A model for osmotic pressure driven release from cylindrical rubbery polymer matrices

Journal of Controlled Release

Volumn 93, Issue 3, 2003, Pages 249-258

  Amsden, Brian ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Constant release; Mathematical model; Osmotic pressure; Rubbery polymer

Indexed keywords

CYLINDERS (SHAPES); MATHEMATICAL MODELS; OSMOSIS; RUBBER;

DRUG RELEASE; RUBBERY POLYMER MATRICES;

POLYMERS;

POLYMER; SODIUM IODIDE;

ARTICLE; CONCENTRATION (PARAMETERS); DRUG RELEASE; MATHEMATICAL MODEL; OSMOTIC PRESSURE; PRIORITY JOURNAL; SOLUTE; WATER PERMEABILITY;

EID: 0345303904     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2003.08.007     Document Type: Article

References (23)

1. Carelli V., Di Colo G., Guerrini C., Nannipieri E. Drug release from silicone elastomer through controlled polymer cracking: an extension to macromolecular drugs. Int. J. Pharm. 50(3):1989;181-188.
2. Di Colo G. Controlled drug release from implantable matrices based on hydrophobic polymers. Biomaterials. 13(12):1992;850-856.
3. Gale R., Chandrasekaran S.K., Swanson D., Wright J. Use of osmotically active therapeutic agents in monolithic systems. J. Membr. Sci. 7(3):1980;319-331.
4. Kajihara M., Sugie T., Mizuno M., Tamura N., Sano A., Fujioka K., Kashiwazaki Y., Yamaoka T., Sugawara S., Urabe Y. Development of a new drug delivery system for protein drugs using silicone (I). J. Control. Release. 66:2000;49-61.
5. Kajihara M., Sugie T., Hojo T., Maeda H., Sano A., Fujioka K., Sugawara S., Urabe Y. Development of a new drug delivery system for protein drugs using silicone (II). J. Control. Release. 73:2001;279-291.
6. Wright J., Chandrasekaran S.K., Gale R., Swanson D. Model for the release of osmotically active agents from monolithic polymeric matrices. AIChE Symp. Ser. 77(206):1981.
7. Amsden B.G., Cheng Y.-L., Goosen M.F.A. A mechanistic study of the release of osmotic agents from polymeric monoliths. J. Control. Release. 30(1):1994;45-56.
8. Amsden B., Cheng Y.-L. A generic protein delivery system based on osmotically rupturable monoliths. J. Control. Release. 33:1995;99-105.
9. A.S. Michaels, M.S. Guillod, Osmotic bursting drug delivery device, ALZA: USA patent 4,117,256 (1979).
10. McGinity J.W., Hunke L.A., Combs A.B. Effect of water-soluble carriers on morphine release from a silicone polymer. J. Pharm. Sci. 68(5):1979;662-664.
11. Golomb G., Fisher P., Rahamim E. The relationship between drug release rate, particle size and swelling of silicone matrices. J. Control. Release. 12(2):1990;121-132.
12. Schirrer R., Thepin P., Torres G. Water absorption, swelling, rupture and salt release in salt-silicone rubber compounds. J. Mater. Sci. 27:1992;3424-3434.
13. Fedors R.F. Osmotic effects in water absorption by polymers. Polymer. 21:1980;207-212.
14. Riggs P.D., Kinchesh P., Braden M., Patel M.P. Nuclear magnetic imaging of an osmotic water uptake and delivery process. Biomaterials. 22:2001;419-427.
15. Siegel R., Kost J., Langer R. Mechanistic studies of macromolecular drug release from macroporous polymers. I. Experiments and preliminary theory concerning completeness of drug release. J. Control. Release. 8(3):1989;223-236.
16. Amsden B. Osmotically activated protein release from electrostatically generated polymer microbeads. AIChE J. 42:1996;3253-3266.
17. Torres G. Controlled release of iodine salts from silicone rubber: a solution for iodine disease in developed countries. Proc. Int. Symp. Control. Release Bioact. Mater. 18:1991;403-404.
18. Amsden B.G., Cheng Y.-L. Enhanced fraction releasable above percolation threshold from monoliths containing osmotic excipients. J. Control. Release. 31:1994;21-32.
19. Theeuwes F. Elementary osmotic pump. J. Pharm. Sci. 64(12):1975;1987- 1991.
20. Green A.E., Zerna W. Theoretical Elasticity. 1963;Oxford Univ. Press, Toronto.
21. Hamer W.J., Wu Y.-C. Osmotic coefficients and mean activity coefficients of uni-valent electrolytes in water at 25°C. J. Phys. Chem. Ref. Data. 1(4):1972;1047-1099.
22. Barrie J.A., Machin D. The sorption and diffusion of water in silicone rubbers: Part II. Filled rubbers. J. Macromol. Sci. Phys. B3(4):1969;673-692.
23. Barrie J.A., Machin D. The sorption and diffusion of water in silicone rubbers: Part 1. Unfilled rubbers. J. Macromol. Sci. Phys. B. 3(4):1969;645-672.