Exploring flubendazole formulations for use in sheep. Pharmacokinetic evaluation of a cyclodextrin-based solution

BMC Veterinary Research

Volumn 8, Issue , 2012, Pages

  Ceballos, Laura ^a,b   Moreno, Laura ^a,b   Torrado, Juan J ^b,c   Lanusse, Carlos ^a,b   Alvarez, Luis ^a,b  

^a UNIVERSIDAD NACIONAL DEL CENTRO DE LA PROVINCIA DE BUENOS AIRES   (Argentina)

^b Facultad de Ciencias Naturales e Instituto M Lillo   (Argentina)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

OVIS ARIES;

ALBENDAZOLE; ANTINEMATODAL AGENT; BENZIMIDAZOLE DERIVATIVE; CYCLODEXTRIN; DRUG DERIVATIVE; FLUBENDAZOLE; MEBENDAZOLE; OXFENDAZOLE;

ANIMAL; AREA UNDER THE CURVE; ARTICLE; BLOOD; BODY FLUID; CHEMISTRY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; HALF LIFE TIME; PARASITOLOGY; RUMINANT STOMACH; SHEEP; SHEEP DISEASE; SOLUBILITY;

ABOMASUM; ALBENDAZOLE; ANIMALS; ANTINEMATODAL AGENTS; AREA UNDER CURVE; BENZIMIDAZOLES; BODY FLUIDS; CHEMISTRY, PHARMACEUTICAL; CROSS-OVER STUDIES; CYCLODEXTRINS; HALF-LIFE; MEBENDAZOLE; SHEEP; SHEEP DISEASES; SOLUBILITY;

EID: 84861447941     PISSN: None     EISSN: 17466148     Source Type: Journal    
DOI: 10.1186/1746-6148-8-71     Document Type: Article

References (37)

1. EMEA, EMEA/MRL/267/97-FINAL The European Agency for the Evaluation of Medicinal Products. Flubendazol, Summary Report 2; Veterinary Medicines Evaluation Unit 1997, London, UK: Committee for Veterinary Medicinal Products, EMEA, EMEA/MRL/267/97-FINAL.
2. Gottschall D, Theodorides V, Wang R. The metabolism of benzimidazole anthelmintics. Parasitol Today 1990, 6:115-124. 10.1016/0169-4758(90)90228-V, 15463313.
3. Maté L, Virkel G, Lifschitz A, Ballent M, Lanusse C. Hepatic and extra-hepatic metabolic pathways involved in flubendazole biotransformation in sheep. Biochem Pharmacol 2008, 76:773-783. 10.1016/j.bcp.2008.07.002, 18671949.
4. Moreno L, Alvarez L, Mottier L, Virkel G, Sanchéz Bruni S, Lanusse C. Integrated pharmacological assessment of flubendazole potential for use in sheep: disposition kinetics, liver metabolism and parasite difusión ability. J Vet Pharmacol Therap 2004, 27:299-308.
5. Lacey E. Mode of action of benzimidazoles. Parasitol Today 1990, 6:112-115. 10.1016/0169-4758(90)90227-U, 15463312.
6. Lanusse C, Prichard R. Clinical pharmacokinetics and metabolism of benzimidazole anthelmintics in ruminants. D Metab Rev 1993, 25:235-279.
7. Alvarez L, Mottier L, Lanusse C. Drug transfer into target helminth parasites. Trends Parasitol 2007, 23:97-104. 10.1016/j.pt.2007.01.003, 17236810.
8. Moreno L, Echevarria F, Muñoz F, Alvarez L, Sánchez S, Lanusse C. Dose-dependent activity of albendazole against benzimidazole-resistant nematodes in sheep: relationship between pharmacokinetics and efficacy. Exp Parasitol 2004, 106:150-157. 10.1016/j.exppara.2004.03.003, 15172222.
9. Sanchez Bruni S, Fuse L, Moreno L, Saumell C, Alvarez L, Fiel C, McKellar Q, Lanusse C. Changes to oxfendazole chiral kinetics and anthelmintic efficacy induced by piperonyl butoxide in horses. Equine Vet J 2005, 37:257-262.
10. Entrocasso C, Alvarez L, Manazza J, Lifschitz A, Borda B, Virkel G, Mottier L, Lanusse C. Clinical efficacy assessment of the albendazole-ivermectin combination in lambs parasitized with resistant nematodes. Vet Parasitol 2008, 155:249-256. 10.1016/j.vetpar.2008.04.015, 18571329.
11. Frömming K, Szejtli J. Cyclodextrins in pharmacy 1994, 27-29. Dordrecht: Kluwer Academic Publishers.
12. Loftsson T, Duchêne D. Cyclodextrins and their pharmaceutical applications. Int J Pharm 2007, 329:1-11. 10.1016/j.ijpharm.2006.10.044, 17137734.
13. Rajewski R, Stella V. Pharmaceutical applications of cyclodextrins 2. In vivo drug delivery. J Pharm Sci 1996, 85:1142-1169. 10.1021/js960075u, 8923319.
14. Diaz D, Bernad M, Gracia Mora J, Escobar Llanos C. Complexation and solubility behavior of albendazole with some cyclodextrins. Pharm Dev Technol 1998, 3:395-403. 10.3109/10837459809009867, 9742560.
15. Challa R, Ahuja A, Ali J, Khar R. Cyclodextrins in Drug Delivery: An Updated Review. AAPS PharmSciTech 2005, 6:329-357.
16. Martins P, Ochoa R, Pimenta A, Ferreira L, Melo A, Da Silva J, Sinisterra R, Demicheli C, Frezard F. Mode of action of β-cyclodextrin as an absorption enhancer of the water-soluble drug meglumine antimoniate. Int J Pharm 2006, 325:39-47. 10.1016/j.ijpharm.2006.06.014, 16876345.
17. Martinez M, Augsburgerb L, Johnstonc T, Jones W. Applying the Biopharmaceutics Classification System to veterinary pharmaceutical products. Part I: Biopharmaceutics and formulation considerations. Adv Drug Deliv Ver 2002, 54:805-824.
18. Evrard B, Chiap P, DeTullio P, Ghalmid F, Piela G, Van Heesa T, Crommen J, Losson B, Delattre L. Oral bioavailability in sheep of albendazole from a suspension and from a solution containing hydroxypropyl-β-cyclodextrin. J Control Release 2002, 85:45-50. 10.1016/S0168-3659(02)00270-5, 12480310.
19. García Rodriguez J, Torrado J, Bolas F. Improving bioavailability and anthelmintic activity of albendazole by preparing albendazole-cyclodextrin complexes. Parasite 2001, 8:188-190.
20. Casulli A, Morales M, Gallinilla B, Turchetto L, Pozio E. 2-Hydroxypropyl-beta-cyclodextrin improves the effectiveness of albendazole against encapsulated larvae of Trichinella spiralis in a murine model. J Antimicrob Chemother 2006, 58:886-890. 10.1093/jac/dkl329, 16895937.
21. Ceballos L, Elissondo M, Sánchez Bruni S, Denegri G, Alvarez L, Lanusse C. Flubendazole in cystic echinococcosis therapy: pharmaco-parasitological evaluation in mice. Parasitol Int 2009, 58:354-358. 10.1016/j.parint.2009.07.006, 19628054.
22. Jung H, Medina L, García L, Fuentes I, Moreno-Esparza R. Absorption studies of albendazole and some physicochemical properties of the drug and its metabolite albendazole sulphoxide. J Pharm Pharmacol 1997, 50:43-48.
23. Wu Z, Razzak M, Tucker I, Medlicott N. Physicochemical characterization of ricoendazole: I. Solubility, lipophilicity, and ionization characteristics. J Pharm Sci 2005, 94:983-993. 10.1002/jps.20282, 15793800.
24. Marriner S, Evans E, Bogan J. Effect of parasitism with Ostertagia circumcincta on pharmacokinetics of fenbendazole in sheep. Vet Parasitol 1985, 17:239-249. 10.1016/0304-4017(85)90036-6, 3992878.
25. McKellar Q, Scott E. The benzimidazole anthelmintic agents- a review. J Vet Pharmacol Therap 1990, 27:299-308.
26. Sánchez S, Alvarez L, Pis A, Quiroga M, Lanusse C. Differences on the plasma and abomasal disposition of albendazole and its metabolites in calves grazing on pasture or fed a concentrate diet. Res Vet Sci 1999, 66:223-230. 10.1053/rvsc.1998.0264, 10333463.
27. Petersen M, Friis C, Bjorn H. A new in vitro assay of benzimidazole activity against adult Oesophagostomum dentatum. Int J Parasitol 1997, 27:1333-1339. 10.1016/S0020-7519(97)00104-5, 9421720.
28. Alvarez L, Moreno G, Moreno L, Ceballos L, Shaw L, Fairweather I, Lanusse C. Comparative assessment of albendazole and triclabendazole ovicidal activity on Fasciola hepatica eggs. Vet Parasitol 2009, 164:211-216. 10.1016/j.vetpar.2009.05.014, 19560276.
29. Ceballos L, Alvarez L, Sanchez Bruni S, Elissondo C, Denegri G, Lanusse C. Comparative performances of flubendazole and albendazole in cystc echinococcosis. Ex vivo activity, plasma/cyst disposition, and efficacy in infected mice. Antimicrob Agents Chemother in press. Published abstract.
30. Castillo J, Palomo-Canales J, García J, Lastres J, Bolas F, Torrado J. Preparation and characterization of albendazole beta-cyclodextrin complexes. Drug Dev Ind Pharm 1999, 25:1241-1248. 10.1081/DDC-100102294, 10612019.
31. Marriner S, Bogan J. Pharmacokinetic of fenbendazole in sheep. Am J Vet Res 1981, 42:1146-1148.
32. Prichard R, Hennessy D. Effects of oesophageal groove closure on the pharmacokinetic behaviour and efficacy of oxfendazole in sheep. Res Vet Sci 1981, 30:22-27.
33. Alvarez L, Sánchez S, Lanusse C. Plasma and abomasal bioavailability of albendazole administered by different routes to sheep. J Vet Pharmacol Therap 1997, 20:70-71.
34. Komarek R. Rumen and abomasal cannulation of sheep with specially designed cannulae and a canula insertion instrument. J Anim Sci 1981, 53:791-795.
35. Lanusse C, Gascon L, Prichard R. Gastrointestinal distribution of albendazole metabolites following netobimin administration to cattle: relationship with plasma disposition kinetics. J Vet Pharmacol Therap 1993, 16:38-47.
36. Notari R. Biopharmaceutics and Clinical Pharmacokinetics 1987, 45-129. New York: Marcel Dekker.
37. Gibaldi M, Perrier D. Pharmacokinetics 1982, p45-109. New York: Marcel Dekker.