Synthesis and biological evaluation of fatty acyl ester derivatives of (-)-2′,3′-dideoxy-3′-thiacytidine

Journal of Medicinal Chemistry

Volumn 55, Issue 10, 2012, Pages 4861-4871

  Agarwal, Hitesh K ^a   Chhikara, Bhupender S ^a   Hanley, Michael J ^a   Ye, Guofeng ^a   Doncel, Gustavo F ^b   Parang, Keykavous ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

^b EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5' O (12 THIOETHYLDODECANOYL) 2',3' DIDEOXY 3' THIACYTIDINE; 5' O 12 AZIDODODECANOYL DERIVATIVE; ANTIVIRUS AGENT; LAMIVUDINE; MYRISTOYL; N4 (12 AZIDODODECANOYL) 2',3' DIDEOXY 3' THIACYTIDINE; N4 (12 THIOETHYLDODECANOYL) 2',3' DIDEOXY 3' THIACYTIDINE; N4 (TETRADECANOYL) 2',3' DIDEOXY 3' THIACYTIDINE; N4,5' (DITETRADECANOYL) 2',3' DIDEOXY 3' THIACYTIDINE; N4,5' DI(12 AZIDODODECANOYL) 2',3' DIDEOXY 3' THIACYTIDINE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROLYSIS; INCUBATION TIME; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS ISOLATION; WILD TYPE;

ANTI-HIV AGENTS; AZIDES; CELL LINE; CELL SURVIVAL; CYTIDINE; DRUG RESISTANCE, MULTIPLE, VIRAL; ESTERS; FATTY ACIDS; HIV-1; HUMANS; HYDROLYSIS; LAMIVUDINE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861494284     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm300492q     Document Type: Article

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