Controlled release of a model antibacterial drug from a novel self-lubricating silicone biomaterial

Journal of Controlled Release

Volumn 97, Issue 2, 2004, Pages 313-320

  Malcolm, R K ^a   McCullagh, S D ^a   Woolfson, A D ^a   Gorman, S P ^a   Jones, D S ^a   Cuddy, J ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

Author keywords

Cross linker; Elastomer; Metronidazole; Oleyl alcohol; Silicone

Indexed keywords

BACTERIA; BIOMATERIALS; CONTROLLED DRUG DELIVERY; ELASTOMERS; MEDICAL PROBLEMS; SILICONES;

ANTIBACTERIAL DRUGS; DEVICE-RELATED INFECTION;

DRUG PRODUCTS;

ANTIINFECTIVE AGENT; BIOMATERIAL; ELASTOMER; LUBRICATING AGENT; METRONIDAZOLE; SILANE DERIVATIVE; SILICONE; TETRAOLEYLOXYSILANE; TETRAPROPOXYSILANE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL COMPOSITION; CROSS LINKING; DRUG RELEASE; DRUG SCREENING; DRUG SOLUBILITY; IN VITRO STUDY; LUBRICATION; PRIORITY JOURNAL;

ANTI-BACTERIAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CROSS-LINKING REAGENTS; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; DRUG COMPOUNDING; EXCIPIENTS; FATTY ALCOHOLS; KINETICS; METRONIDAZOLE; SILANES; SILICONE ELASTOMERS; SOLUBILITY;

EID: 2942551434     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.03.029     Document Type: Article

References (20)

1. Yoda R. Elastomers for biomedical applications. J. Biomater. Sci., Polym. Ed. 9:1998;561-626
2. Marion-Ferey K., Pasmore M., Stoodley P., Wilson S., Husson G.P., Costerton J.W. Biofilm removal from silicone tubing: an assessment of the efficacy of dialysis machine decontamination procedures using an in vitro model. J. Hosp. Infect. 53:2003;64-71
3. Cox A.J., Hukins D.W.L. Morphology of mineral-deposits on encrusted urinary catheters investigated by scanning electron-microscopy. J. Urol. 142:1989;1347-1350
4. Bibby J.M., Cox A.J., Hukins D.W.L. Feasibility of preventing encrustation of urinary catheters. Cell. Mater. 5:1995;183-195
5. Tunney M.M., Keane P.F., Gorman S.P. Assessment of urinary tract biomaterial encrustation using a modified robbins device continuous flow model. J. Biomed. Mater. Res. 38:1997;87-93
6. Jones D.S., Garvin C.P., Gorman S.P. Design of a simulated urethra model for the quantitative assessment of urinary catheter lubricity. J. Mater. Sci. Mater. Med. 12:2001;15-21
7. Khoury A.E., Olson M.E., Villari F., Costerton J.W. Determination of the coefficient of kinetic friction of urinary catheter materials. J. Urol. 145:1991;610-612
8. Woolfson A.D., Malcolm R.K., Gorman S.P., Jones D.S., Brown A.F., McCullagh S.D. Self-lubricating silicone elastomer biomaterials. J. Mater. Chem. 13:2003;2465-2470
9. Van der Weij F.W. The action of tin-compounds in condensation-type RTV silicone rubbers. Macromol. Chem. Phys. 181:1980;2541-2548
10. McCullagh S.D., Malcolm R.K., Woolfson A.D., Gorman S.P., Jones D.S., Cuddy J. Release kinetics of oleyl alcohol from a self-lubricating silicone biomaterial. J. Mater. Chem. 14:2004;1093-1098
11. Russell J.A., Malcolm R.K., Campbell K., Woolfson A.D. High performance liquid chromatographic determination of 17β-estradiol and 17β-estradiol-3-acetate solubilities and diffusion coefficients in silicone elastomeric intravaginal rings. J. Chromat. B. 744:2000;157-163
12. Woolfson A.D., Elliot G.R.E., Gilligan C.A., Passmore C.M. Design of an intravaginal ring for the controlled delivery of 17β-estradiol as its 3-acetate ester. J. Control. Rel. 61:1999;319-328
13. Malcolm R.K., Woolfson A.D., Russell J.A., Tallon P., McAuley L., Craig D. Influence of silicone elastomer solubility and diffusivity on the in vitro release of drugs from intravaginal rings. J. Control. Rel. 90:2003;217-225
14. Woolfson A.D., Malcolm R.K., Gallagher R.J. Design of a silicone reservoir intravaginal ring for the delivery of oxybutynin. J. Control. Rel. 91:2003;465-476
15. Malcolm R.K., Woolfson A.D., Russell J.A., Andrews C. In vitro release of nonoxynol-9 from silicone matrix intravaginal rings. J. Control. Rel. 91:2003;355-364
16. Malcolm R.K., McCullagh S.D., Woolfson A.D., Catney M., Tallon P. A dynamic mechanical method for determining the silicone elastomer solubility of drugs and pharmaceutical excipients in silicone intravaginal drug delivery rings. Biomaterials. 23:2002;3589-3594
17. Higuchi W.I., Higuchi T. Theoretical analysis of diffusional movement through heterogeneous barriers. J. Am. Pharm. Assoc. Sci. Ed. 49:1960;598-606
18. Woolfson A.D., Malcolm R.K., Gallagher R. Drug delivery by the intravaginal route. Crit. Rev. Ther. Drug Carr. Syst. 17:2000;509-555
19. Malcolm R.K. The intravaginal ring. Rathbone M.J., Hadgraft J., Roberts M.S. Modified-Release Drug Delivery Technology. 2003;775-790 Marcel Dekker
20. Chien Y.W. Novel Drug Delivery Systems. 2nd ed. Drugs and the Pharmaceutical Sciences. vol. 50:1992;43-137 Marcel Dekker, New York