2-Cyano-3,10-dioxooleana-1,9(11)-dien-28-oic acid anhydride. A novel and highly potent anti-inflammatory and cytoprotective agent

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 7, 2010, Pages 2275-2278

  Honda, Tadashi ^a   Padegimas, Eric M ^a   David, Emilie ^a   Sundararajan, Chitra ^a   Liby, Karen T ^b   Williams, Charlotte ^b   Sporn, Michael B ^b   Visnick, Melean ^c  

^a Dartmouth College   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

^c Reata Pharmaceuticals Inc   (United States)

Author keywords

Acid anhydride; Inducers of heme oxygenase 1; Inhibitors of nitric oxide production; Oleanolic acid; Triterpene

Indexed keywords

2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID; 2 CYANO 3,12 DIOXOOLEANA 1,9 DIEN 28 OIC ACID ANHYDRIDE; ACID ANHYDRIDE; ANTIINFLAMMATORY AGENT; CARBOXYL GROUP; NITRIC OXIDE; TRITERPENOID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CELL PROTECTION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG POTENCY; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MOUSE; NONHUMAN; SYNTHESIS; TISSUE;

ANHYDRIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS; CELL LINE, TUMOR; CYTOPROTECTION; HEME OXYGENASE-1; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; OLEANOLIC ACID; TRITERPENES;

EID: 77949488635     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.02.007     Document Type: Article

References (11)

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4. In preliminary stages, we used ip injection instead of po administration because CDDO anhydride 1 is deemed to be readily converted to CDDO in the stomach. In advanced stages, we will use duodenum injection and/or we will administer 1 as an entric coated pill.
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9. 2.
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