The COMT Val158 allele is associated with impaired delayed-match-to-sample performance in ADHD

Behavioral and Brain Functions

Volumn 8, Issue , 2012, Pages

  Matthews, Natasha ^a   Vance, Alasdair ^b   Cummins, Tarrant D R ^a   Wagner, Joseph ^a   Connolly, Amanda ^b   Yamada, Jacqueline ^b   Lockhart, Paul J ^c   Panwar, Ajay ^a   Wallace, Robyn H ^a   Bellgrove, Mark A ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b ROYAL CHILDREN'S HOSPITAL   (Australia)

^c MURDOCH CHILDREN'S RESEARCH INSTITUTE   (Australia)

Author keywords

Attention deficit hyperactivity disorder; COMT; Working memory

Indexed keywords

CATECHOL METHYLTRANSFERASE; CATECHOLAMINE; DOPAMINE BETA MONOOXYGENASE; VALINE;

ADOLESCENT; AGE; ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; DRD2 GENE; DRD4 GENE; FEMALE; GENDER; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; INTELLIGENCE QUOTIENT; MAJOR CLINICAL STUDY; MALE; NET1 GENE; PRIORITY JOURNAL; RECEPTOR GENE; TASK PERFORMANCE; WORKING MEMORY; ALLELE; GENETICS; HETEROZYGOTE; HOMOZYGOTE; NEUROPSYCHOLOGICAL TEST; PATTERN RECOGNITION; PHENOTYPE; PHYSIOLOGY; REACTION TIME; SHORT TERM MEMORY;

ADOLESCENT; ALLELES; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CATECHOL O-METHYLTRANSFERASE; CHILD; FEMALE; GENETIC VARIATION; GENOTYPE; HETEROZYGOTE; HOMOZYGOTE; HUMANS; MALE; MEMORY, SHORT-TERM; NEUROPSYCHOLOGICAL TESTS; PATTERN RECOGNITION, VISUAL; PHENOTYPE; REACTION TIME; VALINE;

EID: 84861450676     PISSN: None     EISSN: 17449081     Source Type: Journal    
DOI: 10.1186/1744-9081-8-25     Document Type: Article

References (50)

1. American Psychiatric Association Diagnostic and statistical manual of mental disorders, (4th Edn) 1994, American Psychiatric Association, Wasington DC, American Psychiatric Association.
2. Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry 2007, 164:942-948. 10.1176/appi.ajp.164.6.942, 17541055.
3. Frazier TW, Youngstrom EA, Glutting JJ, Watkins MW. ADHD and achievement: Meta-analysis of the child, adolescent, and adult literatures and a concomitant study with college students. J Learn Disabil 2007, 40:49-65. 10.1177/00222194070400010401, 17274547.
4. Faraone SV, Sergeant J, Gillberg C, Biederman J. The worldwide prevalence of ADHD: Is it an American condition?. World Psychiatry 2003, 2:104-113. 1525078, 16946912.
5. Castellanos FX, Tannock R. Neuroscience of attention-deficit/hyperactivity disorder: the search for endophenotypes. Nat Rev Neurosci 2002, 3:617-628.
6. Ando J, Ono Y, Wright MJ. Genetic structure of spatial and verbal working memory. Behav Genet 2001, 31:615-624. 10.1023/A:1013353613591, 11838538.
7. Martinussen R, Hayden J, Hogg-Johnson S, Tannock JA. A meta-analysis of working memory impairments in children with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry 2005, 44:377-384. 10.1097/01.chi.0000153228.72591.73, 15782085.
8. Baddeley A. Working memory: Looking back and looking forward. Nat Rev Neurosci 2003, 4:829-839.
9. Packiam Alloway T, Gathercole SE, Elliott J. Examining the link between working memory behaviour and academic attainment in children with ADHD. Dev Med Child Neurol 2010, 52:632-636. 10.1111/j.1469-8749.2009.03603.x, 20163434.
10. Owen AM, McMillian MK, Laird AR, Bullmore E. N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies. Hum Brain Mapp 2005, 25:46-59. 10.1002/hbm.20131, 15846822.
11. Wager TD, Smith EE. Neuroimaging studies of working memory: a meta-analysis. Cogn Affect, & Behav Neurosci 2003, 3:255-274. 10.3758/CABN.3.4.255, 21719258.
12. Curtis CE, D'Espositio M. Persistent activity in the prefrontal cortex during working memory. Trends Cogn Sci 2003, 7:415-423. 10.1016/S1364-6613(03)00197-9, 12963473.
13. Arnsten AF, Li B-M. Neurobiology of executive functions: catecholamine influences on prefrontal cortical function. Biol Psychiatry 2005, 57:1377-1384. 10.1016/j.biopsych.2004.08.019, 15950011.
14. Vijayraghavan S, Wang M, Birnbaum SG, Williams GV, Arnsten AF. Inverted-U dopamine D1 receptor actions on prefrontal neurons engaged in working memory. Nat Neurosci 2007, 10:376-384. 10.1038/nn1846, 17277774.
15. Meyer-Lindenberg A, Nichols T, Callicott JH, Ding J, Kolachana B, Buckholtz J, Mattay VS, Egan M, Weinberger DR. Impact of complex genetic variation in COMT on human brain function. Mol Psychiatry 2006, 11:867-877. 10.1038/sj.mp.4001860, 16786032.
16. Lachman HM, Papolos DF, Saito T, Yu YM, Szumlanski CL, Weinshilboum RM. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics 1996, 6:243-250. 10.1097/00008571-199606000-00007, 8807664.
17. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D, Weinberger DR. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci USA 2001, 98:6917-6922. 10.1073/pnas.111134598, 34453, 11381111.
18. Barnett JH, Jones PB, Robbins TW, Muller U. Effects of the catechol-Omethyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls. Mol Psychiatry 2007, 12:502-509.
19. Malhotra AK, Kestler LJ, Mazzanti CM, Bates JA, Goldberg TE, Goldman D. A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry 2002, 159:652-654. 10.1176/appi.ajp.159.4.652, 11925305.
20. Diamond D, Biriand L, Fosella J, Gehlbach L. Genetic and neurochemical modulation of prefrontal cognitive functions in children. Am J Psychiatry 2004, 161:125-132. 10.1176/appi.ajp.161.1.125, 14702260.
21. Cheuk D, Wong V. Meta-analysis of association between a catechol-O-methyltransferase gene polymorphism and attention deficit hyperactivity disorder. Behav Genet 2006, 36:651-659. 10.1007/s10519-006-9076-5, 16676224.
22. Tarek E, Grizenko N, Ben Amor L, Lageix P, Mbekou V, Deguzman R, Torkaman-Zehi A, Stepanian T, Baron C, Joober R. Catechol-Omethyltransferase (COMT) Val108/158Met polymorphism does not modulate executive function in children with ADHD. BMC Med Genet 2004, 5:30. 544598, 15613245.
23. Mills S, Langley K, Van Der Bree M, Street E, Turic D, Owen MJ, O'Donovan MC, Thapar A. No evidence of association between catechol-O-methyltransferase (COMT) Val158Met genotype and performance on neuropsychological tasks in children with ADHD: a case-control study. BMC Psychiatry 2004, 4:15. 10.1186/1471-244X-4-15, 425584, 15182372.
24. Bellgrove MA, Domschke K, Hawi Z, Kirley A, Mullins C, Robertson IH, Gill M. The methionine allele of the COMT polymorphism impairs prefrontal cognition in children and adolescents with ADHD. Exp Brain Res 2005, 163:352-360. 10.1007/s00221-004-2180-y, 15654584.
25. Seamans JK, Yang CR. The principal features and mechanisms of dopamine modulation in the prefrontal cortex. Prog Neurobiol 2004, 74:1-57. 10.1016/j.pneurobio.2004.05.006, 15381316.
26. Gizer IR, Ficks C, Waldman ID. Candidate gene studies of ADHD: a meta-analytic review. Hum Genet 2009, 126:51-90. 10.1007/s00439-009-0694-x, 19506906.
27. Silverman WK, Albano AM. The anxiety disorders interview schedule for children for DSM-IV (child and parent versions) 1996, Psychological Corporation, San Antonio, TX.
28. Conners CK. Conners' Rating Scales - Revised 1997, Multi-Health Systems Inc., Toronto, ON.
29. Achenbach T. Manual for the Teacher's Report Form and profile 1991, Department of Psychiatry, University of Vermont, Burlington, VT.
30. Wechsler D. Wechsler Intelligence Scale for Children-Fourth Edition. Administration and scoring manual 2003, Harcourt Assessment, Inc, San Antonio, TX.
31. Taylor E, Schachar R, Thorley G, Wieselberg M. Conduct disorder and hyperactivity: 1. separation of hyperactivity and antisocial conduct in British child psychiatric patients. Br J Psychiatry 1986, 149:760-767. 10.1192/bjp.149.6.760, 3790875.
32. Wilkinson GS. WRAT-3: Wide Range Achievement Test-3 administration manual 1993, Wide Range, Wilmington, DE.
33. Rhodes SM, Coghill DR, Matthews K. Methylphenidate restores visual memory, but not working memory function in attention deficit-hyperkinetic disorder. Psychopharmacology 2004, 175:319-330. 10.1007/s00213-004-1833-7, 15138760.
34. Need AC, Attix DK MMJ, CE T, Linney KL, Hunt P, Ge D, Heinzen EL, Maia JM, Shianna KV, et al. A Genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB battery. Hum Mol Genet 2009, 18:4650-4661. 10.1093/hmg/ddp413, 2773267, 19734545.
35. Daly G, Hawi Z, Fitzgerald M, Gill M. Mapping susceptibility loci in attention deficit hyperactivity disorder: Preferential transmission of parental alleles at DAT1, DBH and DRD5 to affected children. Mol Psychiatry 1999, 4:192-196. 10.1038/sj.mp.4000510, 10208453.
36. Bellgrove MA, Hawi Z, Gill M, Robertson IH. The cognitive genetics of attention deficit hyperactivity disorder (ADHD): Sustained attention as a candidate endophenotype. Cortex 2006, 42:838-845. 10.1016/S0010-9452(08)70426-X, 17131588.
37. Tang Y, Buxbaum SG, Waldman I, Anderson GM, Zaetian CP, Kohnke MD, Cubells JF. A single nucleotide polymorphism at DBH, possibly associated with attention-deficit/hyperactivity disorder, associates with lower plasma dopamine beta-hydroxylase activity and is in linkage disequilibrium with two putative functional single nucleotide polymorphisms. Biol Psychiatry 2006, 60:1034-1038. 10.1016/j.biopsych.2006.02.017, 16616730.
38. Kollins SH, Anastopoulos AD, Lachiewicz AM, Fitzgerald D, Morrissey-Kane E, Garrett ME, Keatts SL, Ashley-Koch AE. SNPs in dopamine D2 receptor gene (DRD2) and norepinephrine transporter gene (NET) are associated with continuous performance task (CPT) phenotypes in ADHD children and their families. Am J Med Genet B Neuropsychiatr Genet 2008, 147B(8):1580-1588. 10.1002/ajmg.b.30876, 2981338, 18821566.
39. Bellgrove MA, Hawi Z, Lowe N, Kirley A, Robertson IH, Gill M. DRD4 gene variants and sustained attention in Attention Deficit Hyperactivity Disorder (ADHD): Effects of associated alleles at the VNTR and -521 SNP. Am J Med Genet B Neuropsychiatr Genet 2005, 136(1):81-86.
40. Churchill GA, Doerge RW. Empirical threshold values for quantitative trait mapping. Genet 1994, 138:963-971.
41. Doerge RW, Churchill GA. Permutation tests for multiple loci affecting a quantitative character. Genet 1996, 142:285-294.
42. Westfall P, Young S. Resampling-Based Multiple Testing: Examples and Methods for p-value Adjustment 1993, Wiley, New York.
43. Bruder GE, Keilp JC, Xu H, Shikhman M, Schori F, Gorman JM, Gilliam TC. Catechol-O-Methyltransferase (COMT) genotypes and working memory: Associations with differing cognitive operations. Biol Psychiatry 2005, 58:901-907. 10.1016/j.biopsych.2005.05.010, 16043133.
44. Bilder RM, Volavka J, Lachman HM, Grace AA. The catechol-o-methyltransferase (COMT) polymorphism: Relations to tonic-phasic-dopamine hypothesis and neuropsychiatric phenotypes. Neuropsychopharmacology 2004, 29:1943-1961. 10.1038/sj.npp.1300542, 15305167.
45. Volkow ND, Wang G, Fowler JS, Logan J, Gerasimov M, Maynard L, Ding Y, Gatley SJ, Gifford A, Franceschi D. The therapeutic doses of oral methylphenidate significantly increases extracellular dopamine in the human brain. J Neurosci 2001, 21:RC121.
46. Coghill DR, Rhodes SM, Matthews K. The neuropsychological effects of chronic methylphenidate on drug-naive boys with attention deficit/hyperactivity disorder. Biol Psychiatry 2007, 62:954-962. 10.1016/j.biopsych.2006.12.030, 17543895.
47. Rhodes SM, Coghill DR, Matthews K. Acute neuropsychological effects of methylphenidate in stimulant drug-naive boys with ADHD II: Broader executive and non-executive domains. J Child Psychology and Psychiatry 2006, 47:1184-1194.
48. Sengupta S, Grizenko N, Schmitz N, Schwartz G, Bellingham J, Polotskaia A, Stepanian MT, Goto Y, Grace AA, Joober R. COMT Val108/158Met Polymorphism and the modulation of task-oriented behavior in children with ADHD. Neuropsychopharmacology 2008, 33:3069-3077. 10.1038/npp.2008.85, 2885152, 18580877.
49. Caspi A, Langley K, Milne B, Moffitt TE. A replicated molecular genetic basis for subtyping antisocial behavior in children with Attention-Deficit/Hyperactivity Disorder. Arch Gen Psychiatry 2008, 65(2):203-210. 10.1001/archgenpsychiatry.2007.24, 18250258.
50. Langley K, Heron J, O' Donovan MC, Owen MJ, Thapar A. Genotype link with extreme antisocial behavior: the contribution of cognitive pathways. Arch Gen Psychiatry 2010, 67(12):1317-1323. 10.1001/archgenpsychiatry.2010.163, 21135332.