Flap endonucleases pass 5′-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5′-ends

Nucleic Acids Research

Volumn 40, Issue 10, 2012, Pages 4507-4519

  Patel, Nikesh ^a   Atack, John M ^a   Finger, L David ^a   Exell, Jack C ^a   Thompson, Peter ^a,d   Tsutakawa, Susan ^b   Tainer, John A ^b,c   Williams, David M ^a   Grasby, Jane A ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d Leeds Innovation Centre   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FLAP ENDONUCLEASE; OKAZAKI FRAGMENT; STREPTAVIDIN;

ARTICLE; BIOTINYLATION; CATALYSIS; CONTROLLED STUDY; DNA TEMPLATE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; PRIORITY JOURNAL; PROTEIN CROSS LINKING; PROTEIN FOLDING; PROTEIN HYDROLYSIS; PROTEIN SECONDARY STRUCTURE; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; BIOCATALYSIS; DNA; FLAP ENDONUCLEASES; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; STREPTAVIDIN; SUBSTRATE SPECIFICITY;

EID: 84861557214     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks051     Document Type: Article

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