Synthesis and biological evaluation of fatty acyl ester derivatives of 2′,3′-didehydro-2′,3′-dideoxythymidine

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 7, 2011, Pages 1917-1921

  Agarwal, Hitesh K ^a   Loethan, Kelly ^a   Mandal, Deendayal ^a   Doncel, Gustavo F ^b   Parang, Keykavous ^a  

^a UNIVERSITY OF RHODE ISLAND   (United States)

^b EASTERN VIRGINIA MEDICAL SCHOOL   (United States)

Author keywords

2 ,3 Didehydro 2 ,3 dideoxythymidine; Anti HIV; Cellular uptake; Fatty acids; Stavudine

Indexed keywords

5' O (FATTY ACYL) ESTER DERIVATIVE; 5' O 12 AMINODODECANOYL DERIVATIVE; 5' O 12 AZIDODODECANOYL DERIVATIVE; 5' O 12 BROMODODECANOYL DERIVATIVE; 5' O 12 THIOETHYLDODECANOYL DERIVATIVE; BETA ALANINE; FATTY ACID DERIVATIVE; MYRISTIC ACID; STAVUDINE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL TRANSPORT; CONCENTRATION RESPONSE; CYTOTOXICITY TEST; DRUG CONJUGATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROLYSIS; LIPOPHILICITY; MYRISTYLATION;

ANTI-HIV AGENTS; CELL LINE; CELL-FREE SYSTEM; ESTERS; HUMANS; MICROSCOPY, FLUORESCENCE; STAVUDINE;

EID: 79952487359     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.02.070     Document Type: Article

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