Handling and analysis of cells and bioparticles on centrifugal microfluidic platforms

Expert Review of Molecular Diagnostics

Volumn 12, Issue 4, 2012, Pages 407-421

  Burger, Robert ^a   Ducrée, Jens ^a  

^a DUBLIN CITY UNIVERSITY   (Ireland)

Author keywords

blood separation; cell assay; cell capturing; cell sorting; centrifugal microfluidics; lab on a disc; optical disc drive; point of care diagnostics

Indexed keywords

CELL ENCAPSULATION; CELL SEPARATION; CENTRIFUGAL ANALYZER; CENTRIFUGE; CYTOLYSIS; CYTOMETRY; ELECTROPHORESIS; FLOW CYTOMETRY; HUMAN; MICROFLUIDIC ANALYSIS; MICROFLUIDICS; REVIEW;

CENTRIFUGATION; FLOW CYTOMETRY; MICROFLUIDICS; MINIATURIZATION;

EID: 84861439560     PISSN: 14737159     EISSN: 17448352     Source Type: Journal    
DOI: 10.1586/erm.12.28     Document Type: Review

References (113)

1. Englert DL, Manson MD, Jayaraman A. Flow-based microfluidic device for quantifying bacterial chemotaxis in stable, competing gradients. Appl. Environ. Microbiol. 75(13), 4557-4564 (2009
2. Yu HM, Meyvantsson I, Shkel IA, Beebe DJ. Diffusion dependent cell behavior in microenvironments. Lab. Chip 5(10), 1089-1095 (2005
3. Reyes D, Iossifidis D, Auroux P, Manz A. Micro total analysis systems. 1. Introduction, theory, and technology. Anal. Chem. 74(12), 2623-2636 (2002
4. Vilkner T, Janasek D, Manz A. Micro total analysis systems. Recent developments. Anal. Chem. 76(12), 3373-3385 (2004
5. Auroux P, Iossifidis D, Reyes D, Manz A. Micro total analysis systems. 2. Analytical standard operations and applications. Anal. Chem. 74(12), 2637-2652 (2002
6. Weibel DB, DiLuzio WR, Whitesides GM. Microfabrication meets microbiology. Nat. Rev. Microbiol. 5(3), 209-218 (2007
7. Andersson H, van den Berg A. Microfluidic devices for cellomics: a review. Sens. Actuator B-Chem. 92(3), 315-325 (2003
8. Huh D, Gu W, Kamotani Y, Grotberg J, Takayama S. Microfluidics for flow cytometric analysis of cells and particles. Physiol. Meas. 26(3), R73-R98 (2005
9. Erickson D, Li D. Integrated microfluidic devices. Anal. Chim. Acta 507(1), 11-26 (2004
10. Andersson-Svahn H, van den Berg A. Single cells or large populations? Lab. Chip 7(5), 544-546 (2007
11. El-Ali J, Sorger PK, Jensen KF. Cells on chips. Nature 442(7101), 403-411 (2006
12. Lindström S, Andersson-Svahn H. Overview of single-cell analyses: microdevices and applications. Lab. Chip 10(24), 3363-3372 (2010
13. Yi C, Li C, Ji S, Yang M. Microfluidics technology for manipulation and analysis of biological cells. Anal. Chim. Acta 560(1-2), 1-23 (2006
14. Bhagat AAS, Bow H, Hou HW, Tan SJ, Han J, Lim CT. Microfluidics for cell separation. Med. Biol. Eng. Comput. 48(10), 999-1014 (2010
15. Madou M, Zoval J, Jia G, Kido H, Kim J, Kim N. Lab on a CD. Annu. Rev. Biomed. Eng. 8, 601-628 (2006
16. Ducrée J, Haeberle S, Lutz S, Pausch S, von Stetten F, Zengerle R. The centrifugal microfluidic bio-disk platform. J. Micromech. Microeng. 17(7), S103-S115 (2007
17. Rocco RM. Landmark papers in clinical chemistry. Elsevier Science, Amsterdam, The Netherlands, 2005.
18. Burtis C, Anderson N, Mailen J, Scott C, Tiffany T, Johnson W. Development of a miniature fast analyzer. Clin. Chem. 18(8), 753-761 (1972
19. Burtis C, Johnson W, Mailen J, Overton J, Tiffany T, Watsky M. Development of an analytical system based around a miniature fast analyzer. Clin. Chem. 19(8), 895-903 (1973
20. Mark D, Metz T, Haeberle S et al. Centrifugo-pneumatic valve for metering of highly wetting liquids on centrifugal microfluidic platforms. Lab. Chip 9(24), 3599-3603 (2009
21. Cho YK, Lee JG, Park JM, Lee BS, Lee Y, Ko C. One-step pathogen specific DNA extraction from whole blood on a centrifugal microfluidic device. Lab. Chip 7(5), 565-573 (2007
22. Abi-Samra K, Hanson R, Madou M, Gorkin RA 3rd. Infrared controlled waxes for liquid handling and storage on a CD-microfluidic platform. Lab. Chip 11(4), 723-726 (2011
23. Park J, Cho Y, Lee B, Lee J, Ko C. Multifunctional microvalves control by optical illumination on nanoheaters and its application in centrifugal microfluidic devices. Lab. Chip 7(5), 557-564 (2007
24. Siegrist J, Gorkin R, Clime L et al. Serial siphon valving for centrifugal microfluidic platforms. Microfluidics Nanofluidics 9(1), 55-63 (2010
25. Steigert J, Brenner T, Grumann M et al. Integrated siphon-based metering and sedimentation of whole blood on a hydrophilic lab-on-a-disk. Biomed. Microdevices 9(5), 675-679 (2007
26. Andersson P, Jesson G, Kylberg G, Ekstrand G, Thorsen G. Parallel nanoliter microfluidic analysis system. Anal. Chem. 79(11), 4022-4030 (2007
27. Ducrée J, Brenner T, Haeberle S, Glatzel T, Zengerle R. Multilamination of flows in planar networks of rotating microchannels. Microfluidics Nanofluidics 2(1), 78-84 (2006
28. Ducrée J, Haeberle S, Brenner T, Glatzel T, Zengerle R. Patterning of flow and mixing in rotating radial microchannels. Microfluidics Nanofluidics 2(2), 97-105 (2006
29. Grumann M, Geipel A, Riegger L, Zengerle R, Ducrée J. Batch-mode mixing on centrifugal microfluidic platforms. Lab. Chip. 5(5), 560-565 (2005
30. Bynum M, Gordon G. Hybridization enhancement using microfluidic planetary centrifugal mixing. Anal. Chem. 76(23), 7039-7044 (2004
31. Noroozi Z, Kido H, Micic M et al. Reciprocating flow-based centrifugal microfluidics mixer. Rev. Sci. Instrum. 80(7), 075102 (2009
32. Gorkin R, Park J, Siegrist J et al. Centrifugal microfluidics for biomedical applications. Lab. Chip 10(14), 1758-1773 (2010
33. Lee WC, Bhagat AAS, Huang S, Van Vliet KJ, Han J, Lim CT. High-throughput cell cycle synchronization using inertial forces in spiral microchannels. Lab. Chip 11(7), 1359-1367 (2011
34. Bhagat AAS, Kuntaegowdanahalli SS, Papautsky I. Continuous particle separation in spiral microchannels using dean flows and differential migration. Lab. Chip 8(11), 1906-1914 (2008
35. Ookawara S, Higashi R, Street D, Ogawa K. Feasibility study on concentration of slurry and classification of contained particles by microchannel. Chem. Eng. J. 101(1-3), 171-178 (2004
36. Ookawara S, Street D, Ogawa K. Numerical study on development of particle concentration profiles in a curved microchannel. Chem. Eng. Sci. 61(11), 3714-3724 (2006
37. Bhagat AAS, Kuntaegowdanahalli SS, Kaval N, Seliskar CJ, Papautsky I. Inertial microfluidics for sheath-less high-throughput flow cytometry. Biomed. Microdevices 12(2), 187-195 (2010
38. Seo J, Lean MH, Kole A. Membrane-free microfiltration by asymmetric inertial migration. Appl. Phys. Lett. 91(3), 033901-033903 (2007
39. Blattert C, Jurischka R, Tahhan I, Schoth A, Kerth P, Menz W. Separation of blood cells and plasma in microchannel bend structures. Presented at: 8th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Malmo, Sweden, 26-30 September 2004.
40. Blattert C, Jurischka R, Tahhan I, Schoth A, Kerth P, Menz W. Separation of blood in microchannel bends. Presented at: Engineering in Medicine and Biology Society, 2004. IEMBS '04. 26th Annual International Conference of the IEEE. 1-5 September 2004.
41. Amasia M, Madou M. Large-volume centrifugal microfluidic device for blood plasma separation. Bioanalysis 2(10), 1701-1710 (2010
42. Haeberle S, Brenner T, Zengerle R, Ducrée J. Centrifugal extraction of plasma from whole blood on a rotating disk. Lab. Chip 6(6), 776-781 (2006
43. Zhang JL, Guo QQ, Liu M, Yang J. A lab-on-CD prototype for high-speed blood separation. J. Micromech. Microeng. 18(12), (2008
44. Schembri CT, Burd TL, Kopfsill AR, Shea LR, Braynin B. Centrifugation and capillarity integrated into a multiple analyte whole-blood analyzer. J. Automat. Chem. 17(3), 99-104 (1995
45. Burger R, Reis N, Fonseca JG, Ducrée J. Blood separation based on pressure driven membrane deflection. Presented at: The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS). Jeju, South Korea, 1-5 November 2009.
46. Lee BS, Lee J, Park J et al. A fully automated immunoassay from whole blood on a disc. Lab. Chip 9(11), 1548-1555 (2009
47. Lutz S, Lang P, Faltin B et al. Towards a comprehensive centrifugal process integration by rotationally induced lyophilisate dissolution and cell lysis. Presented at: 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Paris, France, 7-11 October 2007.
48. Kellogg GJ, Arnold TE, Carvalho BL, Duffy DC, Sheppard NF. Centrifugal microfluidics: applications. Presented at: 4th International Conference on Miniaturized Systems for Chemistry and Life Sciences. Twente, The Netherlands, 14-18 May 2000.
49. Klepárnik K, Horky M. Detection of DNA fragmentation in a single apoptotic cardiomyocyte by electrophoresis on a microfluidic device. Electrophoresis 24(21), 3778-3783 (2003
50. Kido H, Micic M, Smith D, Zoval J, Norton J, Madou M. A novel, compact disk-like centrifugal microfluidics system for cell lysis and sample homogenization. Colloids Surfaces B-Biointerfaces 58(1), 44-51 (2007
51. Siegrist J, Gorkin R, Bastien M et al. Validation of a centrifugal microfluidic sample lysis and homogenization platform for nucleic acid extraction with clinical samples. Lab. Chip 10(3), 363-371 (2010
52. Kim J, Jang SH, Jia GY, Zoval JV, Da Silva NA, Madou MJ. Cell lysis on a microfluidic CD (compact disc). Lab. Chip 4(5), 516-522 (2004
53. Riegger L, Grumann M, Steigert J et al. Single-step centrifugal hematocrit determination on a 10-$ processing device. Biomed. Microdevices 9(6), 795-799 (2007
54. Garcia-Cordero JL, Barrett LM, O'Kennedy R, Ricco AJ. Microfluidic sedimentation cytometer for milk quality and bovine mastitis monitoring. Biomed. Microdevices 12(6), 1051-1059 (2010
55. Schaff UY, Tentori AM, Sommer GJ. Differential white cell count by centrifugal microfluidics. Presented at: 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences . Groningen, The Netherlands, 3-7 October 2010.
56. Chen P, Feng X, Hu R, Sun J, Du W, Liu B. Hydrodynamic gating valve for microfluidic fluorescence-activated cell sorting. Anal. Chim. Acta 663(1), 1-6 (2010
57. Wang L, Flanagan LA, Jeon NL, Monuki E, Lee AP. Dielectrophoresis switching with vertical sidewall electrodes for microfluidic flow cytometry. Lab. Chip 7(9), 1114-1120 (2007
58. Voldman J, Gray ML, Toner M, Schmidt MA. A microfabrication-based dynamic array cytometer. Anal. Chem. 74(16), 3984-3990 (2002
59. Doh I, Cho Y. A continuous cell separation chip using hydrodynamic dielectrophoresis (DEP) process. Sens. Actuators A-Phys. 121(1), 59-65 (2005
60. Yellen BB, Erb RM, Son HS, Hewlin R, Shang H, Lee GU. Traveling wave magnetophoresis for high resolution chip based separations. Lab. Chip 7(12), 1681-1688 (2007
61. Di Carlo D. Inertial microfluidics. Lab. Chip 9(21), 3038-3046 (2009
62. Hur SC, Tse HTK, Di Carlo D. Sheathless inertial cell ordering for extreme throughput flow cytometry. Lab. Chip 10(3), 274-280 (2010
63. Oakey J, Applegate RW, Arellano E, Di Carlo D, Graves SW, Toner M. Particle focusing in staged inertial microfluidic devices for flow cytometry. Anal. Chem. 82(9), 3862-3867 (2010
64. Shiono H, Ito Y. Novel method for continuous cell separation by density gradient centrifugation: evaluation of a miniature separation column. Prep. Biochem. Biotechnol. 33(2), 87-100 (2003
65. Shiono H, Chen HM, Okada T, Ito Y. Colony-forming cell assay for human hematopoietic progenitor cells harvested by a novel continuous-flow cell separation method. J. Chromatogr. A 1151(1-2), 153-157 (2007
66. Shiono H, Okada T, Ito Y. Application of a novel continuous-flow cell separation method for separation of cultured human mast cells. J. Liq. Chromatogr. Rel. Technol. 28(12-13), 2071-2083 (2005
67. Yamada M, Nakashima M, Seki M. Pinched-flow fractionation: continuous size separation of particles utilizing a laminar flow profile in a pinched microchannel. Anal. Chem. 76(18), 5465-5471 (2004
68. Morijiri T, Sunahiro S, Senaha M, Yamada M, Seki M. Sedimentation pinched-flow fractionation for size- and density-based particle sorting in microchannels. Microfluidics Nanofluidics 11(1), 105-110 (2011
69. Banfalvi G. Cell cycle synchronization of animal cells and nuclei by centrifugal elutriation. Nat. Protoc. 3(4), 663-673 (2008
70. Donaldson K, McShea A, Wahl A. Separation by counterflow centrifugal elutriation and analysis of T- and B-lymphocytic cell lines in progressive stages of cell division cycle. J. Immunol. Methods 203(1), 25-33 (1997
71. Morijiri T, Hikida T, Yamada M, Seki M. Microfluidic counterflow centrifugal elutriation for cell separation using density-gradient media. Presented at: 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS). Groningen, The Netherlands, 3-7 October 2010.
72. Martinez-Duarte R, Gorkin RA 3rd, Abi- Samra K, Madou MJ. The integration of 3D carbon-electrode dielectrophoresis on a CD-like centrifugal microfluidic platform. Lab. Chip 10(8), 1030-1043 (2010
73. Boettcher M, Jaeger MS, Riegger L, Ducrée J, Zengerle R, Duschl C. Lab-on-chip-based cell separation by combining dielectrophoresis and centrifugation. Biophys. Rev. Lett. 1(4), 443-451 (2006
74. Pamme N. Magnetism and microfluidics. Lab. Chip 6(1), 24-38 (2006
75. Bronzeau S, Pamme N. Simultaneous bioassays in a microfluidic channel on plugs of different magnetic particles. Anal. Chim. Acta 609(1), 105-112 (2008
76. Pamme N, Wilhelm C. Continuous sorting of magnetic cells via on-chip free-flow magnetophoresis. Lab. Chip 6(8), 974-980 (2006
77. Siegrist J, Zavattoni L, Burger R, Ducrée J. 2-dimensional separation of biomimetic particles by stopped-flow centrifugo-magnetophoresis. Presented at: 16th International Solid-State Sensors, Actuators and Microsystems Conference (Transducers). Beijing, China, 5-9 June 2011.
78. Siegrist J, Burger R, Kirby D, Zavattoni L, Kijanka G, Ducrée J. Stress-free centrifugo-magnetic 2D-separation of cancer cells in a stopped-flow mode. Presented at: 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS). Seattle, USA, 2-6 October 2011.
79. Siegrist J, Zavattoni L, Ducrée J. Centrifugo-magnetophoretic separation and routing of particles. Presented at: IEEE 24th International Conference on Micro Electro Mechanical Systems (MEMS). Cancun, Mexico, 23-27 January 2011.
80. Chen C, Chen K, Pan Y et al. Separation and detection of rare cells in a microfluidic disk via negative selection. Lab. Chip 11(3), 474-483 (2011
81. Chen K, Lee T, Pan Y et al. Detection of circulating endothelial cells via a microfluidic disk. Clin. Chem. 57(4), 586-592 (2011
82. Häberle S, Naegele L, Burger R, Von Stetten F, Zengerle R, Ducrée J. Alginate bead fabrication and encapsulation of living cells under centrifugally induced artificial gravity conditions. J. Microencapsul. 25(4), 267-274 (2008
83. Kubo I, Furutani S, Matoba K. Use of a novel microfluidic disk in the analysis of single-cell viability and the application to Jurkat cells. J. Biosci. Bioeng. 112(1), 98-101 (2011
84. Lee S, Kang JY, Lee I et al. Single-cell assay on CD-like lab chip using centrifugal massive single-cell trap. Sens. Actuators A Phys. 143(1), 64-69 (2008
85. Furutani S, Nagai H, Takamura Y, Kubo I. Compact disk (CD)-shaped device for single cell isolation and PCR of a specific gene in the isolated cell. Anal. Bioanal. Chem. 398(7-8), 2997-3004 (2010
86. Chen H, Li X, Wang L, Li PCH. A rotating microfluidic array chip for staining assays. Talanta 81(4-5), 1203-1208 (2010
87. Riegger L, Grumann M, Nann T et al. Read-out concepts for multiplexed bead-based fluorescence immunoassays on centrifugal microfluidic platforms. Sens. Actuators A Phys. 126(2), 455-462 (2006
88. Burger R, Reith P, Kijanka G, Akujobi V, Abgrall P, Ducrée J. Array-based capture, distribution, counting and multiplexed assaying of beads on a centrifugal microfluidic platform. Lab. Chip (7), 1295 (2012).
89. Burger R, Reith P, Abgrall P, Kijanka G, Ducrée J. Multiplexing of highly reproducible, bead-based immunoassays on a centrifugal microfluidic platform. Presented at: 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems (MEMS). Cancun, Mexico, 23-27 January 2011.
90. Burger R, Kijanka G, Sheils O, O'Leary J, Ducrée J. Arrayed capture, assaying and binary counting of cells in a stopped-flow sedimentation mode. Presented at: 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS). Seattle, Washington, USA, 2-6 October 2011.
91. Burger R, Reith P, Abgrall P, Ducrée J. Integration of high-efficiency capture and magneto-hydrodynamic retrieval of particles on a centrifugal microfluidic platform. Presented at: 2011 IEEE 24th International Conference on Micro Electro Mechanical Systems (MEMS). Cancun, Mexico, 23-27 January 2011.
92. Cho H, Lee LP. A novel integrated microfluidic SERS-CD with high-throughput centrifugal cell trapping array for quantitative biomedicine. Presented at: The 10th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS). Tokyo, Japan, 5-9 November 2006.
93. Rothert A, Deo SK, Millner L, Puckett LG, Madou MJ, Daunert S. Whole-cell-reporter-gene-based biosensing systems on a compact disk microfluidics platform. Anal. Biochem. 342(1), 11-19 (2005
94. Date A, Pasini P, Daunert S. Integration of spore-based genetically engineered whole-cell sensing systems into portable centrifugal microfluidic platforms. Anal. Bioanal. Chem. 398(1), 349-356 (2010
95. Kim N, Dempsey CM, Zoval JV, Sze J, Madou MJ. Automated microfluidic compact disc (CD) cultivation system of Caenorhabditis elegans. Sens. Actuators B Chem. 122(2), 511-518 (2007
96. Fan K, Lin C, Shyu L. The development of a low-cost focusing probe for profile measurement. Meas. Sci. Technol. 11(1), N1-N7 (2000
97. Bartoli A, Poggi P, Quercioli F, Tiribilli B. Fast one-dimensional profilometer with a compact disc pickup. Appl. Opt. 40(7), 1044-1048 (2001
98. Kostner S, Vellekoop MJ. Cell analysis in a microfluidic cytorneter applying a DVD pickup head. Sens. Actuator B Chem. 132(2), 512-517 (2008
99. Imaad SM, Lord N, Kulsharova G, Liu GL. Microparticle and cell counting with digital microfluidic compact disc using standard CD drive. Lab. Chip 11(8), 1448-1456 (2011
100. Chen H, Wang L, Li PCH. Nucleic acid microarrays created in the double-spiral format on a circular microfluidic disk. Lab. Chip 8(5), 826-829 (2008
101. La Clair J, Burkart M. Molecular screening on a compact disc. Org. Biomol. Chem. 1(18), 3244-3249 (2003
102. Morais S, Carrascosa J, Mira D, Puchades R, Maquieira A. Microimmunoanalysis on standard compact discs to determine low abundant compounds. Anal. Chem. 79(20), 7628-7635 (2007
103. Lange SA, Roth G, Wittemann S et al. Measuring biomolecular binding events with a compact disc player device. Angew. Chem. 45(2), 270-273 (2006
104. Barathur R, Bookout J, Sreevatsan S et al. New disc-based technologies for diagnostic and research applications. Psychiatr. Genet. 12(4), 193-206 (2002
105. Yu H. New chemistry on old CDs. Chem. Commun. 23, 2633-2636 (2004
106. Bosco FG, Hwu E, Chen C et al. High throughput label-free platform for statistical bio-molecular sensing. Lab. Chip 11(14), 2411-2416 (2011
107. Cristofanilli M, Budd G, Ellis M et al. Circulating tumor cells, disease progression, and survival in metastatic breast cancer. N. Engl. J. Med. 351(8), 781-791 (2004
108. Yu M, Stott S, Toner M, Maheswaran S, Haber DA. Circulating tumor cells: approaches to isolation and characterization. J. Cell. Biol. 192(3), 373-382 (2011
109. Nagrath S, Sequist LV, Maheswaran S et al. Isolation of rare circulating tumour cells in cancer patients by microchip technology. Nature 450(7173), 1235-1239 (2007
110. Allard W, Matera J, Miller M et al. Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases. Clin. Cancer Res. 10(20), 6897-6904 (2004
111. Garcia-Cordero JL, Basabe-Desmonts L, Ducrée J, Ricco AJ. Liquid recirculation in microfluidic channels by the interplay of capillary and centrifugal forces. Microfluidics Nanofluidics 9(4-5), 695-703 (2010
112. Haeberle S, Schmitt N, Zengerle R, Ducrée J. Centrifugo-magnetic pump for gas-to-liquid sampling. Sens.Actuators A Phys. 135(1), 28-33 (2007
113. Haeberle S, Zengerle R, Ducrée J. Centrifugal generation and manipulation of droplet emulsions. Microfluidics Nanofluidics 3(1), 65-75 (2007