-
1
-
-
85056533764
-
High-throughput strategies for in vitro ADME assays: How fast can we go
-
Korfmacher WA (Ed.). CRC Press, Boca Raton, FL, USA
-
Kassel DB. High-throughput strategies for in vitro ADME assays: how fast can we go ? In: Using Mass Spectrometry for Drug Metabolism Studies. Korfmacher WA (Ed.). CRC Press, Boca Raton, FL, USA, 83-102 (2005).
-
(2005)
Using Mass Spectrometry for Drug Metabolism Studies
, pp. 83-102
-
-
Kassel, D.B.1
-
2
-
-
62549133279
-
-
Ackermann BL, Berna MJ, Eckstein JA, Ott LW, Chaudhary AK. Current applications of liquid chromatography/mass spectrometry in pharmaceutical discovery after a decade of innovation. Annu. Rev. Anal. Chem. 1, 357-396 (2008).
-
(2008)
Current applications of liquid chromatography/mass spectrometry in pharmaceutical discovery after a decade of innovation. Annu. Rev. Anal. Chem.
, vol.1
, pp. 357-396
-
-
Ackermann, B.L.1
Berna, M.J.2
Eckstein, J.A.3
Ott, L.W.4
Chaudhary, A.K.5
-
3
-
-
0038387389
-
A guide to drug discovery: hit and lead generation: Beyond high-throughput screening
-
Bleicher KH, Boehm H-J, Mueller K, Alanine AI. A guide to drug discovery: hit and lead generation: Beyond high-throughput screening. Nat. Rev. Drug Discov. 2(5), 369-378 (2003).
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, Issue.5
, pp. 369-378
-
-
Bleicher, K.H.1
Boehm, H.-J.2
Mueller, K.3
Alanine, A.I.4
-
4
-
-
69249149274
-
Drug-like property concepts in pharmaceutical design
-
Di L, Kerns EH, Carter GT, Drug-like property concepts in pharmaceutical design. Curr. Pharm. Des. 15(19), 2184-2194 (2009).
-
(2009)
Curr. Pharm. Des.
, vol.15
, Issue.19
, pp. 2184-2194
-
-
Di L Kerns, E.H.1
Carter, G.T.2
-
5
-
-
60749117886
-
High throughput ADME screening: Practical considerations, impact on the portfolio and enabler of in silico ADME models
-
Hop, CE, Cole MJ, Davidson RE et al. High throughput ADME screening: Practical considerations, impact on the portfolio and enabler of in silico ADME models. Curr. Drug Metab. 9(9), 847-853 (2008).
-
(2008)
Curr. Drug Metab.
, vol.9
, Issue.9
, pp. 847-853
-
-
Hop, C.E.1
Cole, M.J.2
Davidson, R.E.3
-
6
-
-
80053471789
-
The influence of the 'organizational factor' on compound quality in drug discovery
-
Leeson PD, St Gallay SA. The influence of the 'organizational factor' on compound quality in drug discovery. Nat. Rev. Drug Disc. 10(10), 749-765 (2011).
-
(2011)
Nat. Rev. Drug Disc.
, vol.10
, Issue.10
, pp. 749-765
-
-
Leeson, P.D.1
St Gallay, S.A.2
-
7
-
-
84861356283
-
In vitro ADME profiling and pharmacokinetic screening in drug discovery
-
(2nd Edition). Cole RB (Ed.). John Wiley & Sons, Inc., NJ, USA
-
Kassel DB. In vitro ADME profiling and pharmacokinetic screening in drug discovery. In: Electrospray and MALDI Mass Spectrometry: Fundamentals, Instrumentation, Practicalities, and Biological Applications (2nd Edition). Cole RB (Ed.). John Wiley & Sons, Inc., NJ, USA, 799-824 (2010).
-
(2010)
Electrospray and MALDI Mass Spectrometry: Fundamentals, Instrumentation, Practicalities, and Biological Applications
, pp. 799-824
-
-
Kassel, D.B.1
-
8
-
-
24644432436
-
Characterization and performance of MALDI on a triple quadrupole mass spectrometer for analysis and quantification of small molecules
-
Gobey J, Cole M, Janiszewski J et al. Characterization and performance of MALDI on a triple quadrupole mass spectrometer for analysis and quantification of small molecules. Anal. Chem. 77(17), 5643-5654 (2005).
-
(2005)
Anal. Chem.
, vol.77
, Issue.17
, pp. 5643-5654
-
-
Gobey, J.1
Cole, M.2
Janiszewski, J.3
-
9
-
-
79951670807
-
Desorption ionization techniques for quantitative analysis of drug molecules
-
Pharmacokinet. Ramanathan R (Ed.). John Wiley & Sons, Inc., NJ, USA
-
Gobey JS, Janiszewski J, Cole MJ. Desorption ionization techniques for quantitative analysis of drug molecules. In: Mass Spectrom. Drug Metab. Pharmacokinet. Ramanathan R (Ed.). John Wiley & Sons, Inc., NJ, USA, 341-358 (2009).
-
(2009)
Mass Spectrom. Drug Metab
, pp. 341-358
-
-
Gobey, J.S.1
Janiszewski, J.2
Cole, M.J.3
-
10
-
-
0036001224
-
High-speed gradient parallel liquid chromatography- tandem mass spectrometry with fully automated sample preparation for bioanalysis: 30 seconds per sample from plasma
-
Deng Y, Wu J-T, Lloyd TL et al. High-speed gradient parallel liquid chromatography- tandem mass spectrometry with fully automated sample preparation for bioanalysis: 30 seconds per sample from plasma. Rapid Commun. Mass Spectrom. 16(11), 1116-1123 (2002).
-
(2002)
Rapid. Commun. Mass Spectrom.
, vol.16
, Issue.11
, pp. 1116-1123
-
-
Deng, Y.1
Wu, J.-T.2
Lloyd, T.L.3
-
11
-
-
84861370740
-
Ultra-high throughput quantitative analysis using medusa parallel sprayer
-
Presented at. Nashville, TN, USArftxt 23-27 May
-
Gibson D, Saunders K. Ultra-high throughput quantitative analysis using medusa parallel sprayer. Presented at: The 52nd American Society of Mass Spectrometry Conference. Nashville, TN, USA, 23-27 May 2004.
-
(2004)
52nd American Society of Mass Spectrometry Conference
-
-
Gibson, D.1
Saunders, K.2
-
12
-
-
80052729080
-
High-throughput , 384-well, LC-MS/MS CYP inhibition assay using automation , cassette-analysis technique and streamlined data analysis
-
Halladay JS, Delarosa EM, Tran D, Wang L, Wong S, Khojasteh SC. High-throughput , 384-well, LC-MS/MS CYP inhibition assay using automation , cassette-analysis technique and streamlined data analysis. Drug Metab. Lett. 5(3), 220-230 (2011).
-
(2011)
Drug Metab. Lett.
, vol.5
, Issue.3
, pp. 220-230
-
-
Halladay, J.S.1
Delarosa, E.M.2
Tran, D.3
Wang, L.4
Wong, S.5
Khojasteh, S.C.6
-
13
-
-
75949109352
-
A high throughput metabolic stability screening workflow with automated assessment of data quality in pharmaceutical industry
-
Xu R, Manuel, M, Cramlett J, Kassel DB. A high throughput metabolic stability screening workflow with automated assessment of data quality in pharmaceutical industry. J. Chromatogr. A 1217(10), 1616-1625 (2010).
-
(2010)
J. Chromatogr.
, vol.A1217
, Issue.10
, pp. 1616-1625
-
-
Xu, R.1
Manuel, M.2
Cramlett, J.3
Kassel, D.B.4
-
14
-
-
84880193008
-
Improving the throughput of in vitro ADME screens using cassette analysis and polarity switching
-
Presented at. Salt Lake City, UT, USA 23-27 May
-
Zhang H, Zelesky V, Schneider R et al. Improving the throughput of in vitro ADME screens using cassette analysis and polarity switching. Presented at: The 58th American Society of Mass Spectrometry Conference. Salt Lake City, UT, USA, 23-27 May 2010.
-
(2010)
58th American Society of Mass Spectrometry Conference
-
-
Zhang, H.1
Zelesky, V.2
Schneider, R.3
-
15
-
-
78449308285
-
An integrated bioanalytical platform for supporting high-throughput serum protein binding screening
-
Zhang J, Shou WZ, Vath M, Kieltyka, K et al. An integrated bioanalytical platform for supporting high-throughput serum protein binding screening. Rapid Commun. Mass Spectrom. 24(24), 3593-3601 (2010).
-
(2010)
Rapid. Commun. Mass Spectrom.
, vol.24
, Issue.24
, pp. 3593-3601
-
-
Zhang, J.1
Shou, W.Z.2
Vath, M.3
Kieltyka, K.4
-
16
-
-
60749103325
-
Perspectives on bioanalytical mass spectrometry and automation in drug discovery
-
Janiszewski JS, Liston TE, Cole M J. Perspectives on bioanalytical mass spectrometry and automation in drug discovery. Curr. Drug Metab. 9(9), 986-994 (2008).
-
(2008)
Curr. Drug Metab.
, vol.9
, Issue.9
, pp. 986-994
-
-
Janiszewski, J.S.1
Liston, T.E.2
Cole M, J.3
-
17
-
-
77957752877
-
An integrated platform for fully automated high-throughput LC-MS/ MS analysis of in vitro metabolic stability assay samples
-
Luippold AH, Arnhold T, Joerg W, Suessmuth RD. An integrated platform for fully automated high-throughput LC-MS/ MS analysis of in vitro metabolic stability assay samples. Int. J. Mass Spectrom. 296(1-3), 1-9 (2010).
-
(2010)
Int. J. Mass Spectrom.
, vol.296
, Issue.1-3
, pp. 1-9
-
-
Luippold, A.H.1
Arnhold, T.2
Joerg, W.3
Suessmuth, R.D.4
-
18
-
-
79954595020
-
Application of a rapid and integrated analysis system (RIAS) as a high-throughput processing tool for in vitro ADME samples by liquid chromatography/ tandem mass spectrometry
-
Luippold AH, Arnhold T, Joerg W, Krueger B, Suessmuth RD. Application of a Rapid and Integrated Analysis System (RIAS) as a high-throughput processing tool for in vitro ADME samples by liquid chromatography/ tandem mass spectrometry. J. Biomol. Screen. 16(3), 370-377 (2011).
-
(2011)
J. Biomol. Screen.
, vol.16
, Issue.3
, pp. 370-377
-
-
Luippold, A.H.1
Arnhold, T.2
Joerg, W.3
Krueger, B.4
Suessmuth, R.D.5
-
19
-
-
80155167738
-
Evaluation of a high-throughput online solid phase extraction-tandem mass spectrometry system for in vivo bioanalytical studies
-
Jian W, Romm MV, Edom RW, Miller VP, LaMarr WA, Weng N. Evaluation of a high-throughput online solid phase extraction-tandem mass spectrometry system for in vivo bioanalytical studies. Anal. Chem. 83(21), 8259-8266 (2011).
-
(2011)
Anal. Chem.
, vol.83
, Issue.21
, pp. 8259-8266
-
-
Jian, W.1
Romm, M.V.2
Edom, R.W.3
Miller, V.P.4
LaMarr, W.A.5
Weng, N.6
-
20
-
-
77955507698
-
A review of LC-MS techniques and high-throughput approaches used to investigate drug metabolism by cytochrome P450s
-
Youdim KA, Saunders KC. A review of LC-MS techniques and high-throughput approaches used to investigate drug metabolism by cytochrome P450s. J. Chromatogr. B 878(17-18), 1326-1336 (2010).
-
(2010)
J. Chromatogr.
, vol.B878
, Issue.17-18
, pp. 1326-1336
-
-
Youdim, K.A.1
Saunders, K.C.2
-
21
-
-
77249141191
-
Recent development in high-throughput bioanalytical support for in vitro ADMET profiling
-
Shou WZ, Zhang J. Recent development in high-throughput bioanalytical support for in vitro ADMET profiling. Expert Opin. Drug Metab. Tox. 6(3), 321-336 (2010).
-
(2010)
Expert Opin. Drug Metab. Tox.
, vol.6
, Issue.3
, pp. 321-336
-
-
Shou, W.Z.1
Zhang, J.2
-
22
-
-
33646745530
-
A centralized approach to tandem mass spectrometry method development for high-throughput ADME screening
-
Whalen K, Gobey J, Janiszewski J. A centralized approach to tandem mass spectrometry method development for high-throughput ADME screening. Rapid Commun. Mass Spectrom. 20(10), 1497-1503 (2006).
-
(2006)
Rapid. Commun. Mass Spectrom.
, vol.20
, Issue.10
, pp. 1497-1503
-
-
Whalen, K.1
Gobey, J.2
Janiszewski, J.3
-
23
-
-
0036671008
-
Optimizing higher throughput methods to assess drug-drug interactions for CYP1A2, CYP2C9, CYP2D6, rCYP2D6 and CYP3A4 in vitro using a single point IC50
-
Gao F, Johnson DL, Ekins S et al. Optimizing higher throughput methods to assess drug-drug interactions for CYP1A2, CYP2C9, CYP2D6, rCYP2D6 and CYP3A4 in vitro using a single point IC50. J. Biomol. Screen. 7(4), 373-382 (2002).
-
(2002)
J. Biomol. Screen.
, vol.7
, Issue.4
, pp. 373-382
-
-
Gao, F.1
Johnson, D.L.2
Ekins, S.3
-
24
-
-
79551633386
-
An in vitro, high throughput , seven CYP cocktail inhibition assay for the evaluation of new chemical entities using LC-MS/MS
-
Otten JN, Hingorani GP, Hartley DP, Kragerud SD, Franklin RB. An in vitro, high throughput , seven CYP cocktail inhibition assay for the evaluation of new chemical entities using LC-MS/MS. Drug Metab. Lett. 5(1), 17-24 (2011).
-
(2011)
Drug Metab. Lett.
, vol.5
, Issue.1
, pp. 17-24
-
-
Otten, J.N.1
Hingorani, G.P.2
Hartley, D.P.3
Kragerud, S.D.4
Franklin, R.B.5
-
25
-
-
34247261031
-
Analytical approaches to determine cytochrome P450 inhibitory potential of new chemical entities in drug discovery
-
Smith D, Sadagopan N, Zientek M, Reddy A, Cohen L. Analytical approaches to determine cytochrome P450 inhibitory potential of new chemical entities in drug discovery. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 850(1-2), 455-463 (2007).
-
(2007)
J. Chromatogr. B Analyt. Technol. Biomed. Life Sci.
, vol.850
, Issue.1-2
, pp. 455-463
-
-
Smith, D.1
Sadagopan, N.2
Zientek, M.3
Reddy, A.4
Cohen, L.5
-
26
-
-
55549132252
-
Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds
-
Zientek M, Miller H, Smith D, Dunklee MB et al. Development of an in vitro drug-drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds. J. Pharmacol. Toxicol. Methods 58(3), 206-214 (2008).
-
(2008)
J. Pharmacol. Toxicol. Methods
, vol.58
, Issue.3
, pp. 206-214
-
-
Zientek, M.1
Miller, H.2
Smith, D.3
Dunklee, M.B.4
-
27
-
-
49949086869
-
An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point
-
Youdim KA, Lyons R, Payne L, Jones BC, Saunders K. An automated, high-throughput, 384 well Cytochrome P450 cocktail IC50 assay using a rapid resolution LC-MS/MS end-point. J. Pharmaceut. Biomed. Anal. 48(1), 92-99 (2008).
-
(2008)
J. Pharmaceut. Biomed. Anal.
, vol.48
, Issue.1
, pp. 92-99
-
-
Youdim, K.A.1
Lyons, R.2
Payne, L.3
Jones, B.C.4
Saunders, K.5
-
28
-
-
0035298741
-
A high-capacity LC-MS system for the bioanalysis of samples generated from plate-based metabolic screening
-
Janiszewski JS, Rogers K J, Whalen KM et al. A high-capacity LC-MS system for the bioanalysis of samples generated from plate-based metabolic screening. Anal. Chem. 73(7), 1495-1501 (2001).
-
(2001)
Anal. Chem.
, vol.73
, Issue.7
, pp. 1495-1501
-
-
Janiszewski, J.S.1
Rogers, K.J.2
Whalen, K.M.3
-
29
-
-
4544227015
-
An LC-MS/ MS dual column method to support high throughput bioanalysis of in vitro ADME screening samples
-
16
-
Freiwald S, Smith D, Winters R. An LC-MS/ MS dual column method to support high throughput bioanalysis of in vitro ADME screening samples. Am. Pharm. Rev. 7(4), 16, 18-19 (2004).
-
(2004)
Am. Pharm. Rev.
, vol.7
, Issue.4
, pp. 18-19
-
-
Freiwald, S.1
Smith, D.2
Winters, R.3
-
30
-
-
84861370741
-
Improving the success rate of 'trap and elute' chromatography for high-throughput LC- MS/MS bioanalysis
-
Presented at. Philadelphia, PA, USA 1-4 June
-
Zhang H, Janiszewski JS, Schneider RP. Improving the success rate of 'trap and elute' chromatography for high-throughput LC- MS/MS bioanalysis. Presented at: The 57th American Society of Mass Spectrometry Conference. Philadelphia, PA, USA, 1-4 June 2009.
-
(2009)
57th American Society of Mass Spectrometry Conference
-
-
Zhang, H.1
Janiszewski, J.S.2
Schneider, R.P.3
-
31
-
-
84873068369
-
Collaborative methods development in drug discovery
-
Presented at. Denver, CO, USA 5-9 June
-
Miller E, Shirey K, Clouser-Roche A, Zelesky V, Whalen et al. Collaborative methods development in drug discovery. Presented at: The 59th American Society of Mass Spectrometry Conference. Denver, CO, USA, 5-9 June 2011.
-
(2011)
59th American Society of Mass Spectrometry Conference
-
-
Miller, E.1
Shirey, K.2
Clouser-Roche, A.3
Zelesky V, Whalen.4
-
32
-
-
85034652324
-
High throughput LC-MS methods development for in vitro ADME screening
-
Presented at. Denver, CO, USA 5-9 June
-
Zelesky V, Schneider RP, Janiszewski JS, Zhang H. High throughput LC-MS methods development for in vitro ADME screening. Presented at: The 59th American Society of Mass Spectrometry Conference. Denver, CO, USA, 5-9 June 2011.
-
(2011)
59th American Society of Mass Spectrometry Conference
-
-
Zelesky, V.1
Schneider, R.P.2
Janiszewski, J.S.3
Zhang, H.4
|