Polybiguanides, particularly polyethylene hexamethylene biguanide, have activity against human immunodeficiency virus type 1

Biomedicine and Pharmacotherapy

Volumn 59, Issue 8, 2005, Pages 438-445

  Krebs, Fred C ^a   Miller, Shendra R ^a   Ferguson, Mary Lee ^a   Labib, Mohamed ^b   Rando, Robert F ^b   Wigdahl, Brian ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b Novaflux Biosciences Inc   (United States)

Author keywords

HIV 1; Microbicide; Polybiguanide

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BIGUANIDE DERIVATIVE; DEXTRAN SULFATE; HYDROCARBON; NONOXINOL 9; POLY(HEXAMETHYLENEBIGUANIDE); POLYETHYLENE BIGUANIDE; POLYETHYLENE HEXAMETHYLENE BIGUANIDE; POLYTETRAMETHYLENE BIGUANIDE; SPERMICIDAL AGENT; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; ARTICLE; CELL FREE SYSTEM; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; FEMALE; HELA CELL; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IN VITRO STUDY; PRIORITY JOURNAL; UTERINE CERVIX EPITHELIUM; VAGINA EPITHELIUM; VIRUS INHIBITION;

ANTI-HIV AGENTS; ANTI-INFECTIVE AGENTS; BIGUANIDES; CELL SURVIVAL; DEXTRAN SULFATE; DOSE-RESPONSE RELATIONSHIP, DRUG; HELA CELLS; HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; NONOXYNOL; SPERMATOCIDAL AGENTS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRUS REPLICATION;

EID: 25644439332     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopha.2005.07.007     Document Type: Article

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