Absorption studies of albendazole and some physicochemical properties of the drug and its metabolite albendazole sulphoxide

Journal of Pharmacy and Pharmacology

Volumn 50, Issue 1, 1998, Pages 43-48

  Jung, H ^a,b   Medina, L ^b   Garcia L ^a   Fuentes, I ^a   Moreno Esparza, R ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b NATIONAL INSTITUTE OF NEUROLOGY AND NEUROSURGERY   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

ALBENDAZOLE; ALBENDAZOLE SULFOXIDE; ALBUMIN; ALPHA1 GLYCOPROTEIN; AMPHOLYTE; ANTHELMINTIC AGENT; DRUG METABOLITE; PLASMA PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; DRUG METABOLISM; DRUG PROTEIN BINDING; DRUG RELEASE; DRUG SOLUBILITY; GASTROINTESTINAL TRACT; INTESTINE ABSORPTION; INTRAGASTRIC DRUG ADMINISTRATION; IONIZATION; MALE; NONHUMAN; PH; RAT; STOMACH ABSORPTION;

EID: 0031972839     PISSN: 00223573     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-7158.1998.tb03303.x     Document Type: Article

References (15)

1. Chowan, Z. T., Amaro, A. A. (1977) Everted intestinal sacs as an in vitro model for assessing absorptivity of new drugs. J. Pharm. Sci. 66: 1249-1253
2. Charton, M. (1965a) The application of the Hammett equation to polycyclic aromatic sets. I. Quinolines and isoquinolines. J. Org. Chem. 30: 3341-3345
3. Charton, M. (1965b) Electrical effects of ortho substituents in imidazole and benzimidazoles. J. Org. Chem. 30: 3346-3350
4. De Estal, J. J., Alvarez, A. I., Villaverde, C., Prieto, G. (1993) Comparative effects of anionic, natural bile acid surfactants and mixed micelles on the intestinal absorption of the antihelmintic albendazole. Int. J. Pharm. 91: 105-109
5. Hurtado, M., Medina, M. T., Sotelo, J., Jung, H. (1989) Sensitive high-performance liquid chromatographic assay for albendazole and its main metabolite albendazole sulfoxide in plasma and cerebrospinal fluid. J. Chromatogr. 494: 403-407
6. Jung, H., Hurtado, M., Sanchez, M., Medina, M. T., Sotelo, J. (1990) Plasma and CSF levels of albendazole and praziquantel in patients with neurocysticercosis. Clin. Neuropharm. 13: 559-564
7. Jung, H., Hurtado, M., Sanchez, M., Medina, M. T., Sotelo, J. (1992) Clinical pharmacokinetic of albendazole in patients with brain cysticercosis. Clin. Pharmacol. 32: 28-31
8. Jung, H., Sanchez, M., Gonzalez-Astiazarán, A., Martinez, J., Suástegui, R., Gonzalez-Esquivel, D. (1997) Clinical pharmacokinetics of albendazole in children with neurocysticercosis. Am. J. Ther. 4: 23-26
9. Lange, H., Eggers, R., Bercher, F. (1988) Increased systemic availability of albendazole when taken with a fatty meal. Eur. J. Clin. Pharmacol. 34: 315-317
10. Marriner, S. E., Morris, D. L., Dickson, B., Bogan, J. A. (1986) Pharmacokinetics of albendazole in man. Eur. J. Clin. Pharmacol. 30: 705-708
11. Morris, D. L., Dykes, P. W., Dickson, B., Marriner, S. E., Bogan, J. A., Burrows, F. G. O. (1983) Albendazole in hydatid disease. Br. Med. J. 286: 103-104
12. a Prediction for Organic Acids and Bases. Chapman & Hall, London
13. Prieto, J. G., Alonso, M. I., Justel, A., Santos, L. (1988) Tissue levels of albendazole after in-vivo intestinal and gastric absorption in rats. J. Pharmacol. Biomed. Anal. 6: 1059-1063
14. Prieto, J. G., Justel, A., Del Estal, J. L., Barrio, J. P., Alvarez, A. I. (1991) Comparative study on gastric absorption of albendazole and mebendazole in rats. Comp. Biochem. Physiol. 100C: 397-400
15. Sotelo, J., Escobedo, F., Penagos, P. (1988) Albendazole vs. praziquantel for therapy for neurocysticercosis. Arch. Neurol. 45: 532-534