Synthesis and nicotinic receptor activity of chemical space analogues of N -(3 R)-1-azabicyclo[2.2.2]oct-3-yl-4-chlorobenzamide (PNU-282,987) and 1,4-diazabicyclo[3.2.2]nonane-4-carboxylic acid 4-bromophenyl ester (SSR180711)

Journal of Medicinal Chemistry

Volumn 55, Issue 10, 2012, Pages 4605-4618

  Bréthous, Lise ^a   Garcia Delgado, Noemi ^a   Schwartz, Julian ^a   Bertrand, Sonia ^b   Bertrand, Daniel ^b   Reymond, Jean Louis ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b HiQScreen   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

(2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL)(4 ISOPROPYL 1,4 DIAZOCAN 1 YL)METHANONE; (4 CHLOROPHENYL)(4 ISOPROPYL 1,4 DIAZOCAN 1 YL)METHANONE; 1,4 DIAZABICYCLO[3.2.2]NONANE 4 CARBOXYLIC ACID 4 BROMOPHENYL ESTER; 2 AMINOMETHYL 1 AZABICYCLO[2.2.2]OCT 2 ENE; 4 BROMOPHENYL 2 (PIPERIDIN 1 YL)CYCLOHEXYLCARBAMATE; 4 BROMOPHENYL HEXAHYDRO 1H PYRROLO[1,2 A][1,4]DIAZEPINE 2(3H)CARBOXYLATE; 4 CHLORO N (3 QUINUCLIDINYL)BENZAMIDE; 4 CHLORO N [(HEXAHYDRO 1H PYRROLIZIN 7A YL)METHYL]BENZAMIDE; ACETYLCHOLINE BINDING PROTEIN; BINDING PROTEIN; CARBONIC ACID DERIVATIVE; CARBOXYLIC ACID; DIAMINE; HEXAHYDRO 3 METHYL 1H PYRIDO[1,2 A]PYRAZIN 2(6H) YL)[2,3 DIHYDROBENZO[B][1,4]DIOXIN 6 YL]METHANONE; N [(HEXAHYDRO 1H PYRROLIZIN 7ALPHA YL)METHYL]BENZAMIDE; N [1 (2 METHYLCYCLOPENTYL)PYRROLIDIN 3 YL]BENZO[D]THIAZOLE 6 CARBOXAMIDE; N [1 AZA BICYCLO[2.2.2]OCT 2 YLMETHYL] 4 FLUOROBENZAMIDE; N [[1 (PENT 2 YNYL)PYRROLIDIN 2 YL]METHYL]BENZO[D]THIAZOLE 6 CARBOXAMIDE; N [[1 AZA BICYCLO[2.2.2]OCT 2 EN 2 YL]METHY] 4 FLUOROBENZAMIDE; NICOTINE; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA3BETA2; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA3BETA4; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA4BETA4; NICOTINIC ACETYLCHOLINE RECEPTOR ALPHA7; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA4BETA2; OXYCARBONIC ACID; UNCLASSIFIED DRUG;

ACYLATION; ALLOSTERISM; ARTICLE; BINDING SITE; CONTROLLED STUDY; DATA BASE; DRUG SYNTHESIS; DRUG TARGETING; ELECTROPHYSIOLOGY; HUMAN; LIGAND BINDING; MOLECULAR DOCKING; MOLECULAR LIBRARY; NONHUMAN; OOCYTE; PROTEIN EXPRESSION; SCORING SYSTEM; VIRTUAL REALITY; XENOPUS;

ALLOSTERIC REGULATION; ANIMALS; BENZAMIDES; BICYCLO COMPOUNDS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; DATABASES, FACTUAL; FEMALE; HUMANS; MODELS, MOLECULAR; NICOTINIC AGONISTS; NICOTINIC ANTAGONISTS; OOCYTES; PATCH-CLAMP TECHNIQUES; RECEPTORS, NICOTINIC; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 84861521208     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300030r     Document Type: Article

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