Identification of selective norbornane-type aspartate analogue inhibitors of the glutamate transporter 1 (GLT-1) from the chemical universe generated database (GDB)

Journal of Medicinal Chemistry

Volumn 53, Issue 19, 2010, Pages 7236-7250

  Luethi, Erika ^a   Nguyen, Kong T ^a   Bürzle, Marc ^a   Blum, Lorenz C ^a   Suzuki, Yoshiro ^a   Hediger, Matthias ^a   Reymond, Jean Louis ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 6 PHENETHYLBICYCLO[2.2.1]HEPTANE 2,3 DICARBOXYLIC ACID; ASPARTIC ACID DERIVATIVE; BACTERIAL PROTEIN; GLUTAMIC ACID; GLUTAMIC ACID DERIVATIVE; LIGAND; NORBORNANE DERIVATIVE; UNCLASSIFIED DRUG; VESICULAR GLUTAMATE TRANSPORTER 1; 2-AMINO-6-PHENETHYLBICYCLO(2.2.1)HEPTANE-2,3-DICARBOXYLIC ACID; AMINO ACID; ASPARTIC ACID; EXCITATORY AMINO ACID TRANSPORTER 2; EXCITATORY AMINO ACID TRANSPORTER 3; PROTEIN BINDING;

ARTICLE; BINDING SITE; DATA BASE; DRUG IDENTIFICATION; DRUG SCREENING; IC 50; MOLECULAR DOCKING; MOLECULE; PYROCOCCUS HORIKOSHII; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; CONFORMATION; DRUG EFFECTS; FACTUAL DATABASE; FEMALE; METABOLISM; OOCYTE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; XENOPUS LAEVIS;

AMINO ACIDS, CYCLIC; ANIMALS; ASPARTIC ACID; BACTERIAL PROTEINS; DATABASES, FACTUAL; EXCITATORY AMINO ACID TRANSPORTER 2; EXCITATORY AMINO ACID TRANSPORTER 3; FEMALE; GLUTAMATES; LIGANDS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NORBORNANES; OOCYTES; PROTEIN BINDING; PYROCOCCUS HORIKOSHII; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS LAEVIS;

EID: 77957956614     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm100959g     Document Type: Article

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