Genetic and immunological evidence implicates interleukin 6 as a susceptibility gene for leprosy type 2 reaction

Journal of Infectious Diseases

Volumn 205, Issue 9, 2012, Pages 1417-1424

  Sousa, Ana Lucia M ^a   Fava, Vinicius M ^b   Sampaio, Lucas H ^a   Martelli, Celina Maria T ^a   Costa, Mauricio B ^a   Mira, Marcelo T ^b   Stefani, Mariane M A ^a  

^a FEDERAL UNIVERSITY OF GOIÁS   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6;

ADULT; AGED; ALLELE; ARTICLE; BRAZIL; CASE CONTROL STUDY; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; GENE; GENE FUNCTION; GENE LOCUS; GENETIC ASSOCIATION; GENETIC MARKER; GENETIC RISK; GENETIC SELECTION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HUMAN; INTERLEUKIN 6 GENE; LEPROSY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; BRAZIL; CASE-CONTROL STUDIES; FEMALE; FOLLOW-UP STUDIES; GENETIC LOCI; GENETIC MARKERS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-6; LEPROSY; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; SELECTION, GENETIC; YOUNG ADULT;

EID: 84861553014     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jis208     Document Type: Article

References (42)

1. Global leprosy situation, 2010. Wkly Epidemiol Rec 2010; 85:337-48.
2. Ridley DS, JoplingWH. Classification of leprosy according to immunity: a five-group system. Int J Lepr Other Mycobact Dis 1966; 34:255-73.
3. Britton WJ, Lockwood DN. Leprosy. Lancet 2004; 363:1209-19.
4. van Brakel WH, Nicholls PG, Das L, et al. The INFIR Cohort Study: investigating prediction, detection and pathogenesis of neuropathy and reactions in leprosy. Methods and baseline results of a cohort of multibacillary leprosy patients in north India. Lepr Rev 2005; 76:14-34.
5. Scollard DM, Adams LB, Gillis TP, Krahenbuhl JL, Truman RW, Williams DL. The continuing challenges of leprosy. Clin Microbiol Rev 2006; 19:338-81.
6. Kar HK, Sharma P. New lesions after MDT in PB and MB leprosy: a report of 28 cases. Indian J Lepr 2008; 80:247-55.
7. Stefani MM, Martelli CM, Gillis TP, Krahenbuhl JL. In situ type 1 cytokine gene expression and mechanisms associated with early leprosy progression. J Infect Dis 2003; 188:1024-31.
8. Ranque B, Nguyen Van T, Vu Hong T, et al. Age is an important risk factor for onset and sequelae of reversal reactions in Vietnamese patients with leprosy. Clin Infect Dis 2007; 44:33-40.
9. van Brakel WH, Khawas IB. Nerve function impairment in leprosy: an epidemiological and clinical studydPart 2: results of steroid treatment. Lepr Rev 1996; 67:104-18.
10. Pocaterra L, Jain S, Reddy R, et al. Clinical course of erythema nodosum leprosum: an 11-year cohort study in Hyderabad, India. Am J Trop Med Hyg 2006; 74:868-79.
11. Monot M, Honore N, Garnier T, et al. Comparative genomic and phylogeographic analysis of Mycobacterium leprae. NatGenet 2009; 41:1282-9.
12. Bochud PY, Hawn TR, Siddiqui MR, et al. Toll like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy. J Infect Dis 2008; 197:253-61.
13. Misch EA, Macdonald M, Ranjit C, et al. Human TLR1 deficiency is associated with impaired mycobacterial signaling and protection from leprosy reversal reaction. PLoS Negl Trop Dis 2008; 2:e231.
14. Wong SH, Gochhait S, Malhotra D, et al. Leprosy and the adaptation of human toll-like receptor 1. PLoS Pathog 2010; 6:e1000979.
15. Schuring RP, Hamann L, Faber WR, et al. Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions. J Infect Dis 2009; 199:1816-9.
16. Zhang FR, Huang W, Chen SM, et al. Genomewide association study of leprosy. N Engl J Med 2009; 361:2609-18.
17. Berrington WR, Macdonald M, Khadge S, et al. Common polymorphisms in the NOD2 gene region are associated with leprosy and its reactive states. J Infect Dis 2010; 201:1422-35.
18. Stefani MM, Guerra JG, Sousa AL, et al. Potential plasma markers of type 1 and type 2 leprosy reactions: a preliminary report. BMC Infect Dis 2009; 9:75.
19. Moraes MO, Sarno EN, Almeida AS, et al. Cytokine mRNA expression in leprosy: a possible role for interferon-gamma and interleukin-12 in reactions (RR and ENL). Scand J Immunol 1999; 50:541-9.
20. OchoaMT, Valderrama L, Ochoa A, et al. Lepromatous and tuberculoid leprosy: clinical presentation and cytokine responses. Int J Dermatol 1996; 35:786-90.
21. Belgaumkar VA, Gokhale NR, Mahajan PM, Bharadwaj R, Pandit DP, Deshpande S. Circulating cytokine profiles in leprosy patients. Lepr Rev 2007; 78:223-30.
22. John SW, Weitzner G, Rozen R, Scriver CR. A rapid procedure for extracting genomic DNA from leukocytes. Nucleic Acids Res 1991; 19:408.
23. Lee LG, Connell CR, Bloch W. Allelic discrimination by nicktranslation PCR with fluorogenic probes. Nucleic Acids Res 1993; 21:3761-6.
24. Trevilatto PC, Scarel-Caminaga RM, de Brito RB Jr, de Souza AP, Line SR. Polymorphism at position 2174 of IL-6 gene is associated with susceptibility to chronic periodontitis in a Caucasian Brazilian population. J Clin Periodontol 2003; 30:438-42.
25. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21:263-5.
26. Fishman D, Faulds G, Jeffery R, et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998; 102:1369-76.
27. Anvari M, Khalilzadeh O, Esteghamati A, et al. Graves' disease and gene polymorphism of TNF-alpha, IL-2, IL-6, IL-12, and IFN-gamma. Endocrine 2010; 37:344-8.
28. Nibali L, Griffiths GS, Donos N, et al. Association between interleukin-6 promoter haplotypes and aggressive periodontitis. J Clin Periodontol 2008; 35:193-8.
29. Nibali L, D'Aiuto F, Donos N, et al. Association between periodontitis and common variants in the promoter of the interleukin-6 gene. Cytokine 2009; 45:50-4.
30. Cussigh A, Falleti E, Fabris C, et al. Interleukin 6 promoter polymorphisms influence the outcome of chronic hepatitis C. Immunogenetics 2011; 63:33-41.
31. Kristiansen OP, Nolsøe RL, Larsen L, et al. Association of a functional 17 beta-estradiol sensitive IL6-174G/C promoter polymorphism with early-onset type 1 diabetes in females. Hum Mol Genet 2003; 12: 1101-10.
32. Gillespie KM, Nolsøe R, Betin VM, et al. Is puberty an accelerator of type 1 diabetes in IL6-174CC females? Diabetes 2005; 54:1245-8.
33. Qi L, van Dam RM, Meigs JB, Manson JE, Hunter D, Hu FB. Genetic variation in IL6 gene and type 2 diabetes: tagging-SNP haplotype analysis in large-scale case-control study and meta-analysis. Hum Mol Genet 2006; 15:1914-20.
34. Castellucci L, Menezes E, Oliveira J, et al. IL6-174 G/C promoter polymorphism influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil. J Infect Dis 2006; 194:519-27.
35. Sobti RC, Berhane N, Mahedi SA, et al. Polymorphisms of IL-6 174 G/C, IL-10-592 C/A and risk of HIV/AIDS among North Indian population. Mol Cell Biochem 2010; 337:145-52.
36. Torres OA, Calzada JE, Beraun Y, et al. Lack of association between IL-6-174G/C gene polymorphism and Chagas disease. Tissue Antigens 2010; 76:131-4.
37. Guerreiro CS, Ferreira P, Tavares L, et al. Fatty acids, IL6, and TNF alpha polymorphisms: an example of nutrigenetics in Crohn's disease. Am J Gastroenterol 2009; 104:2241-9.
38. Barrett JC, Hansoul S, Nicolae DL, et al. Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease. Nat Genet 2008; 40:955-62.
39. Le Bourhis L, Benko S, Girardin SE. Nod1 and Nod2 in innate immunity and human inflammatory disorders. Biochem Soc Trans 2007; 35:1479-84.
40. Morahan G, Kaur G, Singh M, et al. Association of variants in the IL12B gene with leprosy and tuberculosis. Tissue Antigens 2007; 69(Suppl 1): 234-6.
41. Behr MA, Schurr E. Mycobacteria in Crohn's disease: a persistent hypothesis. Inflamm Bowel Dis 2006; 12:1000-4.
42. Fisman EZ, Tenenbaum A. The ubiquitous interleukin-6: a time for reappraisal. Cardiovasc Diabetol 2010; 9:62.