Application of a Rapid and Integrated Analysis System (RIAS) as a high-throughput processing tool for in vitro ADME samples by liquid chromatography/tandem mass spectrometry

Journal of Biomolecular Screening

Volumn 16, Issue 3, 2011, Pages 370-377

  Luippold, Andreas H ^a   Arnhold, Thomas ^a   Jörg, Wolfgang ^a   Krüger, Beate ^a   Süssmuth, Roderich D ^b  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b TECHNISCHE UNIVERSITÄT BERLIN   (Germany)

Author keywords

active barcoding; high throughput; in vitro ADME; RIAS

Indexed keywords

1 HYDROXYMIDAZOLAM; 2 H 6 DEHYDRONIFEDIPINE; 4 HYDROXYDICLOFENAC; 4 HYDROXYMEPHENYTOIN; AMODIAQUINE; BENZBROMARONE; CYTOCHROME P450; DEXTROMETHORPHAN; DEXTRORPHAN; DICLOFENAC; ERYTHROMYCIN; FLUOXETINE; HYDROXYDICLOFENAC; KETOCONAZOLE; MEPHENYTOIN; MIDAZOLAM; NIFEDIPINE; NORFLUOXETINE; PAROXETINE; SULFAPHENAZOLE; TICLOPIDINE; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; COMPUTER INTERFACE; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG ABSORPTION; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; ELECTROSPRAY; ENZYME INHIBITION; FEASIBILITY STUDY; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PARALLEL ARTIFICIAL MEMBRANE PERMEABILITY ASSAY; PRIORITY JOURNAL; RAPID AND INTEGRATED ANALYSIS SYSTEM; TANDEM MASS SPECTROMETRY; WORKFLOW;

CACO-2 CELLS; CHROMATOGRAPHY, LIQUID; DRUG EVALUATION, PRECLINICAL; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; PHARMACEUTICAL PREPARATIONS; SOFTWARE; SYSTEMS INTEGRATION; TANDEM MASS SPECTROMETRY;

EID: 79954595020     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057110397358     Document Type: Article

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