Potential role of p38-mitogene-activated protein kinase and nuclear factor-kappa B expression in testicular dysfunction associated with varicocele: An experimental study

Andrologia

Volumn 44, Issue SUPPL.1, 2012, Pages 94-101

  Simsek, A ^a   Ozbek, E ^a   Ilbey, Y O ^a   Cekmen, M ^b   Somay, A ^a   Tasci, A I ^c  

^a Bezm i Alem Valide Sultan Vakif Gureba Research and Education Hospital   (Turkey)

^b KOCAELI UNIVERSITY   (Turkey)

^c Bakirkoy Research and Education Hospital   (Turkey)

Author keywords

INOS; MAPK; NF kB; Oxidative stress; Rat; Testis; Varicocele

Indexed keywords

GLUTATHIONE; INDUCIBLE NITRIC OXIDE SYNTHASE; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE P38; NITRIC OXIDE; TRANSCRIPTION FACTOR RELA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; INTRACELLULAR SIGNALING; LIPID OXIDATION; MALE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; SEMINIFEROUS TUBULE; SERTOLI CELL; SHAM PROCEDURE; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOGONIUM; TESTICULAR DYSFUNCTION; TESTIS; TESTIS DISEASE; VARICOCELE;

ANIMALS; GLUTATHIONE; IMMUNOHISTOCHEMISTRY; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; NF-KAPPA B; NITRIC OXIDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, WISTAR; SPERMATOGENESIS; TESTIS; VARICOCELE;

EID: 84861482745     PISSN: 03034569     EISSN: 14390272     Source Type: Journal    
DOI: 10.1111/j.1439-0272.2010.01145.x     Document Type: Article

References (40)

1. Adams JM, Cory S (1998) The Bcl-2 protein family: arbiters of cell survival. Science281:1322-1326.
2. Agarwal A, Sharma RK, Desai NR, Prabakaran S, Tavares A, Sabanegh E (2009) Role of oxidative stress in pathogenesis of varicocele and infertility. Urology73:461-469.
3. Ateşşahin A, Karahan I, Türk G, Gür S, Yilmaz S, Ceribasi AO (2006) Protective role of lycopene on cisplatin-induced changes in sperm characteristics, testicular damage and oxidative stress in rats. Reprod Toxicol21:42-47.
4. Caprio M, Isidori AM, Carta AR, Moretti C, Dufau ML, Fabbri A (1999) Expression of functional leptin receptors in rodent Leydig cells. Endocrinology140:4939-4947.
5. Chatterjee PK, Brown PA, Cuzzocrea S, Zacharowski K, Stewart KN, Mota-Filipe H (2001) Calpain inhibitor-1 reduces renal ischemia/reperfusion injury in the rat. Kidney Int59:2073-2083.
6. Davis KL, Martin E, Turko IV, Murad F (2001) Novel effects of nitric oxide. Annu Rev Pharmacol Toxicol41:203-236.
7. El-Hefnawy T, Ioffe S, Dym M (2000) Expression of the leptin receptor during germ cell development in the mouse testis. Endocrinology141:2624-2630.
8. Fretz PC, Sandlow JI (2002) Varicocele: current concepts in pathophysiology, diagnosis, and treatment. Urol Clin North Am29:921-937.
9. Goligorsky MS, Brodsky SV, Noiri E (2002) Nitric oxide in acute renal failure: NOS versus NOS. Kidney Int61:855-861.
10. Granger DL, Taintor RR, Boockvar KS, Hibbs JB Jr (1999) Measurement of nitrate and nitrite in biological samples using nitrate reductase and Griess reaction. Methods Enzymol268:142-151.
11. Gutiérrez-Venegas G, Maldonado-Frías S, Ontiveros-Granados A, Kawasaki-Cárdenas P (2005) Role of p38 in nitric oxide synthase and cyclooxygenase expression, and nitric oxide and PGE2 synthesis in human gingival fibroblasts stimulated with lipopolysaccharides. Life Sci77:60-73.
12. Hassan A, El-Nashar EM, Mostafa T (2009) Programmed cell death in varicocele-bearing testes. Andrologia41:39-45.
13. Herlaar E, Brown Z (1999) p38 MAPK signalling cascades in inflammatory disease. Mol Med Today5:439-447.
14. Ilbey YO, Ozbek E, Cekmen M, Simsek A, Otunctemur A, Somay A (2009) Protective effect of curcumin in cisplatin-induced oxidative injury in rat testis: mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways. Hum Reprod24:1717-1725.
15. Ishikawa T, Fujioka H, Ishimura T, Takenaka A, Fujisawa M (2007) Expression of leptin and leptin receptor in the testis of fertile and infertile patients. Andrologia39:22-27.
16. Izu H, Inouye S, Fujimoto M, Shiraishi K, Naito K, Nakai A (2004) Heat shock transcription factor 1 is involved in quality-control mechanisms in male germ cells. Biol Reprod70:18-24.
17. Jang J, Park EY, Seo SI, Hwang TK, Kim JC (2006) Effects of intravesical instillation of cyclooxygenase-2 inhibitor on the expression of inducible nitric oxide synthase and nerve growth factor in cyclophosphamide-induced overactive bladder. BJU Int98:435-439.
18. Jiang F, Roberts SJ, Datla S, Dusting GJ (2006) NO modulates NADPH oxidase function via heme oxygenase-1 in human endothelial cells. Hypertension48:950-957.
19. Johnsen L, Petty CS, Neaves WB (1980) Relationship of biopsy evalution and testicular measurement to over-all daily sperm production in human testis. Fertil Steril34:36-40.
20. Kisa U, Başar MM, Ferhat M, Yilmaz E, Başar H, Caǧlayan O, Batislam E (2004) Testicular tissue nitric oxide and thiobarbituric acid reactive substance levels: evaluation with respect to the pathogenesis of varicocele. Urol Res32:196-199.
21. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem193:265-275.
22. Mitropoulos D, Deliconstantinos G, Zervas A, Villiotou V, Dimopoulos C, Stavrides J (1996) Nitric oxide synthase and xanthine oxidase activities in the spermatic vein of patients with varicocele: a potential role for nitric oxide and peroxynitrite in sperm dysfunction. J Urol156:1952-1958.
23. Moochhala S, Chhatwal VJ, Chan ST, Ngoi SS, Chia YW, Rauff A (1996) Nitric oxide synthase activity and expression in human colorectal cancer. Carcinogenesis17:1171-1174.
24. Moron MS, Depierre JW, Mannervik B (1979) Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim Biophys Acta582:67-78.
25. Notebaert S, Carlsen H, Janssen D, Vandenabeele P, Blomhoff R, Meyer E (2008) In vivo imaging of NF-kappaB activity during Escherichia coli-induced mammary gland infection. Cell Microbiol10:1249-1258.
26. O'Bryan MK, Schlatt S, Gerdprasert O, Phillips DJ, de Kretser DM, Hedger MP (2000) Inducible nitric oxide synthase in the rat testis: evidence for potential roles in both normal function and inflammation-mediated infertility. Biol Reprod63:1285-1293.
27. Ozbek E, Turkoz Y, Gokdeniz R, Davarci M, Ozugurlu F (2000) Increased nitric oxide production in the spermatic vein of patients with varicocele. Eur Urol37:172-175.
28. Pourazar J, Blomberg A, Kelly FJ, Davies DE, Wilson SJ, Holgate ST (2008) Diesel exhaust increases EGFR and phosphorylated C-terminal Tyr 1173 in the bronchial epithelium. Part Fibre Toxicol5:1-8.
29. Romeo C, Ientile R, Impellizzeri P, Turiaco N, Teletta M, Antonuccio P (2003) Preliminary report on nitric oxide-mediated oxidative damage in adolescent varicocele. Hum Reprod18:26-29.
30. Santoro G, Romeo C (2001) Normal and varicocele testis in adolescents. Asian J Androl3:259-262.
31. Santoro G, Romeo C, Impellizzeri P, Ientile R, Cutroneo G, Trimarchi F, Pedale S, Turiaco N, Gentile C (2001) Nitric oxide synthase patterns in normal and varicocele testis in adolescents. BJU Int88:967-973.
32. Sinke AP, Jayakumar AR, Panickar KS, Moriyama M, Reddy PV, Norenberg MD (2008) NFkappaB in the mechanism of ammonia-induced astrocyte swelling in culture. J Neurochem106:2302-2311.
33. Smith R, Kaune H, Parodi D, Madariaga M, Rios R, Morales I, Ríos R, Castro A (2006) Increased sperm DNA damage in patients with varicocele: relationship with seminal oxidative stress. Hum Reprod21:986-993.
34. Tek M, Cayan S, Yilmaz N, Oǧuz I, Erdem E, Akbay E (2009) The effect of vascular endothelial growth factor on spermatogenesis and apoptosis in experimentally varicocele-induced adolescent rats. Fertil Steril91:2247-2252.
35. Türker Köksal I, Erdoǧru T, Gülkesen H, Sezer C, Usta M, Ciftçioǧlu A, Baykara M (2004) The potential role of inducible nitric oxide synthase (iNOS) activity in the testicular dysfunction associated with varicocele: an experimental study. Int Urol Nephrol36:67-72.
36. Turner TT (2001) The study of varicocele through the use of animal models. Hum Reprod Update7:78-84.
37. Wasowicz W, Neve J, Peretz A (1993) Optimized steps in fluorometric determination of thiobarbituric acid reactive substances in serum: importance of extraction pH and influence of sample preservation and storage. Clin Chem39:2522-2528.
38. Xie QW, Kashiwabara Y, Nathan C (1994) Role of transcription factor NF-kappa B/Rel in induction of nitric oxide synthase. J Biol Chem269:4705-4708.
39. Yin Y, DeWolf WC, Morgentaler A (1998) Experimental cryptorchidism induces testicular germ cell apoptosis by p53-dependent and -independent pathways in mice. Biol Reprod58:492-496.
40. Yu TW, Anderson D (1997) Reactive oxygen species-induced DNA damage and its modification: a chemical investigation. Mutat Res379:201-210.