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Volumn 7, Issue 1, 2012, Pages

Absence of amyloid β oligomers at the postsynapse and regulated synaptic Zn2+in cognitively intact aged individuals with Alzheimer's disease neuropathology

Author keywords

Alzheimer's disease; Asymptomatic; A oligomers; Hippocampus; Synaptic vesicle; Zinc

Indexed keywords

AMYLOID BETA PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GRAPHITE; OLIGOMER; ZINC;

EID: 84861428833     PISSN: None     EISSN: 17501326     Source Type: Journal    
DOI: 10.1186/1750-1326-7-23     Document Type: Article
Times cited : (74)

References (67)
  • 1
    • 84861502237 scopus 로고    scopus 로고
    • Alzheimer's disease facts and figures
    • Alzheimer's A
    • Alzheimer's A: Alzheimer's disease facts and figures. Alzheimer's & Dementia 2010, 2010:6.
    • (2010) Alzheimer's & Dementia 2010 , pp. 6
  • 2
    • 0025899041 scopus 로고
    • Amyloid deposition as the central event in the etiology of Alzheimer's disease
    • Hardy J, Allsop D: Amyloid deposition as the central event in the etiology of Alzheimer's disease. Trends Pharmacol Sci 1991, 12:383-388.
    • (1991) Trends Pharmacol Sci , vol.12 , pp. 383-388
    • Hardy, J.1    Allsop, D.2
  • 3
    • 0025863618 scopus 로고
    • Neuropathological stageing of Alzheimer-related changes
    • Braak H, Braak E: Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991, 82:239-259.
    • (1991) Acta Neuropathol , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 12
    • 56849091064 scopus 로고    scopus 로고
    • Selective induction of calcineurin activity and signaling by oligomeric amyloid beta
    • DOI 10.1111/j.1474-9726.2008.00434.x
    • Reese LC, Zhang W, Dineley KT, Kayed R, Taglialatela G: Selective induction of calcineurin activity and signaling by oligomeric amyloid beta. Aging Cell 2008, 7:824-835. (Pubitemid 352749437)
    • (2008) Aging Cell , vol.7 , Issue.6 , pp. 824-835
    • Reese, L.C.1    Zhang, W.R.2    Dineley, K.T.3    Kayed, R.4    Taglialatela, G.5
  • 13
    • 20444496481 scopus 로고    scopus 로고
    • Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers
    • DOI 10.1074/jbc.M500997200
    • Demuro A, Mina E, Kayed R, Milton SC, Parker I, Glabe CG: Calcium Dysregulation and Membrane Disruption as a Ubiquitous Neurotoxic Mechanism of Soluble Amyloid Oligomers. J Biol Chem 2005, 280:17294-17300. (Pubitemid 41389198)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.17 , pp. 17294-17300
    • Demuro, A.1    Mina, E.2    Kayed, R.3    Milton, S.C.4    Parker, I.5    Glabe, C.G.6
  • 15
    • 67249090809 scopus 로고    scopus 로고
    • Intracerebroventricular administration of amyloid β-protein oligomers selectively increases dorsal hippocampal dialysate glutamate levels in the awake rat
    • O'Shea SD, Smith IM, McCabe OM, Cronin MM, Walsh DM, O'Connor WT: Intracerebroventricular administration of amyloid β-protein oligomers selectively increases dorsal hippocampal dialysate glutamate levels in the awake rat. Sensors 2008, 8:7428-7437.
    • (2008) Sensors , vol.8 , pp. 7428-7437
    • O'Shea, S.D.1    Smith, I.M.2    McCabe, O.M.3    Cronin, M.M.4    Walsh, D.M.5    O'Connor, W.T.6
  • 17
    • 33846633336 scopus 로고    scopus 로고
    • Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease
    • DOI 10.1523/JNEUROSCI.3501-06.2007
    • Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, Wood M, Viola KL, Klein WL: Aβ oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. J Neurosci 2007, 27:796-807. (Pubitemid 46174498)
    • (2007) Journal of Neuroscience , vol.27 , Issue.4 , pp. 796-807
    • Lacor, P.N.1    Buniel, M.C.2    Furlow, P.W.3    Clemente, A.S.4    Velasco, P.T.5    Wood, M.6    Viola, K.L.7    Klein, W.L.8
  • 22
    • 15844417346 scopus 로고    scopus 로고
    • Neuronal activity increases the phosphorylation of the transcription factor cAMP response element-binding protein (CREB) in rat hippocampus and cortex
    • DOI 10.1074/jbc.271.24.14214
    • Moore AN, Waxham MN, Dash PK: Neuronal activity increases the phosphorylation of the transcription factor cAMP response element-binding protein (CREB) in rat hippocampus and cortex. J Biol Chem 1996, 271:14214-14220. (Pubitemid 26190319)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.24 , pp. 14214-14220
    • Moore, A.N.1    Neal, W.M.2    Dash, P.K.3
  • 23
    • 65549109871 scopus 로고    scopus 로고
    • A Potential Role for Alterations of Zinc and Zinc Transport Proteins in the Progression of Alzheimer's Disease
    • Lovell MA: A Potential Role for Alterations of Zinc and Zinc Transport Proteins in the Progression of Alzheimer's Disease. J Alzheimer's Dis 2009, 16:471-483.
    • (2009) J Alzheimer's Dis , vol.16 , pp. 471-483
    • Lovell, M.A.1
  • 25
    • 38649112930 scopus 로고    scopus 로고
    • Zinc-amyloid β interactions on a millisecond time-scale stabilize non-fibrillar Alzheimer-related species
    • DOI 10.1021/ja076282l
    • Noy D, Solomonov I, Sinkevich O, Arad T, Kjaer K, Sagi I: Zinc-Amyloid β Interactions on a Millisecond Time-Scale Stabilize Non-fibrillar Alzheimer-Related Species. J Am Chem Soc 2008, 130:1376-1383. (Pubitemid 351171018)
    • (2008) Journal of the American Chemical Society , vol.130 , Issue.4 , pp. 1376-1383
    • Noy, D.1    Solomonov, I.2    Sinkevich, O.3    Arad, T.4    Kjaer, K.5    Sagi, I.6
  • 26
    • 65249093004 scopus 로고    scopus 로고
    • A role for synaptic zinc in activity-dependent Aβ oligomer formation and accumulation at excitatory synapses
    • Deshpande A, Kawai H, Metherate R, Glabe CG, Busciglio J: A role for synaptic zinc in activity-dependent Aβ oligomer formation and accumulation at excitatory synapses. J Neurosci 2009, 29:4004-4015.
    • (2009) J Neurosci , vol.29 , pp. 4004-4015
    • Deshpande, A.1    Kawai, H.2    Metherate, R.3    Glabe, C.G.4    Busciglio, J.5
  • 27
    • 0030804608 scopus 로고    scopus 로고
    • Increased amount of zinc in the hippocampus and amygdala of Alzheimer's diseased brains: A proton-induced X-ray emission spectroscopic analysis of cryostat sections from autopsy material
    • DOI 10.1016/S0165-0270(97)00079-4, PII S0165027097000794
    • Danscher G, Jensen KB, Frederickson CJ, Kemp K, Andreasen A, Juhl S, Stoltenberg M, Ravid R: Increased amount of zinc in the hippocampus and amygdala of Alzheimer's diseased brains: a proton-induced X-ray emission spectroscopic analysis of cryostat sections from autopsy material. J Neurosci Methods 1997, 76:53-59. (Pubitemid 27405086)
    • (1997) Journal of Neuroscience Methods , vol.76 , Issue.1 , pp. 53-59
    • Danscher, G.1    Jensen, K.B.2    Frederickson, C.J.3    Kemp, K.4    Andreasen, A.5    Juhl, S.6    Stoltenberg, M.7    Ravid, R.8
  • 28
    • 0030297178 scopus 로고    scopus 로고
    • Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: Possible relation to oxidative stress
    • DOI 10.1016/S0022-510X(96)00203-1, PII S0022510X96002031
    • Deibel MA, Ehmann WD, Markesbery WR: Copper, iron, and zinc imbalances in severely degenerated brain regions in Alzheimer's disease: Possible relation to oxidative stress. J Neurol Sci 1996, 143:137-142. (Pubitemid 26402800)
    • (1996) Journal of the Neurological Sciences , vol.143 , Issue.1-2 , pp. 137-142
    • Deibel, M.A.1    Ehmann, W.D.2    Markesbery, W.R.3
  • 31
    • 0025768860 scopus 로고
    • The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein
    • Uchida Y, Takio K, Titani K, Ihara Y, Tomonaga M: The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein. Neuron 1991, 7:337-347.
    • (1991) Neuron , vol.7 , pp. 337-347
    • Uchida, Y.1    Takio, K.2    Titani, K.3    Ihara, Y.4    Tomonaga, M.5
  • 32
    • 76149093866 scopus 로고    scopus 로고
    • Cognitive loss in zinc transporter-3 knock-out mice: A phenocopy for the synaptic and memory deficits of Alzheimer's disease?
    • Adlard PA, Parncutt JM, Finkelstein DI, Bush AI: Cognitive loss in zinc transporter-3 knock-out mice: a phenocopy for the synaptic and memory deficits of Alzheimer's disease?. J Neurosci 2010, 30:1631-1636.
    • (2010) J Neurosci , vol.30 , pp. 1631-1636
    • Adlard, P.A.1    Parncutt, J.M.2    Finkelstein, D.I.3    Bush, A.I.4
  • 33
    • 0035831110 scopus 로고    scopus 로고
    • Metallothionein III is reduced in Alzheimer's disease
    • DOI 10.1016/S0006-8993(00)03196-6, PII S0006899300031966
    • Yu WH, Lukiw WJ, Bergeron C, Niznik HB, Fraser PE: Metallothionein III is reduced in Alzheimer's disease. Brain Res 2001, 894:37-45. (Pubitemid 32197596)
    • (2001) Brain Research , vol.894 , Issue.1 , pp. 37-45
    • Yu W.Haung1    Lukiw, W.J.2    Bergeron, C.3    Niznik, H.B.4    Fraser, P.E.5
  • 34
    • 33747723380 scopus 로고    scopus 로고
    • Mammalian zinc transport, trafficking, and signals
    • DOI 10.1074/jbc.R600011200
    • Cousins RJ, Liuzzi JP, Lichten LA: Mammalian zinc transport, trafficking, and signals. J Biol Chem 2006, 281:24085-24089. (Pubitemid 44274182)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.34 , pp. 24085-24089
    • Cousins, R.J.1    Liuzzi, J.P.2    Lichten, L.A.3
  • 35
    • 0021287299 scopus 로고
    • 2+ from brain tissue during activity
    • Assaf SY, Chung SH: Release of endogenous Zn2+ from brain tissue during activity. Nature 1984, 308:734-736. (Pubitemid 14127670)
    • (1984) Nature , vol.308 , Issue.5961 , pp. 734-736
    • Assaf, S.Y.1    Chung, S.H.2
  • 36
    • 0034091981 scopus 로고    scopus 로고
    • Zinc transport in the brain: Routes of zinc influx and efflux in neurons
    • Colvin RA, Davis N, Nipper RW, Carter PA: Zinc transport in the brain: routes of zinc influx and efflux in neurons. J Nutr 2000, 130:1484S-1487S. (Pubitemid 30244149)
    • (2000) Journal of Nutrition , vol.130 , Issue.5 SUPPL.
    • Colvin, R.A.1    Davis, N.2    Nipper, R.W.3    Carter, P.A.4
  • 38
    • 0028170444 scopus 로고
    • Zn2+: An endogenous modulator of ligand- and voltage-gated ion channels
    • Harrison NL, Gibbons SJ: Zn2+: an endogenous modulator of ligand- and voltage-gated ion channels. Neuropharmacology 1994, 33:935-952.
    • (1994) Neuropharmacology , vol.33 , pp. 935-952
    • Harrison, N.L.1    Gibbons, S.J.2
  • 39
    • 33746379873 scopus 로고    scopus 로고
    • Zinc and copper: Pharmacological probes and endogenous modulators of neuronal excitability
    • DOI 10.1016/j.pharmthera.2005.11.004, PII S0163725805002664
    • Mathie A, Sutton GL, Clarke CE, Veale EL: Zinc and copper: pharmacological probes and endogenous modulators of neuronal excitability. Pharmacol Ther 2006, 111:567-583. (Pubitemid 44118429)
    • (2006) Pharmacology and Therapeutics , vol.111 , Issue.3 , pp. 567-583
    • Mathie, A.1    Sutton, G.L.2    Clarke, C.E.3    Veale, E.L.4
  • 40
    • 0035827681 scopus 로고    scopus 로고
    • Alzheimer's disease amyloid-β binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits
    • Curtain CC, Ali F, Volitakis I, Cherny RA, Norton RS, Beyreuther K, Barrow CJ, Masters CL, Bush AI, Barnham KJ: Alzheimer's disease amyloid-β binds copper and zinc to generate an allosterically ordered membrane-penetrating structure containing superoxide dismutase-like subunits. J Biol Chem 2001, 276:20466-20473.
    • (2001) J Biol Chem , vol.276 , pp. 20466-20473
    • Curtain, C.C.1    Ali, F.2    Volitakis, I.3    Cherny, R.A.4    Norton, R.S.5    Beyreuther, K.6    Barrow, C.J.7    Masters, C.L.8    Bush, A.I.9    Barnham, K.J.10
  • 41
    • 16844373633 scopus 로고    scopus 로고
    • 2+ binding site in amyloid-β
    • DOI 10.1021/bi047611e
    • Karr JW, Akintoye H, Kaupp LJ, Szalai VA: N-Terminal Deletions Modify the Cu2+ Binding Site in Amyloid-β. Biochemistry 2005, 44:5478-5487. (Pubitemid 40489987)
    • (2005) Biochemistry , vol.44 , Issue.14 , pp. 5478-5487
    • Karr, J.W.1    Akintoye, H.2    Kaupp, L.J.3    Szalai, V.A.4
  • 42
    • 0033587478 scopus 로고    scopus 로고
    • Histidine-13 Is a Crucial Residue in the Zinc Ion-Induced Aggregation of the Aβ Peptide of Alzheimer's Disease
    • Liu S-T, Howlett G, Barrow CJ: Histidine-13 Is a Crucial Residue in the Zinc Ion-Induced Aggregation of the Aβ Peptide of Alzheimer's Disease. Biochemistry 1999, 38:9373-9378.
    • (1999) Biochemistry , vol.38 , pp. 9373-9378
    • Liu, S.-T.1    Howlett, G.2    Barrow, C.J.3
  • 43
    • 36749100841 scopus 로고    scopus 로고
    • Investigations of the Molecular Mechanism of Metal-Induced Aβ (1-40) Amyloidogenesis
    • Lim KH, Kim YK, Chang Y-T: Investigations of the Molecular Mechanism of Metal-Induced Aβ (1-40) Amyloidogenesis. Biochemistry 2007, 46:13523-13532.
    • (2007) Biochemistry , vol.46 , pp. 13523-13532
    • Lim, K.H.1    Kim, Y.K.2    Chang, Y.-T.3
  • 46
    • 0033981060 scopus 로고    scopus 로고
    • The Oregon brain aging study: Neuropathology accompanying healthy aging in the oldest old
    • Green MS, Kaye JA, Ball MJ: The Oregon brain aging study: neuropathology accompanying healthy aging in the oldest old. Neurology 2000, 54:105-113. (Pubitemid 30038746)
    • (2000) Neurology , vol.54 , Issue.1 , pp. 105-113
    • Green, M.S.1    Kaye, J.A.2    Ball, M.J.3
  • 49
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's Disease Is a Synaptic Failure
    • Selkoe DJ: Alzheimer's Disease Is a Synaptic Failure. Science 2002, 298:789-791.
    • (2002) Science , vol.298 , pp. 789-791
    • Selkoe, D.J.1
  • 53
    • 0043037252 scopus 로고    scopus 로고
    • 2+/CREB/CBP-dependent gene regulation: A shared mechanism critical in long-term synaptic plasticity and neuronal survival
    • DOI 10.1016/S0143-4160(03)00140-4
    • Bito H, Takemoto-Kimura S: Ca2+/CREB/CBP-dependent gene regulation: a shared mechanism critical in long-term synaptic plasticity and neuronal survival. Cell Calcium 2003, 34:425-430. (Pubitemid 37021234)
    • (2003) Cell Calcium , vol.34 , Issue.4-5 , pp. 425-430
    • Bito, H.1    Takemoto-Kimura, S.2
  • 56
    • 33645505550 scopus 로고    scopus 로고
    • Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: A potent role for trimers
    • Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ: Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. J Physiol 2006, 572: 477-492.
    • (2006) J Physiol , vol.572 , pp. 477-492
    • Townsend, M.1    Shankar, G.M.2    Mehta, T.3    Walsh, D.M.4    Selkoe, D.J.5
  • 59
    • 0033986037 scopus 로고    scopus 로고
    • Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains
    • DOI 10.1016/S0006-8993(99)02096-X, PII S000689939902096X
    • Suh SW, Jensen KB, Jensen MS, Silva DS, Kesslak PJ, Danscher G, Frederickson CJ: Histochemically-reactive zinc in amyloid plaques, angiopathy, and degenerating neurons of Alzheimer's diseased brains. Brain Res 2000, 852:274-278. (Pubitemid 30035163)
    • (2000) Brain Research , vol.852 , Issue.2 , pp. 274-278
    • Suh, S.W.1    Jensen, K.B.2    Jensen, M.S.3    Silva, D.S.4    Kesslak, P.J.5    Danscher, G.6    Frederickson, C.J.7
  • 60
    • 0025908356 scopus 로고
    • The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
    • Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L: The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991, 41:479-486.
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6    Vogel, F.S.7    Hughes, J.P.8    Van Belle, G.9    Berg, L.10
  • 61
    • 0016823810 scopus 로고
    • "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician
    • Folstein MF, Folstein SE, McHugh PR: "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975, 12:189-198.
    • (1975) J Psychiatr Res , vol.12 , pp. 189-198
    • Folstein, M.F.1    Folstein, S.E.2    McHugh, P.R.3
  • 62
    • 0032920274 scopus 로고    scopus 로고
    • Double immunolabeling of neuropeptides in the human hypothalamus as analyzed by confocal laser scanning fluorescence microscopy
    • Romijn HJ, van Uum JF, Breedijk I, Emmering J, Radu I, Pool CW: Double immunolabeling of neuropeptides in the human hypothalamus as analyzed by confocal laser scanning fluorescence microscopy. J Histochem Cytochem 1999, 47:229-236.
    • (1999) J Histochem Cytochem , vol.47 , pp. 229-236
    • Romijn, H.J.1    Van Uum, J.F.2    Breedijk, I.3    Emmering, J.4    Radu, I.5    Pool, C.W.6
  • 63
    • 81555204363 scopus 로고    scopus 로고
    • Selective, quantitative measurement of releasable synaptic zinc in human autopsy hippocampal brain tissue from Alzheimer's disease patients
    • Bjorklund NL, Sadagoparamanujam VM, Taglialatela G: Selective, quantitative measurement of releasable synaptic zinc in human autopsy hippocampal brain tissue from Alzheimer's disease patients. J Neurosci Methods 2012, 203:146-151.
    • (2012) J Neurosci Methods , vol.203 , pp. 146-151
    • Bjorklund, N.L.1    Sadagoparamanujam, V.M.2    Taglialatela, G.3
  • 64
    • 77950632324 scopus 로고    scopus 로고
    • Aβ promotes Alzheimer's disease-like cytoskeleton abnormalities with consequences to APP processing in neurons
    • Henriques AG, Vieira SI, da Cruz E Silva EF, da Cruz E Silva OA: Aβ promotes Alzheimer's disease-like cytoskeleton abnormalities with consequences to APP processing in neurons. J Neurochem 2010, 113:761-771.
    • (2010) J Neurochem , vol.113 , pp. 761-771
    • Henriques, A.G.1    Vieira, S.I.2    Da Cruz, E.3    Silva, E.F.4    Da Cruz, E.5    Silva, O.A.6
  • 65
    • 18144406844 scopus 로고    scopus 로고
    • Proteomic analysis of neurofibrillary tangles in Alzheimer disease identifies GAPDH as a detergent-insoluble paired helical filament tau binding protein
    • 810.1096/fj.1004-3210fje
    • Wang Q, Woltjer RL, Cimino PJ, Pan C, Montine KS, Zhang J, Montine TJ: Proteomic analysis of neurofibrillary tangles in Alzheimer disease identifies GAPDH as a detergent-insoluble paired helical filament tau binding protein. FASEB J 2005, 19:869-871. 810.1096/fj.1004-3210fje.
    • (2005) FASEB J , vol.19 , pp. 869-871
    • Wang, Q.1    Woltjer, R.L.2    Cimino, P.J.3    Pan, C.4    Montine, K.S.5    Zhang, J.6    Montine, T.J.7
  • 66
    • 46249108210 scopus 로고    scopus 로고
    • The use of total protein stains as loading controls: An alternative to high-abundance single-protein controls in semi-quantitative immunoblotting
    • Aldridge GM, Podrebarac DM, Greenough WT, Weiler IJ: The use of total protein stains as loading controls: An alternative to high-abundance single-protein controls in semi-quantitative immunoblotting. J Neurosci Methods 2008, 172:250-254.
    • (2008) J Neurosci Methods , vol.172 , pp. 250-254
    • Aldridge, G.M.1    Podrebarac, D.M.2    Greenough, W.T.3    Weiler, I.J.4
  • 67
    • 51249172857 scopus 로고
    • A hydrogen-peroxide digestion system for tissue trace-metal analysis
    • Alcock NW: A hydrogen-peroxide digestion system for tissue trace-metal analysis. Biol Trace Elem Res 1987, 13:363-370.
    • (1987) Biol Trace Elem Res , vol.13 , pp. 363-370
    • Alcock, N.W.1


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