4′-Fluorinated carbocyclic nucleosides: Synthesis and inhibitory activity against S-adenosyl-l-homocysteine hydrolase

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 16, 2006, Pages 5578-5583

  Kitade, Yukio ^a   Ando, Takayuki ^a   Yamaguchi, Tsuyoshi ^a   Hori, Ayumi ^a   Nakanishi, Masayuki ^a   Ueno, Yoshihito ^a  

^a GIFU UNIVERSITY   (Japan)

Author keywords

Carbocyclic nucleoside; Enzyme inhibitor; Fluoro carbocyclic nucleoside

Indexed keywords

9 (2',3' DIHYDROXY 4' FLUOROCYCLOPENTAN 1' YL) 9H 2 AMINOADENINE; 9 (2',3' DIHYDROXY 4' FLUOROCYCLOPENTAN 1' YL) 9H ADENINE; ADENOSYLHOMOCYSTEINASE; CARBOCYCLIC NUCLEOSIDE; DIETHYLAMINOSULFUR TRIFLUORIDE; FLUORIDE; PALLADIUM; UNCLASSIFIED DRUG; ADENOSINE; ANTIVIRUS AGENT; CYCLOPENTANE DERIVATIVE; DRUG DERIVATIVE; NUCLEOSIDE; S ADENOSYLHOMOCYSTEINE;

ARTICLE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; FLUORINATION; PLASMODIUM FALCIPARUM; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; ANIMAL; CHEMICAL MODEL; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; SYNTHESIS;

PLASMODIUM FALCIPARUM;

ADENOSINE; ADENOSYLHOMOCYSTEINASE; ANIMALS; ANTIVIRAL AGENTS; CYCLOPENTANES; HUMANS; MODELS, CHEMICAL; NUCLEOSIDES; PLASMODIUM FALCIPARUM; S-ADENOSYLHOMOCYSTEINE;

EID: 33745620458     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.04.023     Document Type: Article

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