Lack of association between IL-6 -174G/C gene polymorphism and Chagas disease

Tissue Antigens

Volumn 76, Issue 2, 2010, Pages 131-134

  Torres, O A ^a   Calzada, J E ^b   Beraun Y ^a   Morillo, C A ^c   Gonzalez A ^a   Gonzalez C I ^d   Martin J ^a  

^a INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^b Instituto Conmemorativo Gorgas de Estudios de la Salud ICGES   (Panama)

^c FUNDACIÓN CARDIOVASCULAR DE COLOMBIA   (Colombia)

^d UNIVERSIDAD INDUSTRIAL DE SANTANDER   (Colombia)

Author keywords

association study; Chagas disease; genetics; IL 6 gene; single nucleotide polymorphism; Trypanosoma cruzi

Indexed keywords

INTERLEUKIN 6;

ADULT; AGED; ALLELE; ARTICLE; CARDIOMYOPATHY; CHAGAS DISEASE; COLOMBIA; CONTROLLED STUDY; DISEASE SEVERITY; ENDEMIC DISEASE; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; INFECTION RESISTANCE; INFECTION SENSITIVITY; MAJOR CLINICAL STUDY; MALE; PERU; PRIORITY JOURNAL; SERODIAGNOSIS; SINGLE NUCLEOTIDE POLYMORPHISM; TRYPANOSOMA CRUZI;

ADULT; AGED; ALLELES; CASE-CONTROL STUDIES; CHAGAS CARDIOMYOPATHY; CHAGAS DISEASE; COHORT STUDIES; COLOMBIA; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-6; MALE; MIDDLE AGED; PERU; POLYMORPHISM, SINGLE NUCLEOTIDE; YOUNG ADULT;

TRYPANOSOMA CRUZI;

EID: 77954322159     PISSN: 00012815     EISSN: 13990039     Source Type: Journal    
DOI: 10.1111/j.1399-0039.2010.01478.x     Document Type: Article

References (20)

1. Moncayo A. Chagas disease: current epidemiological trends after the interruption of vectorial and transfusional transmission in the Southern Cone countries. Mem Inst Oswaldo Cruz 2003 : 98 : 577 591.
2. Prata A. Clinical and epidemiological aspects of Chagas disease. Lancet Infect Dis 2001 : 1 : 92 100.
3. Moncayo A, Silveira AC. Current epidemiological trends for Chagas disease in Latin America and future challenges in epidemiology, surveillance and health policy. Mem Inst Oswaldo Cruz 2009 : 104 (Suppl 1): 17 30.
4. Calzada JE, Nieto A, Beraun Y, Martin J. Chemokine receptor CCR5 polymorphisms and Chagas' disease cardiomyopathy. Tissue Antigens 2001 : 58 : 154 158. (Pubitemid 33078145)
5. Torres OA, Calzada JE, Beraun Y et al. Association of the macrophage migration inhibitory factor -173G/C polymorphism with Chagas disease. Hum Immunol 2009 : 70 : 543 546.
6. Nieto A, Beraun Y, Collado MD et al. HLA haplotypes are associated with differential susceptibility to Trypanosoma cruzi infection. Tissue Antigens 2000 : 55 : 195 198.
7. Diehl S, Rincon M. The two faces of IL-6 on Th1/Th2 differentiation. Mol Immunol 2002 : 39 : 531 536.
8. Kishimoto T. Interleukin-6: from basic science to medicine - 40 years in immunology. Annu Rev Immunol 2005 : 23 : 1 21.
9. Gao W, Pereira MA. Interleukin-6 is required for parasite specific response and host resistance to Trypanosoma cruzi. Int J Parasitol 2002 : 32 : 167 170.
10. Lopez L, Arai K, Gimenez E et al. C-reactive protein and interleukin-6 serum levels increase as Chagas disease progresses towards cardiac failure. Rev Esp Cardiol 2006 : 59 : 50 6.
11. Fishman D, Faulds G, Jeffery R et al. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis. J Clin Invest 1998 : 102 : 1369 1376.
12. Terry CF, Loukaci V, Green FR. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation. J Biol Chem 2000 : 275 : 18138 18144.
13. Rocha MO, Ribeiro AL, Teixeira MM. Clinical management of chronic Chagas cardiomyopathy. Front Biosci 2003 : 8 : e44 54.
14. Bowcock AM, Kidd JR, Lathrop M et al. The human "beta-2 interferon/hepatocyte stimulating factor/interleukin-6" gene: DNA polymorphism studies and localization to chromosome 7p21. Genomics 1988 : 3 : 8 16.
15. Tanowitz HB, Gumprecht JP, Spurr D et al. Cytokine gene expression of endothelial cells infected with Trypanosoma cruzi. J Infect Dis 1992 : 166 : 598 603.
16. Saavedra E, Herrera M, Gao W, Uemura H, Pereira MA. The Trypanosoma cruzi trans-sialidase, through its COOH-terminal tandem repeat, upregulates interleukin 6 secretion in normal human intestinal microvascular endothelial cells and peripheral blood mononuclear cells. J Exp Med 1999 : 190 : 1825 1836.
17. Castellucci L, Menezes E, Oliveira J et al. IL6 -174G/C promoter polymorphism influences susceptibility to mucosal but not localized cutaneous leishmaniasis in Brazil. J Infect Dis 2006 : 194 : 519 527.
18. Budak F, Goral G, Heper, Y et al. IL-10 and IL-6 gene polymorphisms as potential host susceptibility factors in Brucellosis. Cytokine 2007 : 38 : 32 6.
19. Oral HB, Budak F, Uzaslan EK et al. Interleukin-10 (IL-10) gene polymorphism as a potential host susceptibility factor in tuberculosis. Cytokine 2006 : 35 : 143 147.
20. Henao MI, Montes C, Paris SC, Garcia LF. Cytokine gene polymorphisms in Colombian patients with different clinical presentations of tuberculosis. Tuberculosis (Edinb) 2006 : 86 : 11 9.