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Volumn 7, Issue 5, 2012, Pages

Down-regulation of GEP100 causes increase in E-cadherin levels and inhibits pancreatic cancer cell invasion

Author keywords

[No Author keywords available]

Indexed keywords

GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANINE NUCLEOTIDE EXCHANGE PROTEIN 100; MATRIGEL; MESSENGER RNA; PUROMYCIN; UNCLASSIFIED DRUG; UVOMORULIN;

EID: 84861476919     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037854     Document Type: Article
Times cited : (19)

References (39)
  • 1
    • 77950635816 scopus 로고    scopus 로고
    • Pancreatic cancer: pathobiology, treatment options, and drug delivery
    • Li J, Wientjes MG, Au JL, (2010) Pancreatic cancer: pathobiology, treatment options, and drug delivery. AAPS J 12: 223-232.
    • (2010) AAPS J , vol.12 , pp. 223-232
    • Li, J.1    Wientjes, M.G.2    Au, J.L.3
  • 5
    • 52149123619 scopus 로고    scopus 로고
    • Core signaling pathways in human pancreatic cancers revealed by global genomic analyses
    • Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, et al. (2008) Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 321: 1801-1806.
    • (2008) Science , vol.321 , pp. 1801-1806
    • Jones, S.1    Zhang, X.2    Parsons, D.W.3    Lin, J.C.4    Leary, R.J.5
  • 6
    • 67650924582 scopus 로고    scopus 로고
    • Pancreatic cancer: molecular pathogenesis and new therapeutic Targets
    • Wong HH, Lemoine NR, (2009) Pancreatic cancer: molecular pathogenesis and new therapeutic Targets. Nat Rev Gastroenterol Hepatol 6: 412-422.
    • (2009) Nat Rev Gastroenterol Hepatol , vol.6 , pp. 412-422
    • Wong, H.H.1    Lemoine, N.R.2
  • 8
    • 0141426586 scopus 로고    scopus 로고
    • Control of myoblast fusion by a guanine nucleotide exchange factor, loner, and its effector ARF6
    • Chen EH, Pryce BA, Tzeng JA, Gonzalez GA, Olson EN, (2003) Control of myoblast fusion by a guanine nucleotide exchange factor, loner, and its effector ARF6. Cell 114: 751-762.
    • (2003) Cell , vol.114 , pp. 751-762
    • Chen, E.H.1    Pryce, B.A.2    Tzeng, J.A.3    Gonzalez, G.A.4    Olson, E.N.5
  • 9
    • 31944442964 scopus 로고    scopus 로고
    • The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins
    • Dunphy JL, Moravec R, Ly K, Lasell TK, Melancon P, et al. (2006) The Arf6 GEF GEP100/BRAG2 regulates cell adhesion by controlling endocytosis of beta1 integrins. Curr Biol 16: 315-320.
    • (2006) Curr Biol , vol.16 , pp. 315-320
    • Dunphy, J.L.1    Moravec, R.2    Ly, K.3    Lasell, T.K.4    Melancon, P.5
  • 10
    • 33746097786 scopus 로고    scopus 로고
    • GEP100/BRAG2: activator of ADP-ribosylation factor 6 for regulation of cell adhesion and actin cytoskeleton via E-cadherin and alpha-catenin
    • Hiroi T, Someya A, Thompson W, Moss J, Vaughan M, (2006) GEP100/BRAG2: activator of ADP-ribosylation factor 6 for regulation of cell adhesion and actin cytoskeleton via E-cadherin and alpha-catenin. Proc Natl Acad Sci U S A 103: 10672-10677.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 10672-10677
    • Hiroi, T.1    Someya, A.2    Thompson, W.3    Moss, J.4    Vaughan, M.5
  • 11
    • 40849119785 scopus 로고    scopus 로고
    • Myoblasts and macrophages share molecular components that contribute to cell-cell fusion
    • Pajcini KV, Pomerantz JH, Alkan O, Doyonnas R, Blau HM, (2008) Myoblasts and macrophages share molecular components that contribute to cell-cell fusion. Cell Biol 180: 1005-1019.
    • (2008) Cell Biol , vol.180 , pp. 1005-1019
    • Pajcini, K.V.1    Pomerantz, J.H.2    Alkan, O.3    Doyonnas, R.4    Blau, H.M.5
  • 12
    • 33751552743 scopus 로고    scopus 로고
    • Involvement of a guanine nucleotide-exchange protein, ARF-GEP100/BRAG2a, in the apoptotic cell death of monocytic phagocytes
    • Someya A, Moss J, Nagaoka I, (2006) Involvement of a guanine nucleotide-exchange protein, ARF-GEP100/BRAG2a, in the apoptotic cell death of monocytic phagocytes. J Leukoc Biol 80: 915-921.
    • (2006) J Leukoc Biol , vol.80 , pp. 915-921
    • Someya, A.1    Moss, J.2    Nagaoka, I.3
  • 13
    • 34249078574 scopus 로고    scopus 로고
    • Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2
    • Dunphy JL, Ye K, Casanova JE, (2007) Nuclear functions of the Arf guanine nucleotide exchange factor BRAG2. Traffic 8: 661-672.
    • (2007) Traffic , vol.8 , pp. 661-672
    • Dunphy, J.L.1    Ye, K.2    Casanova, J.E.3
  • 14
    • 77957252297 scopus 로고    scopus 로고
    • The guanine nucleotide exchange protein for ADP-ribosylation factor 6, ARF-GEP100/BRAG2, regulates phagocytosis of monocytic phagocytes in an ARF6-dependent process
    • Someya A, Moss J, Nagaoka I, (2010) The guanine nucleotide exchange protein for ADP-ribosylation factor 6, ARF-GEP100/BRAG2, regulates phagocytosis of monocytic phagocytes in an ARF6-dependent process. J Biol Chem 285 (40): 30698-30707.
    • (2010) J Biol Chem , vol.285 , Issue.40 , pp. 30698-30707
    • Someya, A.1    Moss, J.2    Nagaoka, I.3
  • 15
    • 80051698338 scopus 로고    scopus 로고
    • GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis
    • Hashimoto A, Hashimoto S, Ando R, Noda K, Ogawa E, et al. (2011) GEP100-Arf6-AMAP1-cortactin pathway frequently used in cancer invasion is activated by VEGFR2 to promote angiogenesis. PLoS One 6: e23359.
    • (2011) PLoS One , vol.6
    • Hashimoto, A.1    Hashimoto, S.2    Ando, R.3    Noda, K.4    Ogawa, E.5
  • 16
    • 37749041462 scopus 로고    scopus 로고
    • GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion
    • Morishige M, Hashimoto S, Ogawa E, Toda Y, Kotani H, et al. (2008) GEP100 links epidermal growth factor receptor signalling to Arf6 activation to induce breast cancer invasion. Nat Cell Biol 10: 85-92.
    • (2008) Nat Cell Biol , vol.10 , pp. 85-92
    • Morishige, M.1    Hashimoto, S.2    Ogawa, E.3    Toda, Y.4    Kotani, H.5
  • 17
    • 80053089901 scopus 로고    scopus 로고
    • Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma
    • Menju T, Hashimoto S, Hashimoto A, Otsuka Y, Handa H, et al. (2011) Engagement of overexpressed Her2 with GEP100 induces autonomous invasive activities and provides a biomarker for metastases of lung adenocarcinoma. PLoS One 6: e25301.
    • (2011) PLoS One , vol.6
    • Menju, T.1    Hashimoto, S.2    Hashimoto, A.3    Otsuka, Y.4    Handa, H.5
  • 19
    • 0032510494 scopus 로고    scopus 로고
    • A causal role for E-cadherin in the transition from adenoma to carcinoma
    • Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G, (1998) A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392: 190-193.
    • (1998) Nature , vol.392 , pp. 190-193
    • Perl, A.K.1    Wilgenbus, P.2    Dahl, U.3    Semb, H.4    Christofori, G.5
  • 20
    • 0032410023 scopus 로고    scopus 로고
    • Aberrant E-cadherin expression associated with loss of differentiation and advanced stage in human pancreatic cancer
    • Karayiannakis AJ, Syrigos KN, Chatzigianni E, Papanikolaou S, Alexiou D, et al. (1998) Aberrant E-cadherin expression associated with loss of differentiation and advanced stage in human pancreatic cancer. Anticancer Res 18: 4177-4180.
    • (1998) Anticancer Res , vol.18 , pp. 4177-4180
    • Karayiannakis, A.J.1    Syrigos, K.N.2    Chatzigianni, E.3    Papanikolaou, S.4    Alexiou, D.5
  • 21
    • 0034151860 scopus 로고    scopus 로고
    • Down-regulation of E-cadherin by antisense oligonucleotide enhances basement membrane invasion of pancreatic carcinoma cells
    • Takao S, Che X, Fukudome T, Natsugoe S, Ozawa M, et al. (2000) Down-regulation of E-cadherin by antisense oligonucleotide enhances basement membrane invasion of pancreatic carcinoma cells. Hum Cell 13: 15-21.
    • (2000) Hum Cell , vol.13 , pp. 15-21
    • Takao, S.1    Che, X.2    Fukudome, T.3    Natsugoe, S.4    Ozawa, M.5
  • 22
    • 80052413002 scopus 로고    scopus 로고
    • Loss of E-cadherin expression and outcome among patientswith resectable pancreatic adenocarcinomas
    • Hong SM, Li A, Olino K, Wolfgang CL, Herman JM, et al. (2011) Loss of E-cadherin expression and outcome among patientswith resectable pancreatic adenocarcinomas. Mod Pathol 24: 1237-1247.
    • (2011) Mod Pathol , vol.24 , pp. 1237-1247
    • Hong, S.M.1    Li, A.2    Olino, K.3    Wolfgang, C.L.4    Herman, J.M.5
  • 23
    • 79956044903 scopus 로고    scopus 로고
    • Tissue Biomarkers for Prognosis in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-analysis
    • Jamieson NB, Carter CR, McKay CJ, Oien KA, (2011) Tissue Biomarkers for Prognosis in Pancreatic Ductal Adenocarcinoma: A Systematic Review and Meta-analysis. Clin Cancer Res 17: 3316-3331.
    • (2011) Clin Cancer Res , vol.17 , pp. 3316-3331
    • Jamieson, N.B.1    Carter, C.R.2    McKay, C.J.3    Oien, K.A.4
  • 24
    • 0031766695 scopus 로고    scopus 로고
    • Inhibition of liver metastasis of human pancreatic carcinoma by angiogenesis inhibitor TNP-470 in combination with cisplatin
    • Shishido T, Yasoshima T, Denno R, Mukaiya M, Sato N, et al. (1998) Inhibition of liver metastasis of human pancreatic carcinoma by angiogenesis inhibitor TNP-470 in combination with cisplatin. Jpn J Cancer Res 89: 963-969.
    • (1998) Jpn J Cancer Res , vol.89 , pp. 963-969
    • Shishido, T.1    Yasoshima, T.2    Denno, R.3    Mukaiya, M.4    Sato, N.5
  • 25
    • 0034060279 scopus 로고    scopus 로고
    • Effect of matrix metalloproteinase inhibition on pancreatic cancer invasion and metastasis: an additive strategy for cancer control
    • Jimenez RE, Hartwig W, Antoniu BA, Compton CC, Warshaw AL, et al. (2000) Effect of matrix metalloproteinase inhibition on pancreatic cancer invasion and metastasis: an additive strategy for cancer control. Ann Surg 231: 644-654.
    • (2000) Ann Surg , vol.231 , pp. 644-654
    • Jimenez, R.E.1    Hartwig, W.2    Antoniu, B.A.3    Compton, C.C.4    Warshaw, A.L.5
  • 26
    • 67650999217 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer
    • Arumugam T, Ramachandran V, Fournier KF, Wang H, Marquis L, et al. (2009) Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer. Cancer Res 69: 5820-5828.
    • (2009) Cancer Res , vol.69 , pp. 5820-5828
    • Arumugam, T.1    Ramachandran, V.2    Fournier, K.F.3    Wang, H.4    Marquis, L.5
  • 28
    • 35348884249 scopus 로고    scopus 로고
    • Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors
    • Casanova JE, (2007) Regulation of Arf activation: the Sec7 family of guanine nucleotide exchange factors. Traffic 8: 1476-1485.
    • (2007) Traffic , vol.8 , pp. 1476-1485
    • Casanova, J.E.1
  • 30
    • 65549123466 scopus 로고    scopus 로고
    • Molecular mechanisms controlling E-cadherin expression in breast cancer
    • Baranwal S, Alahari SK, (2009) Molecular mechanisms controlling E-cadherin expression in breast cancer. Biochem Biophys Res Commun 384: 6-11.
    • (2009) Biochem Biophys Res Commun , vol.384 , pp. 6-11
    • Baranwal, S.1    Alahari, S.K.2
  • 31
    • 59849124834 scopus 로고    scopus 로고
    • Regulation of cadherin trafficking
    • Delva E, Kowalczyk AP, (2009) Regulation of cadherin trafficking. Traffic 10: 259-267.
    • (2009) Traffic , vol.10 , pp. 259-267
    • Delva, E.1    Kowalczyk, A.P.2
  • 32
    • 0028318730 scopus 로고
    • Control of cell behavior during vertebrate development by Slug, a zinc finger gene
    • Nieto MA, Sargent MG, Wilkinson DG, Cooke J, (1994) Control of cell behavior during vertebrate development by Slug, a zinc finger gene. Science 264: 835-839.
    • (1994) Science , vol.264 , pp. 835-839
    • Nieto, M.A.1    Sargent, M.G.2    Wilkinson, D.G.3    Cooke, J.4
  • 33
    • 0036513626 scopus 로고    scopus 로고
    • The snail superfamily of zinc-finger transcription factors
    • Nieto MA, (2002) The snail superfamily of zinc-finger transcription factors. Nat Rev Mol Cell Biol 3: 155-166.
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 155-166
    • Nieto, M.A.1
  • 34
    • 0037326569 scopus 로고    scopus 로고
    • The transcription factor Slug represses E-cadherin expression and induces epithelial tomesenchymal transitions: a comparison with Snail and E47repressors
    • Bolós V, Peinado H, Pérez-Moreno MA, Fraga MF, Esteller M, et al. (2003) The transcription factor Slug represses E-cadherin expression and induces epithelial tomesenchymal transitions: a comparison with Snail and E47repressors. J Cell Sci 116: 499-511.
    • (2003) J Cell Sci , vol.116 , pp. 499-511
    • Bolós, V.1    Peinado, H.2    Pérez-Moreno, M.A.3    Fraga, M.F.4    Esteller, M.5
  • 35
    • 63849130585 scopus 로고    scopus 로고
    • Role of the epithelial-mesenchymal transition regulator Slug in primary human cancers
    • Alves CC, Carneiro F, Hoefler H, Becker KF, (2009) Role of the epithelial-mesenchymal transition regulator Slug in primary human cancers. Front Biosci 14: 3035-3050.
    • (2009) Front Biosci , vol.14 , pp. 3035-3050
    • Alves, C.C.1    Carneiro, F.2    Hoefler, H.3    Becker, K.F.4
  • 36
    • 34548078651 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition: expression of the regulators snail, slug, and twist in pancreatic cancer
    • Hotz B, Arndt M, Dullat S, Bhargava S, Buhr HJ, et al. (2007) Epithelial to mesenchymal transition: expression of the regulators snail, slug, and twist in pancreatic cancer. Clin Cancer Res 13: 4769-4776.
    • (2007) Clin Cancer Res , vol.13 , pp. 4769-4776
    • Hotz, B.1    Arndt, M.2    Dullat, S.3    Bhargava, S.4    Buhr, H.J.5
  • 37
    • 77954333340 scopus 로고    scopus 로고
    • Cadherin-mediated intercellular adhesion and signaling cascades involving small GTPases
    • Watanabe T, Sato K, Kaibuchi K, (2009) Cadherin-mediated intercellular adhesion and signaling cascades involving small GTPases. Cold Spring Harb Perspect Biol 1: a003020.
    • (2009) Cold Spring Harb Perspect Biol , vol.1
    • Watanabe, T.1    Sato, K.2    Kaibuchi, K.3
  • 38
    • 63849164451 scopus 로고    scopus 로고
    • Regulation of epithelial junctions by proteins of the ADP-ribosylation factor family
    • Hiroi T, (2009) Regulation of epithelial junctions by proteins of the ADP-ribosylation factor family. Front Biosci 14: 717-730.
    • (2009) Front Biosci , vol.14 , pp. 717-730
    • Hiroi, T.1
  • 39
    • 0035801516 scopus 로고    scopus 로고
    • An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration
    • Palacios F, Price L, Schweitzer J, Collard JG, D'Souza-Schorey C, (2001) An essential role for ARF6-regulated membrane traffic in adherens junction turnover and epithelial cell migration. EMBO J 20: 4973-4986.
    • (2001) EMBO J , vol.20 , pp. 4973-4986
    • Palacios, F.1    Price, L.2    Schweitzer, J.3    Collard, J.G.4    D'Souza-Schorey, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.