Genotype link with extreme antisocial behavior: The contribution of cognitive pathways

Archives of General Psychiatry

Volumn 67, Issue 12, 2010, Pages 1317-1323

  Langley, Kate ^a   Heron, Jon ^b   O'Donovan, Michael C ^a   Owen, Michael J ^a   Thapar, Anita ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATECHOL METHYLTRANSFERASE;

ANTISOCIAL BEHAVIOR; ARTICLE; ATTENTION DEFICIT DISORDER; CHILD; COGNITION; CONDUCT DISORDER; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; GENETIC ASSOCIATION; GENETIC RISK; GENOTYPE; GENOTYPE PHENOTYPE CORRELATION; HUMAN; MAJOR CLINICAL STUDY; MALE; PROSPECTIVE STUDY; SCHOOL CHILD;

ADULT; ANTISOCIAL PERSONALITY DISORDER; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CATECHOL O-METHYLTRANSFERASE; CHILD; COGNITION; CONDUCT DISORDER; CONFIDENCE INTERVALS; DIAGNOSTIC AND STATISTICAL MANUAL OF MENTAL DISORDERS; EXECUTIVE FUNCTION; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; ODDS RATIO; PARENTS; PHENOTYPE; POLYMERASE CHAIN REACTION; PROSPECTIVE STUDIES; QUESTIONNAIRES;

EID: 78649952834     PISSN: 0003990X     EISSN: 15383636     Source Type: Journal    
DOI: 10.1001/archgenpsychiatry.2010.163     Document Type: Article

References (40)

1. Rutter M, Giller H, Hagell A. Antisocial Behavior by Young People. New York, NY: Cambridge University Press; 1998.
2. Moffitt TE. Adolescence-limited and life-course-persistent antisocial behavior: a developmental taxonomy. Psychol Rev. 1993;100(4):674-701.
3. Thapar A, Harrington R, McGuffin P. Examining the comorbidity of ADHD-related behaviours and conduct problems using a twin study design. Br J Psychiatry. 2001;179:224-229.
4. Lahey BB, Moffitt TE, Caspi A. Causes of Conduct Disorder and Juvenile Delinquency. New York, NY: Guildford Press; 2003.
5. Thapar A, Langley K, Fowler T, Rice F, Turic D, Whittinger N, Aggleton J, Van den Bree M, Owen M, O'Donovan M. Catechol O-methyltransferase gene variant and birth weight predict early-onset antisocial behavior in children with attention-deficit/ hyperactivity disorder. Arch Gen Psychiatry. 2005;62(11):1275-1278.
6. Caspi A, Langley K, Milne B, Moffitt TE, O'Donovan M, Owen MJ, Polo Tomas M, Poulton R, Rutter M, Taylor A, Williams B, Thapar A. A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/ hyperactivity disorder. Arch Gen Psychiatry. 2008;65(2):203-210.
7. Meyer-Lindenberg A, Weinberger DR. Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nat Rev Neurosci. 2006;7(10):818-827. (Pubitemid 44435264)
8. Green AE, Munafò MR, DeYoung CG, Fossella JA, Fan J, Gray JR. Using genetic data in cognitive neuroscience: from growing pains to genuine insights. Nat Rev Neurosci. 2008;9(9):710-720.
9. Walters JTR, Owen MJ. Endophenotypes in psychiatric genetics. Mol Psychiatry. 2007;12(10):886-890.
10. Rutter M. Epidemiological methods to tackle causal questions. Int J Epidemiol. 2009;38(1):3-6.
11. Bestelmeyer PE, Phillips LH, Crombie C, Benson P, St Clair D. The P300 as a possible endophenotype for schizophrenia and bipolar disorder: evidence from twin and patient studies. Psychiatry Res. 2009;169(3):212-219.
12. Durston S, de Zeeuw P, Staal WG. Imaging genetics in ADHD: a focus on cognitive control. Neurosci Biobehav Rev. 2009;33(5):674-689.
13. Patterson JV, Sandman CA, Ring A, Jin Y, Bunney WE Jr. An initial report of a new biological marker for bipolar disorder: P85 evoked brain potential. Bipolar Disord. 2009;11(6):596-609.
14. Feshbach ND. Empathy training: a field study in affective education. In: Feshbach S, Fraczek A, eds. Aggression and Behavior Change: Biological and Social Processes. New York, NY: Praeger; 1979:234-249.
15. Robinson R, Roberts WL, Strayer J, Koopman R. Empathy and emotional responsiveness in delinquent and non-delinquent adolescents. Soc Dev. 2007; 16(3):555-579. doi:10.1111/j.1467-9507.2007.00396.x.
16. Barnett JH, Heron J, Ring SM, Golding J, Goldman D, Xu K, Jones PB. Gender-specific effects of the catechol-O-methyltransferase Val108/158Met polymorphism on cognitive function in children. Am J Psychiatry. 2007;164(1):142-149.
17. Dickinson D, Elvevåg B. Genes, cognition and brain through a COMT lens. Neuroscience. 2009;164(1):72-87.
18. Egan MF, Goldberg TE, Kolachana BS, Callicott JH, Mazzanti CM, Straub RE, Goldman D,Weinberger DR. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A. 2001;98(12): 6917-6922.
19. Malhotra AK, Kestler LJ, Mazzanti C, Bates JA, Goldberg T, Goldman D. A functional polymorphism in the COMT gene and performance on a test of prefrontal cognition. Am J Psychiatry. 2002;159(4):652-654.
20. Tunbridge EM, Harrison PJ, Weinberger DR. Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond. Biol Psychiatry. 2006;60(2): 141-151.
21. Mier D, Kirsch P, Meyer-Lindenberg A. Neural substrates of pleiotropic action of genetic variation in COMT: a meta-analysis. Mol Psychiatry. 2010;15(9):918-927.
22. Diatchenko L, Slade GD, Nackley AG, Bhalang K, Sigurdsson A, Belfer I, Goldman D, Xu K, Shabalina SA, Shagin D, Max MB, Makarov SS, Maixner W. Genetic basis for individual variations in pain perception and the development of a chronic pain condition. Hum Mol Genet. 2005;14(1):135-143.
23. Fowler TA, Langley K, Rice FJ, van den Bree MB, Ross K, Wilkinson LS, Owen MJ, O'Donovan MC, Thapar A. Psychopathy trait scores in adolescents with childhood ADHD: the contribution of genotypes affecting MAOA, 5HTT and COMT activity. Psychiatr Genet. 2009;19(6):312-319.
24. Smolka MN, Schumann G, Wrase J, Grüsser SM, Flor H, Mann K, Braus DF, Goldman D, Büchel C, Heinz A. Catechol-O-methyltransferase val158met genotype affects processing of emotional stimuli in the amygdala and prefrontal cortex. J Neurosci. 2005;25(4):836-842.
25. Mechelli A, Tognin S, McGuire PK, Prata D, Sartori G, Fusar-Poli P, De Brito S, Hariri AR, Viding E. Genetic vulnerability to affective psychopathology in childhood: a combined voxel-based morphometry and functional magnetic resonance imaging study. Biol Psychiatry. 2009;66(3):231-237.
26. Golding J, Pembrey M, Jones R, Team AS; ALSPAC Study Team. ALSPAC - the Avon Longitudinal Study of Parents and Children, I: study methodology. Paediatr Perinat Epidemiol. 2001;15(1):74-87.
27. Avon Longitudinal Study of Parents and Children. University of Bristol Web site. http://www.bristol.ac.uk/alspac/sci-com/resource/data/. Accessed December 12, 2009.
28. Goodman R, Ford T, Richards H, Gatward R, Meltzer H. The Development and Well-being Assessment: description and initial validation of an integrated assessment of child and adolescent psychopathology. J Child Psychol Psychiatry. 2000;41(5):645-655.
29. Skuse D, Warrington R, Bishop D, Chowdhury U, Lau J, Mandy W, Place M. The developmental, dimensional and diagnostic interview (3di): a novel computerized assessment for autism spectrum disorders. J Am Acad Child Adolesc Psychiatry. 2004;43(5):548-558.
30. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 3rd ed, revised. Washington, DC: American Psychiatric Association; 1987.
31. Manly T, Anderson V, Nimmo-Smith I, Turner A, Watson P, Robertson IH. The differential assessment of children's attention: the Test of Everyday Attention for Children (TEA-Ch), normative sample and ADHD performance. J Child Psychol Psychiatry. 2001;42(8):1065-1081.
32. Stata Statistical Software [computer program]. Version 10. College Station, TX: StataCorp; 2007.
33. Barnett JH, Scoriels L, Munafò MR. Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism. Biol Psychiatry. 2008;64(2):137-144.
34. Jucaite A, Fernell E, Halldin C, Forssberg H, Farde L. Reduced midbrain dopamine transporter binding in male adolescents with attention-deficit/ hyperactivity disorder: association between striatal dopamine markers and motor hyperactivity. Biol Psychiatry. 2005;57(3):229-238.
35. van Haren NE, Bakker SC, Kahn RS. Genes and structural brain imaging in schizophrenia. Curr Opin Psychiatry. 2008;21(2):161-167.
36. Turic D, Williams H, Langley K, Owen M, Thapar A, O'Donovan MC. A family based study of catechol-O-methyltransferase (COMT) and attention deficit hyperactivity disorder (ADHD). Am J Med Genet B Neuropsychiatr Genet. 2005;133B (1):64-67.
37. Faraone SV, Perlis RH, Doyle AE, Smoller JW, Goralnick JJ, Holmgren MA, Sklar P. Molecular genetics of attention-deficit/hyperactivity disorder. Biol Psychiatry. 2005;57(11):1313-1323.
38. Faraone SV, Biederman J, Monuteaux MC. Toward guidelines for pedigree selection in genetic studies of attention deficit hyperactivity disorder. Genet Epidemiol. 2000;18(1):1-16. (Pubitemid 30039195)
39. Swanson J, Arnold LE, Kraemer HC, Hechtman L, Molina B, Hinshaw S, Vitiello B, Jensen P, Steinhoff K, Lerner M, Greenhill L, Abikoff H, Wells K, Epstein J, Elliott G, Newcorn J, Hoza B, Wigal T; MTA Cooperative Group. Evidence, interpretation, and qualification from multiple reports of long-term outcomes in the Multimodal Treatment Study of Children With ADHD (MTA), part I: executive summary. J Atten Disord. 2008;12(1):4-14.
40. Rutter M. Identifying the Environmental Causes of Disease: How Should We Decide What to Believe and When to Take Action? London, England: Academy of Medical Sciences; 2007.