Drug release from poly(dimethylsiloxane)-based matrices: Observed and predicted stabilization of the release rate by three-layer devices

Industrial and Engineering Chemistry Research

Volumn 51, Issue 20, 2012, Pages 7126-7136

  Soulas, Dimitrios N ^a   Papadokostaki, Kyriaki G ^a   Panou, Athanasia ^a   Sanopoulou, Merope ^a  

^a INSTITUTE OF NANOSCIENCE AND NANOTECHNOLOGY   (Greece)

Author keywords

[No Author keywords available]

Indexed keywords

DEVELOPED MODEL; DEVICE PARAMETERS; DRUG RELEASE; EXPERIMENTAL SYSTEM; GEOMETRICAL CHARACTERISTICS; INNER LAYER; INPUT PARAMETER; KINETIC CHARACTERISTICS; MATHEMATICAL MODELING; MODEL CALCULATIONS; OPTIMUM DESIGNS; OUTER LAYER; RELEASE EXPERIMENTS; RELEASE RATE; SINGLE LAYER; SINGLE LAYER DEVICES; THREE-LAYER;

POLYETHYLENE GLYCOLS; TRANSPORT PROPERTIES;

DRUG PRODUCTS;

EID: 84861436943     PISSN: 08885885     EISSN: 15205045     Source Type: Journal    
DOI: 10.1021/ie300540x     Document Type: Article

References (59)

1. Roseman, T. J. Release of steroids from a silicone polymer J. Pharm. Sci. 1972, 61, 46-50
2. Ulman, K. L.; Larson, K. R.; Lee, C.-L. Drug permeability of modified silicone rubber polymers. II. Silicone-organic graft copolymers J. Controlled Release 1989, 10, 261-272 (Pubitemid 20027146)
3. Woolfson, A. D.; Elliott, G. R. E.; Gilligan, C. A.; Passmore, C. M. Design of an intravaginal ring for the controlled delivery of 17β-estradiol as its 3-acetate ester J. Controlled Release 1999, 61, 319-328 (Pubitemid 29413026)
4. Ueno, N.; Refojo, M. F.; Liu, L. H. S. Controlled release rate of a lipophilic drug (BCNU) from a refillable silicone-rubber device J. Biomed. Mater. Res. 1982, 16, 669-677 (Pubitemid 12009644)
5. Kajihara, M.; Sugie, T.; Sano, A.; Fujioka, K.; Urabe, Y.; Tanihara, M.; Imanishi, Y. Novel method to control release of lipophilic drugs with high potency from silicone Chem. Pharm. Bull. 2003, 51, 11-14 (Pubitemid 41702008)
6. Malcolm, R. K.; McCullagh, S. D.; Woolfson, A. D.; Gorman, S. P.; Jones, D. S.; Cuddy, J. Controlled release of a model antibacterial drug from a novel self-lubricating silicone biomaterial J. Controlled Release 2004, 97, 313-320 (Pubitemid 38759488)
7. Carelli, V.; Dicolo, G.; Guerrini, C.; Nannipieri, E. Drug release from silicone elastomer through controlled polymer cracking - an extension to macromolecular drugs Int. J. Pharm. 1989, 50, 181-188 (Pubitemid 19063335)
8. Dash, A. K.; Suryanarayanan, R. An implantable dosage form for the treatment of bone infections Pharm. Res. 1992, 9, 993-1002
9. Woolfson, A. D.; Malcolm, R. K.; Morrow, R. J.; Toner, C. F.; McCullagh, S. D. Intravaginal ring delivery of the reverse transcriptase inhibitor TMC 120 as an HIV microbicide Int. J. Pharm. 2006, 325, 89-89
10. Amsden, B. A model for osmotic pressure driven release from cylindrical rubbery polymer matrices J. Controlled Release 2003, 93, 249-258 (Pubitemid 37485947)
11. Chapanian, R.; Amsden, B. G. Osmotically driven protein release from photocross-linked elastomers of poly(trimethylene carbonate) and poly(trimethylene carbonate-co-d,l-lactide) Eur. J. Pharm. Biopharm. 2010, 74, 172-183
12. Riggs, P. D.; Kinchesh, P.; Braden, M.; Patel, M. P. Nuclear magnetic imaging of an osmotic water uptake and delivery process Biomaterials 2001, 22, 419-427 (Pubitemid 32007846)
13. Schirrer, R.; Thepin, P.; Torres, G. Water absorption, swelling, rupture and salt release in salt-silicone rubber compounds J. Mater. Sci. 1992, 27, 3424-3434
14. Soulas, D. N.; Papadokostaki, K. G. Regulation of proxyphylline's release from silicone rubber matrices by the use of osmotically active excipients and a multi-layer system Int. J. Pharm. 2011, 408, 120-129
15. Soulas, D. N.; Sanopoulou, M.; Papadokostaki, K. G. Comparative study of the release kinetics of osmotically active solutes from hydrophobic elastomeric matrices combined with the characterization of the depleted matrices J. Appl. Polym. Sci. 2009, 113, 936-949
16. Kajihara, M.; Sugie, T.; Hojo, T.; Mizuno, M.; Tamura, N.; Sano, A.; Fujioka, K.; Kashiwazaki, Y.; Yamaoka, T.; Sugawara, S.; Urabe, Y. Development of a new drug delivery system for protein drugs using silicone (I) J. Controlled Release 2000, 66, 49-61 (Pubitemid 30116684)
17. Gao, Z.; Shulze Nahrup, J.; Mark, J. E.; Sakr, A. Poly(dimethylsiloxane) coatings for controlled drug release.III. Drug release profiles and swelling properties of the free-standing films J. Appl. Polym. Sci. 2005, 96, 494-501 (Pubitemid 40430262)
18. Shulze Nahrup, J.; Gao, Z. M.; Mark, J. E.; Sakr, A. Poly(dimethylsiloxane) coatings for controlled drug release-polymer modifications Int. J. Pharm. 2004, 270, 199-208 (Pubitemid 38077100)
19. Andreopoulos, A. G.; Plytaria, M. Biomedical silicone elastomers as carriers for controlled release J. Biomater. Appl. 1998, 12, 258-271 (Pubitemid 128593649)
20. Aschkenasy, C.; Kost, J. On-demand release by ultrasound from osmotically swollen hydrophobic matrices J. Controlled Release 2005, 110, 58-66 (Pubitemid 41713931)
21. Gale, R.; Chandrasekaran, S. K.; Swanson, D.; Wright, J. Use of osmotically active therapeutic agents in monolithic systems J. Membr. Sci. 1980, 7, 319-331 (Pubitemid 11192795)
22. Soulas, D. N.; Papadokostaki, K. G. Experimental investigation of the release mechanism of proxyphylline from silicone rubber matrices J. Appl. Polym. Sci. 2011b, 120, 821-830
23. Lei, L.; Liu, X.; Shen, Y.-Y.; Liu, J.-Y.; Tang, M.-F.; Wang, Z.-M.; Guo, S.-R.; Cheng, L. Zero-order release of 5-fluorouracil from PCL-based films featuring trilayered structures for stent application Eur. J. Pharm. Biopharm. 2011, 78, 49-57
24. Paul, D. R. Elaborations on the Higuchi model for drug delivery Int. J. Pharm. 2011, 418, 13-17
25. Bodmeier, R.; Paeratakul, O. Drug release from laminated polymeric films prepared from aqueous latexes J. Pharm. Sci. 1990, 79, 32-36 (Pubitemid 20148510)
26. Huang, Y.-Y.; Chung, T.-W.; Tzeng, T.-W. A method using biodegradable polylactides/polyethylene glycol for drug release with reduced initial burst Int. J. Pharm. 1999, 182, 93-100 (Pubitemid 29231317)
27. Huang, Y.; Venkatraman, S. S.; Boey, F. Y. C.; Lahti, E. M.; Umashankar, P. R.; Mohanty, M.; Arumugam, S.; Khanolkar, L.; Vaishnav, S. In vitro and in vivo performance of a dual drug-eluting stent (DDES) Biomaterials 2010, 31, 4382-4391
28. Lei, L.; Liu, X.; Guo, S.; Tang, M.; Cheng, L.; Tian, L. 5-Fluorouracil-loaded multilayered films for drug controlled releasing stent application: Drug release, microstructure, and ex vivo permeation behaviours J. Controlled Release 2010, 146, 45-53
29. Maeda, H.; Ohashi, E.; Sano, A.; Kawasaki, H.; Kurosaki, Y. Investigation of the release behavior of a covered-rod-type formulation using silicone J. Controlled Release 2003, 90, 59-70 (Pubitemid 36588879)
30. Watkins, A. W.; Southard, S. L.; Anseth, K. S. Characterizing multilaminated hydrogels with spatially varying network structure and solute loading using confocal laser scanning microscopy Acta Biomater. 2007, 3, 439-448 (Pubitemid 46865773)
31. Chapanian, R.; Amsden, B. G. Combined and sequential delivery of bioactive VEGF165 and HGF from poly(trimethyl carbonate) based photo-cross-linked elastomers J. Controlled Release 2010, 143, 53-63
32. Helbling, I. M.; Ibarra, J. C. D.; Luna, J. A.; Cabrera, M. I.; Grau, R. J. A. Modeling of dispersed-drug delivery from planar polymeric systems: Optimizing analytical solutions Int. J. Pharm. 2010, 400, 131-137
33. Helbling, I. M.; Luna, J. A.; Cabrera, M. I. Mathematical modeling of drug delivery from torus-shaped single-layer devices J. Controlled Release 2011, 149, 258-263
34. Lee, P. I. Initial concentration distribution as a mechanism for regulating drug release from diffusion controlled and surface erosion controlled matrix systems J. Controlled Release 1986, 4, 2-7
35. Lu, S.; Ramirez, W. F.; Anseth, K. S. Modelling and optimization of drug release from laminated polymer matrix devices AIChE J. 1998, 44, 1689-1696 (Pubitemid 128768968)
36. Nauman, E. B.; Patel, K.; Karande, P. On the design and optimization of diffusion-controlled, planar delivery devices Chem. Eng. Sci. 2010, 65, 923-930
37. Papadokostaki, K. G.; Stavropoulou, A.; Sanopoulou, M.; Petropoulos, J. H. An advanced model for composite planar three-layer matrix-controlled release devices. Part I. Devices of uniform material properties and non-uniform solute load J. Membr. Sci. 2008, 312, 193-206
38. Papadokostaki, K. G.; Sanopoulou, M.; Petropoulos, J. H. An advanced model for composite planar three-layer matrix-controlled release devices. Part II. Devices with non-uniform material properties and a practical example J. Membr. Sci. 2009, 343, 128-136
39. Siepmann, F.; Eckart, K.; Maschke, A.; Kolter, K.; Siepmann, J. Modeling drug release from PVAc/PVP matrix tablets J. Controlled Release 2010, 141, 216-222
40. Siepmann, J.; Siepmann, F. Modeling of diffusion controlled drug delivery J. Controlled Release 2012, 10.1016/j.jconrel.2011.10.006
41. Sirianni, R. W.; Jang, E.-H.; Miller, K. H.; Saltzman, W. M. Parameter estimation methodology in a model of hydrophobic drug release from a polymer coating J. Controlled Release 2010, 142, 474-482
42. Wu, L.; Brazel, C. S. Theoretical verification of surface cross-linking as effective method to reduce initial burst release from swellable hydrogels Ind. Eng. Chem. Res. 2008, 47, 5986-5993
43. Wu, X. Y.; Zhou, Y. Finite element analysis of diffusional drug release from complex matrix systems. II. Factors influencing release kinetics J. Controlled Release 1998, 51, 57-71 (Pubitemid 28064645)
44. Lustig, S. R.; Peppas, N. A. Solute and penetrant diffusion in swellable polymers. VII. A free volume-based model with mechanical relaxation J. Appl. Polym. Sci. 1987, 33, 533-549
45. Papadokostaki, K. G.; Polishchuk, A. Ya.; Petrou, J. K. Modeling of solute release from polymeric monoliths subject to linear structural relaxation J. Polym. Sci., Part B: Polym. Phys. 2002, 40, 1171-1188 (Pubitemid 34599457)
46. Liu, S.; Jiang, M.; Ye, I.; Xu, X.; Lu, P.; Dong, J. Biodegradable poly(glycerin citrate) and its application to controlled release of theophylline J. Appl. Polym. Sci. 2012, 124, 3633-36
47. Petropoulos, J. H.; Papadokostaki, K. G.; Amarantos, S. G. A general model for the release of active agents incorporated in swellable polymer matrices J. Polym. Sci., Part B: Polym. Phys. 1992, 30, 717-725
48. Papadokostaki, K. G. Combined experimental and computer simulation study of the kinetics of solute release from a relaxing swellable polymer matrix. II. Release of an osmotically active solute J. Appl. Polym. Sci. 2004, 92, 2468-2479 (Pubitemid 38476120)
49. Yasuda, H.; Lamaze, C. E.; Ikenberry, L. D. Permeability of solutes through hydrated polymer membranes. Part I. Diffusion of sodium chloride Macromol. Chem. 1968, 118, 19-35
50. Soulas, D. N.; Sanopoulou, M.; Papadokostaki, K. G. Performance of three-layer controlled release devices with uniform or non-uniform material properties: Experiment and computer simulation J. Membr. Sci. 2011, 372, 1-10
51. Brayley, S. The chemistry and properties of the medical-grade silicones J. Macromol. Sci., Chem. 1970, A4, 529-544
52. Bao, Y. T.; Samuel, N. K. P.; Pitt, C. G. The prediction of drug solubilities in polymers J. Polym. Sci., Part C: Polym. Lett. 1988, 26, 41-46
53. Yeom, C. K.; Kim, B. S.; Lee, J. M. Precise on-line measurements of permeation transients through dense polymeric membranes using a new permeation apparatus J. Membr. Sci. 1999, 161, 55-66 (Pubitemid 29308900)
54. Carelli, V.; Di Colo, G. Effect of different water-soluble additives on water sorption into silicone rubber J. Pharm. Sci. 1983, 72, 316-317 (Pubitemid 13159631)
55. Higuchi, T. Rate of release of medicaments from ointment bases containing drugs in suspensions J. Pharm. Sci. 1961, 50, 874-875
56. Siepmann, J.; Peppas, N. A. Higuchi equation: Derivation, applications, use and misuse Int. J. Pharm. 2011, 418, 6-12
57. Barrie, J. A.; Machin, D. The sorption and diffusion of water in silicone rubbers: Part II. Filled rubbers J. Macromol. Sci. Phys. 1969, B3, 673-692
58. Favre, E.; Schaetzel, P.; Nguygen, Q. T.; Clément, R.; Néel, J. Sorption, diffusion and vapor permeation of various penetrants through dense poly(dimethylsiloxane) membranes- A transport analysis J. Membr. Sci. 1994, 92, 169-184
59. Rehula, M.; Di Colo, G. In vitro release of papaverine hydrochloride from silicone polymer matrices containing cross-linked polyethylene glycol-8000 Pharmazie 1993, 48, 42-46 (Pubitemid 23051112)