Effects of lactose-β-sitosterol and β-sitosterol on ovalbumin-induced lung inflammation in actively sensitized mice

International Immunopharmacology

Volumn 7, Issue 12, 2007, Pages 1517-1527

  Yuk, Ji Eun ^a   Woo, Jin Suk ^b   Yun, Chi Young ^c   Lee, Ji Sook ^c   Kim, Joo Hwan ^c   Song, Gyu Yong ^d   Yang, Eun Ju ^a   Hur, In Kang ^b   Kim, In Sik ^a  

^a Eulji University   (South Korea)

^b GeneChem Inc   (South Korea)

^c Daejeon University   (South Korea)

^d Chungnam National University   (South Korea)

Author keywords

sitosterol; Asthma; Lactose sitosterol

Indexed keywords

ALCIAN BLUE; DEXAMETHASONE; IMMUNOGLOBULIN E; INTERLEUKIN 4; INTERLEUKIN 5; LACTOSE BETA SITOSTEROL; OVALBUMIN; REACTIVE OXYGEN METABOLITE; SITOGLUSIDE; SITOSTEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTHMA; CELL INFILTRATION; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HISTOPATHOLOGY; HYPERPLASIA; LUNG LAVAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY TRACT INFLAMMATION; SENSITIZATION;

ANIMALS; ANTI-ASTHMATIC AGENTS; ASTHMA; BRONCHOALVEOLAR LAVAGE FLUID; CELL SURVIVAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EOSINOPHILS; FEMALE; GENE EXPRESSION; GLYCOSIDES; IMMUNOGLOBULIN E; INTERLEUKIN-13; INTERLEUKIN-4; INTERLEUKIN-5; LACTOSE; LEUKOCYTES; LUNG; MICE; MICE, INBRED BALB C; MOLECULAR STRUCTURE; OVALBUMIN; PNEUMONIA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SITOSTEROLS; VACCINATION;

EID: 34848843013     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2007.07.026     Document Type: Article

References (25)

1. Djukanovic R., Roche W.R., Wilson J.W., Beasley C.R., Twentyman O.P., Howarth R.H., et al. Mucosal inflammation in asthma. Am Rev Respir Dis 142 (1990) 434-457
2. Kay A.B. Allergy and allergic diseases, first of two parts. N Engl J Med 344 (2001) 30-37
3. Elsner J., and Kapp A. Regulation and modulation of eosinophil effector functions. Allergy 54 (1999) 15-26
4. Martin B.L., Caruna-Montaldo B., and Craig T. Comprehensive management of asthma. Drugs Today 33 (1997) 149-160
5. Pegel K.H. The importance of sitosterol and sitosterolin in human and animal nutrition. SA J Sci 93 (1997) 263-268
6. Bouic P.J., Etsebeth S., Liebenberg R.W., Albrecht C.F., Pegel K., and Van Jaarsveld P.P. Beta-Sitosterol and beta-sitosterol glucoside stimulate human peripheral blood lymphocyte proliferation: implications for their use as an immunomodulatory vitamin combination. Int J Immunopharmacol 18 (1996) 693-700
7. Fernandez M.L., and Vega-Lopez S. Efficacy and safety of sitosterol in the management of blood cholesterol levels. Cardiovasc Drug Rev 23 (2005) 57-70
8. Gupta M.B., Nath R., Srivastava N., Shanker K., Kishor K., and Bhargava K.P. Anti-inflammatory and antipyretic activities of β-sitosterol. Planta Med 39 (1980) 157-163
9. Ivorra M.D., D'Ocon M.P., Paya M., and Villar A. Antihyperglycemic and insulin releasing effects of β-sitosterol 3-β-d-glycoside and its aglycone β-sitosterol. Arch Int Pharmacodyn Ther 296 (1988) 224-231
10. Bouic P.J., and Lamprecht J.H. Plant sterols and sterolins: a review of their immune-modulating properties. Altern Med Rev 4 (1999) 170-177
11. Duan W., Chan J.H., Wong C.H., Leung B.P., and Wong W.S. Antiinflammatory effects of mitogen-activated protein kinase inhibitor U0126 in an asthma mouse model. J Immunol 172 (2004) 7053-7059
12. Kuperman D.A., Huang X.L., Koth L., Chang G.H., Dolganov G.M., Zhu Z., et al. Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 8 (2002) 885-889
13. Henricks P.A., and Nijkamp F.P. Reactive oxygen species as mediators in asthma. Pulm Pharmacol Ther 14 (2001) 409-420
14. National Institutes of Health. Global Initiative for Asthma: pocket guide for asthma management and prevention. Publication vol. 02-3659 (2002)
15. Barnes P.J., Chung K.F., and Page C.P. Inflammatory mediators of asthma: an update. Pharmacol Rev 50 4 (1998) 515-596
16. Kips J.C. Cytokines in asthma. Eur Respir J Suppl 34 (2001) 24-33
17. Corry D.B., Folkesson H.G., Warnock M.L., Erle D.J., Mathay M.A., Matthay M.A., et al. Locksley, Interleukin-4, but not interleukin-5 or eosinophils, is required in a murine model of acute airway hyperresponsiveness. J Exp Med 183 (1996) 109-117
18. Renz H., Ensslek K., Lauffer L., Kurrle R., and Gelfand E.W. Inhibition of allergen-induced IgE and IgG1 production by soluble IL-4 receptor. Int Arch Allergy Immunol 106 (1995) 46-54
19. Kopf M., Brombacher F., Hodgkin P.D., Ramsay A.J., Milbourne E.A., Dai W.J., et al. IL-5-deficient mice have a developmental defect in CD5z B-1 cells and lack eosinophilia but have normal antibody and cytotoxic T cell responses. Immunity 4 (1996) 15-24
20. Foster P.S., Hogan S.P., Ramsay A.J., Matthaei K.I., and Youngt I.G. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model. Exp Med 183 1 (1996) 195-201
21. Grunig G., Warnock M., Wakil A.E., Venkayya R., Brombacher F., Rennick D.M., et al. Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282 (1998) 2261-2263
22. Owen C.E. Immunoglobulin E: Role in asthma and allergic disease: lessons from the clinic. Pharmacol Ther 113 (2007) 121-133
23. Wilson D.R., Merrett T.G., Varga E.M., Smurthwaite L., Gould H.J., Kemp M., et al. Increases in allergen-specific IgE in BAL after segmental allergen challenge in atopic asthmatics. Am J Respir Crit Care Med 165 (2002) 22-26
24. Trigg C.J., Manolitsas N.D., Wang J., Calderon M.A., McAulay A., Jordan S.E., et al. Placebo controlled immunopathologic study of four months of inhaled corticosteroids in asthma. Am J Respir Crit Care Med 150 (1994) 17-22
25. Caramori G., and Adcock I. Anti-inflammatory mechanisms of glucocorticoids targeting granulocytes. Curr Drug Targets Inflamm Allergy 4 (2005) 455-463