The identification and optimization of a N-hydroxy urea series of flap endonuclease 1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 2, 2005, Pages 277-281

  Tumey, L Nathan ^a   Bom, David ^a   Huck, Bayard ^a   Gleason, Elizabeth ^a   Wang, Jianmin ^a   Silver, Daniel ^a   Brunden, Kurt ^a   Boozer, Sherry ^a   Rundlett, Stephen ^a   Sherf, Bruce ^a   Murphy, Steven ^a   Dent, Tom ^a   Leventhal, Christina ^a   Bailey, Andrew ^a   Harrington, John ^a   Bennani, Youssef L ^a  

^a ATHERSYS INC   (United States)

Author keywords

Cancer; DNA repair; Endonuclease; FEN1

Indexed keywords

ANTINEOPLASTIC AGENT; ATH 13974; ENZYME; ENZYME INHIBITOR; FLAP ENDONUCLEASE 1; FLAP ENDONUCLEASE 1 INHIBITOR; MESYLIC ACID METHYL ESTER; TEMOZOLOMIDE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BLADDER CANCER; CANCER CELL CULTURE; CHEMOTHERAPY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DRUG IDENTIFICATION; DRUG STRUCTURE; ENZYME ACTIVITY; EXCISION REPAIR; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; XERODERMA PIGMENTOSUM;

CELL LINE, TUMOR; DACARBAZINE; DNA DAMAGE; ENZYME INHIBITORS; FLAP ENDONUCLEASES; HUMANS; METHYL METHANESULFONATE; STRUCTURE-ACTIVITY RELATIONSHIP; UREA; URINARY BLADDER NEOPLASMS; XERODERMA PIGMENTOSUM;

MAMMALIA; ZIZIPHUS MAURITIANA;

EID: 10644234537     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.10.086     Document Type: Article

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