메뉴 건너뛰기




Volumn 25, Issue 4, 2011, Pages 1198-1207

Green tea polyphenol EGCG blunts androgen receptor function in prostate cancer

Author keywords

Androgen antagonist; Androgen receptor signaling; Androgen regulated miRNA; Hormone refractory prostate cancer

Indexed keywords

ANDROGEN RECEPTOR; EPIGALLOCATECHIN GALLATE; MICRORNA 21;

EID: 79954572581     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.10-167924     Document Type: Article
Times cited : (208)

References (57)
  • 3
    • 33846603663 scopus 로고    scopus 로고
    • Androgen receptor coregulators and their involvement in the development and progression of prostate cancer
    • DOI 10.1002/ijc.22365
    • Chmelar, R., Buchanan, G., Need, E. F., Tilley, W., and Greenberg, N. M. (2007) Androgen receptor coregulators and their involvement in the development and progression of prostate cancer. Int. J. Cancer 120, 719-733 (Pubitemid 46175390)
    • (2007) International Journal of Cancer , vol.120 , Issue.4 , pp. 719-733
    • Chmelar, R.1    Buchanan, G.2    Need, E.F.3    Tilley, W.4    Greenberg, N.M.5
  • 4
    • 0026587321 scopus 로고
    • Nuclear localization of androgen receptor in heterogeneous samples of normal, hyperplastic and neoplastic human prostate
    • Chodak, G. W., Kranc, D. M., Puy, L. A., Takeda, H., Johnson, K., and Chang, C. (1992) Nuclear localization of androgen receptor in heterogeneous samples of normal, hyperplastic and neoplastic human prostate. J. Urol. 147, 798-803
    • (1992) J. Urol. , vol.147 , pp. 798-803
    • Chodak, G.W.1    Kranc, D.M.2    Puy, L.A.3    Takeda, H.4    Johnson, K.5    Chang, C.6
  • 7
    • 14944364652 scopus 로고    scopus 로고
    • Androgen receptor levels in prostate cancer epithelial and peritumoral stromal cells identify non-organ confined disease
    • DOI 10.1002/pros.20154
    • Ricciardelli, C., Choong, C. S., Buchanan, G., Vivekanandan, S., Neufing, P., Stahl, J., Marshall, V. R., Horsfall, D. J., and Tilley, W. D. (2005) Androgen receptor levels in prostate cancer epithelial and peritumoral stromal cells identify non-organ confined disease. Prostate 63, 19-28 (Pubitemid 40365387)
    • (2005) Prostate , vol.63 , Issue.1 , pp. 19-28
    • Ricciardelli, C.1    Choong, C.S.2    Buchanan, G.3    Vivekanandan, S.4    Neufing, P.5    Stahl, J.6    Marshall, V.R.7    Horsfall, D.J.8    Tilley, W.D.9
  • 9
    • 0029684751 scopus 로고    scopus 로고
    • Androgen regulation of gene expression
    • Perry, J. E., Grossmann, M. E., and Tindall, D. J. (1996) Androgen regulation of gene expression. Prostate Suppl. 6, 79-81 (Pubitemid 26112293)
    • (1996) Prostate , vol.28 , Issue.3 SUPPL. 6 , pp. 79-81
    • Perry, J.E.1    Grossmann, M.E.2    Tindall, D.J.3
  • 10
    • 0026536710 scopus 로고
    • Tissue-specific and hormonal regulation of human prostate-specific glandular kallikrein
    • Young, C. Y., Andrews, P. E., Montgomery, B. T., and Tindall, D. J. (1992) Tissue-specific and hormonal regulation of human prostate-specific glandular kallikrein. Biochemistry 31, 818-824
    • (1992) Biochemistry , vol.31 , pp. 818-824
    • Young, C.Y.1    Andrews, P.E.2    Montgomery, B.T.3    Tindall, D.J.4
  • 11
    • 0034612780 scopus 로고    scopus 로고
    • Apoptosis: Translating theory to therapy for prostate cancer
    • Isaacs, J. T. (2000) Apoptosis: translating theory to therapy for prostate cancer. J. Natl. Cancer Inst. 92, 1367-1369
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 1367-1369
    • Isaacs, J.T.1
  • 12
    • 0032230278 scopus 로고    scopus 로고
    • Catalytic cleavage of the androgen receptor messenger RNA and functional inhibition of androgen receptor activity by a hammerhead ribozyme
    • Chen, S., Song, C. S., Lavrovsky, Y., Bi, B., Vellanoweth, R., Chatterjee, B., and Roy, A. K. (1998) Catalytic cleavage of the androgen receptor messenger RNA and functional inhibition of androgen receptor activity by a hammerhead ribozyme. Mol. Endocrinol. 12, 1558-1566 (Pubitemid 30663438)
    • (1998) Molecular Endocrinology , vol.12 , Issue.10 , pp. 1558-1566
    • Chen, S.1    Song, C.S.2    Lavrovsky, Y.3    Bi, B.4    Vellanoweth, R.5    Chatterjee, B.6    Roy, A.K.7
  • 13
    • 23144434218 scopus 로고    scopus 로고
    • Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells
    • DOI 10.1016/j.jsbmb.2005.04.029, PII S0960076005002037
    • Haag, P., Bektic, J., Bartsch, G., Klocker, H., and Eder, I. E. (2005) Androgen receptor down regulation by small interference RNA induces cell growth inhibition in androgen sensitive as well as in androgen independent prostate cancer cells. J. Steroid Biochem. Mol. Biol. 96, 251-258 (Pubitemid 41080506)
    • (2005) Journal of Steroid Biochemistry and Molecular Biology , vol.96 , Issue.3-4 , pp. 251-258
    • Haag, P.1    Bektic, J.2    Bartsch, G.3    Klocker, H.4    Eder, I.E.5
  • 14
    • 18044362777 scopus 로고    scopus 로고
    • Small-interfering RNA-induced androgen receptor silencing leads to apoptotic cell death in prostate cancer
    • DOI 10.1158/1535-7163.MCT-04-0313
    • Liao, X., Tang, S., Thrasher, J. B., Griebling, T. L., and Li, B. (2005) Small-interfering RNA-induced androgen receptor silencing leads to apoptotic cell death in prostate cancer. Mol. Cancer Ther. 4, 505-515 (Pubitemid 40601831)
    • (2005) Molecular Cancer Therapeutics , vol.4 , Issue.4 , pp. 505-515
    • Liao, X.1    Tang, S.2    Thrasher, J.B.3    Griebling, T.L.4    Li, B.5
  • 15
    • 68049116232 scopus 로고    scopus 로고
    • Tea polyphenols decrease serum levels of prostate-specific antigen, hepatocyte growth factor, and vascular endothelial growth factor in prostate cancer patients and inhibit production of hepatocyte growth factor and vascular endothelial growth factor in vitro
    • McLarty, J., Bigelow, R. L., Smith, M., Elmajian, D., Ankem, M., and Cardelli, J. A. (2009) Tea polyphenols decrease serum levels of prostate-specific antigen, hepatocyte growth factor, and vascular endothelial growth factor in prostate cancer patients and inhibit production of hepatocyte growth factor and vascular endothelial growth factor in vitro. Cancer Prev. Res. (Phila.) 2, 673-682
    • (2009) Cancer Prev. Res. (Phila.) , vol.2 , pp. 673-682
    • McLarty, J.1    Bigelow, R.L.2    Smith, M.3    Elmajian, D.4    Ankem, M.5    Cardelli, J.A.6
  • 16
    • 31544473720 scopus 로고    scopus 로고
    • Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: A preliminary report from a one-year proof-of-principle study
    • DOI 10.1158/0008-5472.CAN-05-1145
    • Bettuzzi, S., Brausi, M., Rizzi, F., Castagnetti, G., Peracchia, G., and Corti, A. (2006) Chemoprevention of human prostate cancer by oral administration of green tea catechins in volunteers with high-grade prostate intraepithelial neoplasia: a preliminary report from a one-year proof-of-principle study. Cancer Res. 66, 1234-1240 (Pubitemid 43165995)
    • (2006) Cancer Research , vol.66 , Issue.2 , pp. 1234-1240
    • Bettuzzi, S.1    Brausi, M.2    Rizzi, F.3    Castagnetti, G.4    Peracchia, G.5    Corti, A.6
  • 17
    • 33947404063 scopus 로고    scopus 로고
    • Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo
    • DOI 10.1158/1078-0432.CCR-06-2269
    • Adhami, V. M., Malik, A., Zaman, N., Sarfaraz, S., Siddiqui, I. A., Syed, D. N., Afaq, F., Pasha, F. S., Saleem, M., and Mukhtar, H. (2007) Combined inhibitory effects of green tea polyphenols and selective cyclooxygenase-2 inhibitors on the growth of human prostate cancer cells both in vitro and in vivo. Clin. Cancer Res. 13, 1611-1619 (Pubitemid 46450454)
    • (2007) Clinical Cancer Research , vol.13 , Issue.5 , pp. 1611-1619
    • Adhami, V.M.1    Malik, A.2    Zaman, N.3    Sarfaraz, S.4    Siddiqui, I.A.5    Syed, D.N.6    Afaq, F.7    Pasha, F.S.8    Saleem, M.9    Mukhtar, H.10
  • 19
    • 58549106545 scopus 로고    scopus 로고
    • Suppression of androgen receptor signaling and prostate specific antigen expression by (-)-epigallocatechin-3-gallate in different progression stages of LNCaP prostate cancer cells
    • Chuu, C. P., Chen, R. Y., Kokontis, J. M., Hiipakka, R. A., and Liao, S. (2009) Suppression of androgen receptor signaling and prostate specific antigen expression by (-)-epigallocatechin-3-gallate in different progression stages of LNCaP prostate cancer cells. Cancer Lett. 275, 86-92
    • (2009) Cancer Lett. , vol.275 , pp. 86-92
    • Chuu, C.P.1    Chen, R.Y.2    Kokontis, J.M.3    Hiipakka, R.A.4    Liao, S.5
  • 20
    • 34250821024 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate and bicalutamide cause growth arrest and apoptosis in NRP-152 and NRP-154 prostate epithelial cells
    • DOI 10.1111/j.1442-2042.2007.01774.x
    • Morrissey, C., Brown, M., O'Sullivan, J., Weathered, N., Watson, R. W., and Tenniswood, M. (2007) Epigallocatechin-3-gallate and bicalutamide cause growth arrest and apoptosis in NRP-152 and NRP-154 prostate epithelial cells. Int. J. Urol. 14, 545-551 (Pubitemid 46985545)
    • (2007) International Journal of Urology , vol.14 , Issue.6 , pp. 545-551
    • Morrissey, C.1    Brown, M.2    O'Sullivan, J.3    Weathered, N.4    Watson, R.W.G.5    Tenniswood, M.6
  • 21
    • 0142153877 scopus 로고    scopus 로고
    • Interactions of androgens, green tea catechins and the antiandrogen flutamide with the external glucose-binding site of the human erythrocyte glucose transporter GLUT1
    • DOI 10.1038/sj.bjp.0705460
    • Naftalin, R. J., Afzal, I., Cunningham, P., Halai, M., Ross, C., Salleh, N., and Milligan, S. R. (2003) Interactions of androgens, green tea catechins and the antiandrogen flutamide with the external glucose-binding site of the human erythrocyte glucose transporter GLUT1. Br. J. Pharmacol. 140, 487-499 (Pubitemid 37330493)
    • (2003) British Journal of Pharmacology , vol.140 , Issue.3 , pp. 487-499
    • Naftalin, R.J.1    Afzal, I.2    Cunningham, P.3    Halai, M.4    Ross, C.5    Salleh, N.6    Milligan, S.R.7
  • 22
    • 0034611606 scopus 로고    scopus 로고
    • Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells
    • Ren, F., Zhang, S., Mitchell, S. H., Butler, R., and Young, C. Y. (2000) Tea polyphenols down-regulate the expression of the androgen receptor in LNCaP prostate cancer cells. Oncogene 19, 1924-1932 (Pubitemid 30219035)
    • (2000) Oncogene , vol.19 , Issue.15 , pp. 1924-1932
    • Ren, F.1    Zhang, S.2    Mitchell, S.H.3    Butler, R.4    Young, C.Y.F.5
  • 23
    • 41149143243 scopus 로고    scopus 로고
    • Green tea polyphenol EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis
    • DOI 10.1038/sj.onc.1210840, PII 1210840
    • Siddiqui, I. A., Malik, A., Adhami, V. M., Asim, M., Hafeez, B. B., Sarfaraz, S., and Mukhtar, H. (2008) Green tea polyphenol EGCG sensitizes human prostate carcinoma LNCaP cells to TRAIL-mediated apoptosis and synergistically inhibits biomarkers associated with angiogenesis and metastasis. Oncogene 27, 2055-2063 (Pubitemid 351442738)
    • (2008) Oncogene , vol.27 , Issue.14 , pp. 2055-2063
    • Siddiqui, I.A.1    Malik, A.2    Adhami, V.M.3    Asim, M.4    Hafeez, B.B.5    Sarfaraz, S.6    Mukhtar, H.7
  • 24
    • 44849102368 scopus 로고    scopus 로고
    • Src kinase potentiates androgen receptor transactivation function and invasion of androgen-independent prostate cancer C4-2 cells
    • DOI 10.1038/sj.onc.1211016, PII 1211016
    • Asim, M., Siddiqui, I. A., Hafeez, B. B., Baniahmad, A., and Mukhtar, H. (2008) Src kinase potentiates androgen receptor transactivation function and invasion of androgen-independent prostate cancer C4-2 cells. Oncogene 27, 3596-3604 (Pubitemid 351793796)
    • (2008) Oncogene , vol.27 , Issue.25 , pp. 3596-3604
    • Asim, M.1    Siddiqui, I.A.2    Hafeez, B.B.3    Baniahmad, A.4    Mukhtar, H.5
  • 25
    • 33846347711 scopus 로고    scopus 로고
    • The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay
    • DOI 10.1021/bi061321b
    • Ozers, M. S., Marks, B. D., Gowda, K., Kupcho, K. R., Ervin, K. M., De Rosier, T., Qadir, N., Eliason, H. C., Riddle, S. M., and Shekhani, M. S. (2007) The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay. Biochemistry 46, 683-695 (Pubitemid 46133586)
    • (2007) Biochemistry , vol.46 , Issue.3 , pp. 683-695
    • Ozers, M.S.1    Marks, B.D.2    Gowda, K.3    Kupcho, K.R.4    Ervin, K.M.5    De Rosier, T.6    Qadir, N.7    Eliason, H.C.8    Riddle, S.M.9    Shekhani, M.S.10
  • 26
    • 49549110281 scopus 로고    scopus 로고
    • Suppression of NFkappaB and its regulated gene products by oral administration of green tea polyphenols in an autochthonous mouse prostate cancer model
    • Siddiqui, I. A., Shukla, Y., Adhami, V. M., Sarfaraz, S., Asim, M., Hafeez, B. B., and Mukhtar, H. (2008) Suppression of NFkappaB and its regulated gene products by oral administration of green tea polyphenols in an autochthonous mouse prostate cancer model. Pharm. Res. 25, 2135-2142
    • (2008) Pharm. Res. , vol.25 , pp. 2135-2142
    • Siddiqui, I.A.1    Shukla, Y.2    Adhami, V.M.3    Sarfaraz, S.4    Asim, M.5    Hafeez, B.B.6    Mukhtar, H.7
  • 27
    • 35648970526 scopus 로고    scopus 로고
    • Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12
    • DOI 10.1074/jbc.M705524200
    • Cantin, L., Faucher, F., Couture, J. F., de Jesus-Tran, K. P., Legrand, P., Ciobanu, L. C., Frechette, Y., Labrecque, R., Singh, S. M., Labrie, F., and Breton, R. (2007) Structural characterization of the human androgen receptor ligand-binding domain complexed with EM5744, a rationally designed steroidal ligand bearing a bulky chain directed toward helix 12. J. Biol. Chem. 282, 30910-30919 (Pubitemid 350035181)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.42 , pp. 30910-30919
    • Cantin, L.1    Faucher, F.R.2    Couture, J.-F.3    De Jesus-Tran, K.P.4    Legrand, P.5    Ciobanu, L.C.6    Frechette, Y.7    Labrecque, R.8    Singh, S.M.9    Labrie, F.10    Breton, R.11
  • 28
    • 0043067996 scopus 로고    scopus 로고
    • Role of p53 and NF-κB in epigallocatechin-3-gallate-induced apoptosis of LNCaP cells
    • DOI 10.1038/sj.onc.1206708
    • Hastak, K., Gupta, S., Ahmad, N., Agarwal, M. K., Agarwal, M. L., and Mukhtar, H. (2003) Role of p53 and NF-kappaB in epigallocatechin-3-gallate- induced apoptosis of LNCaP cells. Oncogene 22, 4851-4859 (Pubitemid 36981273)
    • (2003) Oncogene , vol.22 , Issue.31 , pp. 4851-4859
    • Hastak, K.1    Gupta, S.2    Ahmad, N.3    Agarwal, M.K.4    Agarwal, M.L.5    Mukhtar, H.6
  • 30
    • 0027161982 scopus 로고
    • 2-terminal and steroid-binding domains
    • Wong, C. I., Zhou, Z. X., Sar, M., and Wilson, E. M. (1993) Steroid requirement for androgen receptor dimerization and DNA binding. Modulation by intramolecular interactions between the NH2-terminal and steroid-binding domains. J. Biol. Chem. 268, 19004-19012 (Pubitemid 23273853)
    • (1993) Journal of Biological Chemistry , vol.268 , Issue.25 , pp. 19004-19012
    • Wong, C.-I.1    Zhou, Z.-X.2    Sar, M.3    Wilson, E.M.4
  • 31
    • 0028809317 scopus 로고
    • Specificity of ligand-dependent androgen receptor stabilization: Receptor domain interactions influence ligand dissociation and receptor stability
    • Zhou, Z. X., Lane, M. V., Kemppainen, J. A., French, F. S., and Wilson, E. M. (1995) Specificity of ligand-dependent androgen receptor stabilization: receptor domain interactions influence ligand dissociation and receptor stability. Mol. Endocrinol. 9, 208-218
    • (1995) Mol. Endocrinol. , vol.9 , pp. 208-218
    • Zhou, Z.X.1    Lane, M.V.2    Kemppainen, J.A.3    French, F.S.4    Wilson, E.M.5
  • 32
    • 54249097888 scopus 로고    scopus 로고
    • A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice
    • Khan, N., Asim, M., Afaq, F., Abu Zaid, M., and Mukhtar, H. (2008) A novel dietary flavonoid fisetin inhibits androgen receptor signaling and tumor growth in athymic nude mice. Cancer Res. 68, 8555-8563
    • (2008) Cancer Res. , vol.68 , pp. 8555-8563
    • Khan, N.1    Asim, M.2    Afaq, F.3    Abu Zaid, M.4    Mukhtar, H.5
  • 35
    • 0033152164 scopus 로고    scopus 로고
    • Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist
    • Taplin, M. E., Bubley, G. J., Ko, Y. J., Small, E. J., Upton, M., Rajeshkumar, B., and Balk, S. P. (1999) Selection for androgen receptor mutations in prostate cancers treated with androgen antagonist. Cancer Res. 59, 12511-2515
    • (1999) Cancer Res. , vol.59 , pp. 12511-12515
    • Taplin, M.E.1    Bubley, G.J.2    Ko, Y.J.3    Small, E.J.4    Upton, M.5    Rajeshkumar, B.6    Balk, S.P.7
  • 36
    • 48549089747 scopus 로고    scopus 로고
    • Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance
    • Dehm, S. M., Schmidt, L. J., Heemers, H. V., Vessella, R. L., and Tindall, D. J. (2008) Splicing of a novel androgen receptor exon generates a constitutively active androgen receptor that mediates prostate cancer therapy resistance. Cancer Res. 68, 5469-5477
    • (2008) Cancer Res. , vol.68 , pp. 5469-5477
    • Dehm, S.M.1    Schmidt, L.J.2    Heemers, H.V.3    Vessella, R.L.4    Tindall, D.J.5
  • 37
    • 55049086227 scopus 로고    scopus 로고
    • The contribution of different androgen receptor domains to receptor dimerization and signaling
    • Centenera, M. M., Harris, J. M., Tilley, W. D., and Butler, L. M. (2008) The contribution of different androgen receptor domains to receptor dimerization and signaling. Mol. Endocrinol. 22, 2373-2382
    • (2008) Mol. Endocrinol. , vol.22 , pp. 2373-2382
    • Centenera, M.M.1    Harris, J.M.2    Tilley, W.D.3    Butler, L.M.4
  • 38
    • 0141676097 scopus 로고    scopus 로고
    • Endocrine mechanisms of disease: Expression and degradation of androgen receptor: Mechanism and clinical implication
    • DOI 10.1210/jc.2003-030261
    • Lee, D. K., and Chang, C. (2003) Endocrine mechanisms of disease: Expression and degradation of androgen receptor: mechanism and clinical implication. J. Clin. Endocrinol. Metab. 88, 4043-4054 (Pubitemid 37153696)
    • (2003) Journal of Clinical Endocrinology and Metabolism , vol.88 , Issue.9 , pp. 4043-4054
    • Lee, D.K.1    Chang, C.2
  • 40
    • 40749090479 scopus 로고    scopus 로고
    • Widespread deregulation of microRNA expression in human prostate cancer
    • DOI 10.1038/sj.onc.1210809, PII 1210809
    • Ozen, M., Creighton, C. J., Ozdemir, M., and Ittmann, M. (2008) Widespread deregulation of microRNA expression in human prostate cancer. Oncogene 27, 1788-1793 (Pubitemid 351380263)
    • (2008) Oncogene , vol.27 , Issue.12 , pp. 1788-1793
    • Ozen, M.1    Creighton, C.J.2    Ozdemir, M.3    Ittmann, M.4
  • 43
    • 70349459742 scopus 로고    scopus 로고
    • MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation
    • Lee, K. H., Chen, Y. L., Yeh, S. D., Hsiao, M., Lin, J. T., Goan, Y. G., and Lu, P. J. (2009) MicroRNA-330 acts as tumor suppressor and induces apoptosis of prostate cancer cells through E2F1-mediated suppression of Akt phosphorylation. Oncogene 28, 3360-3370
    • (2009) Oncogene , vol.28 , pp. 3360-3370
    • Lee, K.H.1    Chen, Y.L.2    Yeh, S.D.3    Hsiao, M.4    Lin, J.T.5    Goan, Y.G.6    Lu, P.J.7
  • 44
    • 77949982878 scopus 로고    scopus 로고
    • Treatment of castration-resistant prostate cancer: Updates on therapeutics targeting the androgen receptor signaling pathway
    • Zhu, W., Zhu, D. S., Madan, R. A., Gulley, J. L., Figg, W. D., and Dahut, W. L. (2009) Treatment of castration-resistant prostate cancer: updates on therapeutics targeting the androgen receptor signaling pathway. Am. J. Ther. 17, 176-181.
    • (2009) Am. J. Ther. , vol.17 , pp. 176-181
    • Zhu, W.1    Zhu, D.S.2    Madan, R.A.3    Gulley, J.L.4    Figg, W.D.5    Dahut, W.L.6
  • 45
    • 51449087794 scopus 로고    scopus 로고
    • Targeting the androgen receptor pathway in prostate cancer
    • Chen, Y., Sawyers, C. L., and Scher, H. I. (2008) Targeting the androgen receptor pathway in prostate cancer. Curr. Opin. Pharmacol. 8, 440-448
    • (2008) Curr. Opin. Pharmacol. , vol.8 , pp. 440-448
    • Chen, Y.1    Sawyers, C.L.2    Scher, H.I.3
  • 46
    • 0041337028 scopus 로고    scopus 로고
    • Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells
    • DOI 10.1002/ijc.11317
    • Brusselmans, K., De Schrijver, E., Heyns, W., Verhoeven, G., and Swinnen, J. V. (2003) Epigallocatechin-3-gallate is a potent natural inhibitor of fatty acid synthase in intact cells and selectively induces apoptosis in prostate cancer cells. Int. J. Cancer 106, 856-862 (Pubitemid 37071663)
    • (2003) International Journal of Cancer , vol.106 , Issue.6 , pp. 856-862
    • Brusselmans, K.1    De Schrijver, E.2    Heyns, W.3    Verhoeven, G.4    Swinnen, J.V.5
  • 47
    • 33751106423 scopus 로고    scopus 로고
    • Role of epigallocatechin gallate (EGCG) in the treatment of breast and prostate cancer
    • DOI 10.1016/j.lfs.2006.07.036, PII S0024320506006114
    • Stuart, E. C., Scandlyn, M. J., and Rosengren, R. J. (2006) Role of epigallocatechin gallate (EGCG) in the treatment of breast and prostate cancer. Life Sci. 79, 2329-2336 (Pubitemid 44772933)
    • (2006) Life Sciences , vol.79 , Issue.25 , pp. 2329-2336
    • Stuart, E.C.1    Scandlyn, M.J.2    Rosengren, R.J.3
  • 49
    • 0028844189 scopus 로고
    • Selective inhibition of steroid 5 alpha-reductase isozymes by tea epicatechin-3-gallate and epigallocatechin-3-gallate
    • Liao, S., and Hiipakka, R. A. (1995) Selective inhibition of steroid 5 alpha-reductase isozymes by tea epicatechin-3-gallate and epigallocatechin-3- gallate. Biochem. Biophys. Res. Commun. 214, 833-838
    • (1995) Biochem. Biophys. Res. Commun. , vol.214 , pp. 833-838
    • Liao, S.1    Hiipakka, R.A.2
  • 50
    • 0032516721 scopus 로고    scopus 로고
    • Induction of apoptosis in prostate cancer cell lines by the green tea component, (-)-epigallocatechin-3-gallate
    • DOI 10.1016/S0304-3835(98)00084-6, PII S0304383598000846
    • Paschka, A. G., Butler, R., and Young, C. Y. (1998) Induction of apoptosis in prostate cancer cell lines by the green tea component, (-)-epigallocatechin-3-gallate. Cancer Lett. 130, 1-7 (Pubitemid 28425331)
    • (1998) Cancer Letters , vol.130 , Issue.1-2 , pp. 1-7
    • Paschka, A.G.1    Butler, R.2    Young, C.Y.-F.3
  • 51
    • 0031444312 scopus 로고    scopus 로고
    • Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells
    • Ahmad, N., Feyes, D. K., Nieminen, A. L., Agarwal, R., and Mukhtar, H. (1997) Green tea constituent epigallocatechin-3-gallate and induction of apoptosis and cell cycle arrest in human carcinoma cells. J. Natl. Cancer Inst. 89, 1881-1886 (Pubitemid 28009824)
    • (1997) Journal of the National Cancer Institute , vol.89 , Issue.24 , pp. 1881-1886
    • Ahmad, N.1    Feyes, D.K.2    Nieminen, A.-L.3    Agarwal, R.4    Mukhtar, H.5
  • 52
    • 0033135024 scopus 로고    scopus 로고
    • Prostate cancer chemoprevention by green tea: In vitro and in vivo inhibition of testosterone-mediated induction of ornithine decarboxylase
    • Gupta, S., Ahmad, N., Mohan, R. R., Husain, M. M., and Mukhtar, H. (1999) Prostate cancer chemoprevention by green tea: in vitro and in vivo inhibition of testosterone-mediated induction of ornithine decarboxylase. Cancer Res. 59, 2115-2120 (Pubitemid 29217674)
    • (1999) Cancer Research , vol.59 , Issue.9 , pp. 2115-2120
    • Gupta, S.1    Ahmad, N.2    Mohan, R.R.3    Husain, M.M.4    Mukhtar, H.5
  • 53
    • 0034177207 scopus 로고    scopus 로고
    • Growth inhibition, cell-cycle dysregulation, and induction of apoptosis by green tea constituent (-)-epigallocatechin-3-gallate in androgen-sensitive and androgen-insensitive human prostate carcinoma cells
    • DOI 10.1006/taap.1999.8885
    • Gupta, S., Ahmad, N., Nieminen, A. L., and Mukhtar, H. (2000) Growth inhibition, cell-cycle dysregulation, and induction of apoptosis by green tea constituent (-)-epigallocatechin-3-gallate in androgen-sensitive and androgen-insensitive human prostate carcinoma cells. Toxicol. Appl. Pharmacol. 164, 82-90 (Pubitemid 30198547)
    • (2000) Toxicology and Applied Pharmacology , vol.164 , Issue.1 , pp. 82-90
    • Gupta, S.1    Ahmad, N.2    Nieminen, A.-L.3    Mukhtar, H.4
  • 54
    • 0037135630 scopus 로고    scopus 로고
    • Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor
    • DOI 10.1074/jbc.M203310200
    • Masiello, D., Cheng, S., Bubley, G. J., Lu, M. L., and Balk, S. P. (2002) Bicalutamide functions as an androgen receptor antagonist by assembly of a transcriptionally inactive receptor. J. Biol. Chem. 277, 26321-26326 (Pubitemid 34967123)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.29 , pp. 26321-26326
    • Masiello, D.1    Cheng, S.2    Bubley, G.J.3    Lu, M.L.4    Balk, S.P.5
  • 56
    • 0033022342 scopus 로고    scopus 로고
    • A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase
    • DOI 10.1038/6495
    • Craft, N., Shostak, Y., Carey, M., and Sawyers, C. L. (1999) A mechanism for hormone-independent prostate cancer through modulation of androgen receptor signaling by the HER-2/neu tyrosine kinase. Nat. Med. 5, 280-285 (Pubitemid 29124362)
    • (1999) Nature Medicine , vol.5 , Issue.3 , pp. 280-285
    • Craft, N.1    Shostak, Y.2    Carey, M.3    Sawyers, C.L.4
  • 57
    • 20444479428 scopus 로고    scopus 로고
    • c-Myc-regulated microRNAs modulate E2F1 expression
    • DOI 10.1038/nature03677
    • O'Donnell, K. A., Wentzel, E. A., Zeller, K. I., Dang, C. V., and Mendell, J. T. (2005) c-Myc-regulated microRNAs modulate E2F1 expression. Nature 435, 839-843 (Pubitemid 40839736)
    • (2005) Nature , vol.435 , Issue.7043 , pp. 839-843
    • O'Donnell, K.A.1    Wentzel, E.A.2    Zeller, K.I.3    Dang, C.V.4    Mendell, J.T.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.