Improved ion-exchanged HPLC method in mab using ph gradient and its comparison with cIEF

Journal of Liquid Chromatography and Related Technologies

Volumn 35, Issue 9, 2012, Pages 1259-1269

  Wang, Feng ^a   Peklansky, Brian ^a   Anderson, Carrie ^a   Wang, Yang ^a   Rustandi, Richard R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

acidic variant; capillary isoelectric focusing; cation exchange chromatography; CEX; cIEF; mAb; pH gradient

Indexed keywords

ACIDIC VARIANT; CAPILLARY ISOELECTRIC FOCUSING; CATION EXCHANGE CHROMATOGRAPHY; CEX; CIEF; MAB; PH-GRADIENT;

CHROMATOGRAPHY; ELECTROPHORESIS; MONOCLONAL ANTIBODIES; PH; PROTEINS; SEPARATION;

ION EXCHANGE;

IMMUNOGLOBULIN G1 MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CAPILLARY ISOELECTRIC FOCUSING; CHEMICAL ANALYSIS; CONTROLLED STUDY; CORRELATION ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTERMETHOD COMPARISON; ION EXCHANGE CHROMATOGRAPHY; MOUSE; NONHUMAN; PH;

EID: 84861505457     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826076.2011.619035     Document Type: Article

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