goldman, S.A.; Nedergaard, M. Astrocyte-mediated potentiation of inhibitory synaptic transmission. Nat. Neurosci. 1998, 1, 683-692.
    • (1998) Nat. Neurosci , vol.1 , pp. 683-692
    • Kang, J.1    Jiang, L.2    Goldman, S.A.3    Nedergaard, M.4
  • 46
    • 38949187924 scopus 로고    scopus 로고
    • Should amplitude-integrated electroencephalography be used to identify infants suitable for hypothermic neuroprotection?
    • Sarkar, S.; Barks, J.D.; Donn, S.M. Should amplitude-integrated electroencephalography be used to identify infants suitable for hypothermic neuroprotection? J. Perinatol. 2008, 28, 117-122.
    • (2008) J. Perinatol , vol.28 , pp. 117-122
    • Sarkar, S.1    Barks, J.D.2    Donn, S.M.3
  • 47
    • 84857975752 scopus 로고    scopus 로고
    • Limited predictive value of early changes in EEG spectral power for neural injury after asphyxia in preterm fetal sheep
    • Keogh, M.J.; Drury, P.P.; Bennet, L.; Davidson, J.O.; Mathai, S.; Gunn, E.R.; Booth, L.C.; Gunn, A.J. Limited predictive value of early changes in EEG spectral power for neural injury after asphyxia in preterm fetal sheep. Pediatr. Res. 2012, 71, 345-353.
    • (2012) Pediatr. Res , vol.71 , pp. 345-353
    • Keogh, M.J.1    Drury, P.P.2    Bennet, L.3    Davidson, J.O.4    Mathai, S.5    Gunn, E.R.6    Booth, L.C.7    Gunn, A.J.8
  • 49
    • 37149018110 scopus 로고    scopus 로고
    • Intracellular calcium regulation of connexin43
    • Lurtz, M.M.; Louis, C.F. Intracellular calcium regulation of connexin43. Am. J. Physiol. Cell physiol. 2007, 293, C1806-C1813.
    • (2007) Am. J. Physiol. Cell Physiol , vol.293
    • Lurtz, M.M.1    Louis, C.F.2
  • 50
    • 0026621598 scopus 로고
    • The influence of moderate hypothermia on cellular calcium uptake in complete ischaemia: Implications for the excitotoxic hypothesis
    • Kristian, T.; Katsura, K.; Siesjo, B.K. The influence of moderate hypothermia on cellular calcium uptake in complete ischaemia: Implications for the excitotoxic hypothesis. Acta Physiol. Scand. 1992, 146, 531-532.
    • (1992) Acta Physiol. Scand , vol.146 , pp. 531-532
    • Kristian, T.1    Katsura, K.2    Siesjo, B.K.3
  • 51
    • 48449084169 scopus 로고    scopus 로고
    • Connexin 43 mimetic peptides reduce swelling, astrogliosis, and neuronal cell death after spinal cord injury
    • O'Carroll, S.J.; Alkadhi, M.; Nicholson, L.F.; Green, C.R. Connexin 43 mimetic peptides reduce swelling, astrogliosis, and neuronal cell death after spinal cord injury. Cell Commun. Adhes. 2008, 15, 27-42.
    • (2008) Cell Commun. Adhes , vol.15 , pp. 27-42
    • O'Carroll, S.J.1    Alkadhi, M.2    Nicholson, L.F.3    Green, C.R.4
  • 52
    • 33749139551 scopus 로고    scopus 로고
    • Cortical recruitment patterns in children born prematurely compared with control subjects during a passive listening functional magnetic resonance imaging task
    • Ment, L.R.; Peterson, B.S.; Vohr, B.; Allan, W.; Schneider, K.C.; Lacadie, C.; Katz, K.H.; Maller-Kesselman, J.; Pugh, K.; Duncan, C.C.; et al. Cortical recruitment patterns in children born prematurely compared with control subjects during a passive listening functional magnetic resonance imaging task. J. Pediatr. 2006, 149, 490-498.
    • (2006) J. Pediatr , vol.149 , pp. 490-498
    • Ment, L.R.1    Peterson, B.S.2    Vohr, B.3    Allan, W.4    Schneider, K.C.5    Lacadie, C.6    Katz, K.H.7    Maller-Kesselman, J.8    Pugh, K.9    Duncan, C.C.10
  • 53
    • 84859802065 scopus 로고    scopus 로고
    • Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channels
    • Desplantez, T.; Verma, V.; Leybaert, L.; Evans, W.H.; Weingart, R. Gap26, a connexin mimetic peptide, inhibits currents carried by connexin43 hemichannels and gap junction channels. Pharmacol. Res. 2012, 65, 546-552.
    • (2012) Pharmacol. Res , vol.65 , pp. 546-552
    • Desplantez, T.1    Verma, V.2    Leybaert, L.3    Evans, W.H.4    Weingart, R.5
  • 55
    • 77955467019 scopus 로고    scopus 로고
    • Connexin 43 mimetic peptide Gap26 confers protection to intact heart against myocardial ischemia injury
    • Hawat, G.; Benderdour, M.; Rousseau, G.; Baroudi, G. Connexin 43 mimetic peptide Gap26 confers protection to intact heart against myocardial ischemia injury. Pflugers Archiv. Eur. J. Physiol. 2010, 460, 583-592.
    • (2010) Pflugers Archiv. Eur. J. Physiol , vol.460 , pp. 583-592
    • Hawat, G.1    Benderdour, M.2    Rousseau, G.3    Baroudi, G.4
  • 58
    • 33745003688 scopus 로고    scopus 로고
    • The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus
    • Wallraff, A.; Kohling, R.; Heinemann, U.; Theis, M.; Willecke, K.; Steinhauser, C. The impact of astrocytic gap junctional coupling on potassium buffering in the hippocampus. J. Neurosci. 2006, 26, 5438-5447.
    • (2006) J. Neurosci , vol.26 , pp. 5438-5447
    • Wallraff, A.1    Kohling, R.2    Heinemann, U.3    Theis, M.4    Willecke, K.5    Steinhauser, C.6
  • 60
    • 0015505739 scopus 로고
    • Potassium-selective microelectrodes used for measuring the extracellular brain potassium during spreading depression and anoxic depolarization in rats
    • Vyskocil, F.; Kritz, N.; Bures, J. Potassium-selective microelectrodes used for measuring the extracellular brain potassium during spreading depression and anoxic depolarization in rats. Brain Res. 1972, 39, 255-259.
    • (1972) Brain Res , vol.39 , pp. 255-259
    • Vyskocil, F.1    Kritz, N.2    Bures, J.3
  • 61
    • 0029927343 scopus 로고    scopus 로고
    • Metabolic coupling between glia and neurons
    • Tsacopoulos, M.; Magistretti, P.J. Metabolic coupling between glia and neurons. J. Neurosci. 1996, 16, 877-885.
    • (1996) J. Neurosci , vol.16 , pp. 877-885
    • Tsacopoulos, M.1    Magistretti, P.J.2
  • 62
    • 0019842691 scopus 로고
    • Cell damage in the brain: A speculative synthesis
    • Siesjo, B.K. Cell damage in the brain: A speculative synthesis. J. Cereb. Blood Flow Metab. 1981, 1, 155-185.
    • (1981) J. Cereb. Blood Flow Metab , vol.1 , pp. 155-185
    • Siesjo, B.K.1
  • 63
    • 0017510869 scopus 로고
    • Report of Joint Committee for Stroke Resources. IV. Brain edema in stroke
    • Katzman, R.; Clasen, R.; Klatzo, I.; Meyer, J.S.; Pappius, H.M.; Waltz, A.G. Report of Joint Committee for Stroke Resources. IV. Brain edema in stroke. Stroke 1977, 8, 512-540.
    • (1977) Stroke , vol.8 , pp. 512-540
    • Katzman, R.1    Clasen, R.2    Klatzo, I.3    Meyer, J.S.4    Pappius, H.M.5    Waltz, A.G.6
  • 64
    • 0031034474 scopus 로고    scopus 로고
    • Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs
    • Gunn, A.J.; Gunn, T.R.; de Haan, H.H.; Williams, C.E.; Gluckman, P.D. Dramatic neuronal rescue with prolonged selective head cooling after ischemia in fetal lambs. J. Clin. Invest. 1997, 99, 248-256.
    • (1997) J. Clin. Invest , vol.99 , pp. 248-256
    • Gunn, A.J.1    Gunn, T.R.2    de Haan, H.H.3    Williams, C.E.4    Gluckman, P.D.5
  • 67
    • 0027479352 scopus 로고
    • Ictal and interictal electrographic seizure durations in preterm and term neonates
    • Scher, M.S.; Hamid, M.Y.; Steppe, D.A.; Beggarly, M.E.; Painter, M.J. Ictal and interictal electrographic seizure durations in preterm and term neonates. Epilepsia 1993, 34, 284-288.
    • (1993) Epilepsia , vol.34 , pp. 284-288
    • Scher, M.S.1    Hamid, M.Y.2    Steppe, D.A.3    Beggarly, M.E.4    Painter, M.J.5


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