Improving bioavailability and anthelmintic activity of albendazole by preparing albendazole-cyclodextrin complexes

Parasite

Volumn 8, Issue , 2001, Pages S188-S190

  Garcia Rodriguez J J ^a   Torrado, J ^a   Bolas F ^a  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

Albendazole; Bioavailability; Cyclodextrins; Trichinella

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; 2-HYDROXYPROPYL-BETA-CYCLODEXTRIN; ALBENDAZOLE; ANTHELMINTIC AGENT; BETA CYCLODEXTRIN DERIVATIVE; CYCLODEXTRIN; DIAGNOSTIC AGENT; EXCIPIENT;

ANIMAL; ARTICLE; BIOAVAILABILITY; BLOOD; MOUSE; ORAL DRUG ADMINISTRATION; STEREOISOMERISM; TIME; TRICHINELLA SPIRALIS; TRICHINOSIS;

ADMINISTRATION, ORAL; ALBENDAZOLE; ANIMALS; ANTHELMINTICS; BETA-CYCLODEXTRINS; BIOLOGICAL AVAILABILITY; CYCLODEXTRINS; EXCIPIENTS; MICE; STEREOISOMERISM; TIME FACTORS; TRICHINELLA SPIRALIS; TRICHINOSIS;

EID: 0035379090     PISSN: 1252607X     EISSN: None     Source Type: Journal    
DOI: 10.1051/parasite/200108s2188     Document Type: Article

References (7)

1. CASTILLO J.A., PALOMO-CANALES J., GARCIA J.J., LASTRES J.L., BOLAS, F. & TORRADO J.J. Preparation and characterization of albendazole ß-cyclodextrin complexes. Drug Development and Industrial Pharmacy, 1999, 25, 1241-1248.
2. DELATOUR P., BENOIT E., CAUDE M. & TAMBUTE A. Species differencing the generation of the chiral sulphoxide metabolite of albendazole in sheep and rats. Chirality, 1990, 2, 156-160.
3. DENHAM D. & MARTINEZ A.R.M. Studies with methyridine and Trichinella spiralis. II. The use of the drug to study the rate of larval production in mice. Journal of Helminthology, 1970, 44, 357-363.
4. GARCIA J.J., BOLAS-FERNANDEZ F. & TORRADO J.J. Quantitative determination of albendazole and its main metabolites in plasma. Journal of Chromatography B, 1999, 723, 265-271.
5. GYURIK R. J., CHOW A.W., ZABER B., BRUNER E.L., MILLER J. A., VILLANI A.J., PETKA L.A. & PARISH R.C. Metabolism of albendazole in cattle, sheep, rats and mice. Drug metabolism and disposition, 1981, 9, 503-508.
6. LOPEZ M.L., TORRADO S., TORRADO S., MARTINEZ A.R. & BOLAS F. Improvement of albendazole efficacy against enteral, but not against parenteral stages of Trichinella spiralis by preparing solid dispersion in polyvinylpyrrolidone. Chemotherapy, 1997, 43, 430-435.
7. VILLAVERDE C., ALVAREZ I., DEL ESTAL J.L. & PRIETO J.G. Albendazole and mebendazole uptake by isolated enterocytes. Dev. Pharmacol. Ther., 1992, 19, 27-31.