Evaluation of a high-throughput online solid phase extraction-tandem mass spectrometry system for in vivo bioanalytical studies

Analytical Chemistry

Volumn 83, Issue 21, 2011, Pages 8259-8266

  Jian, Wenying ^a   Romm, Michelle V ^b   Edom, Richard W ^a   Miller, Vaughn P ^b   Lamarr, William A ^b   Weng, Naidong ^a  

^a JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^b Agilent Technologies   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURATE MEASUREMENT; AUTOMATED SYSTEMS; BIOANALYSIS; BIOANALYTICAL; CLINICAL SAMPLES; HIGH-THROUGHPUT; IN-VITRO; IN-VIVO; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; MATRIX; MATRIX EFFECTS; ON-LINE SOLID PHASE EXTRACTION; OPERATING CONDITION; PHASE EXTRACTION; SAMPLE PREPARATION; SOLID-PHASE; SOURCE CONDITIONS; SPECTROMETRY SYSTEMS; STABLE ISOTOPE LABELED INTERNAL STANDARDS; STRUCTURAL ANALOGUE; TANDEM MASS SPECTROMETRY; THERAPEUTIC TARGETS; ULTRA-FAST;

AUTOMATION; ION SOURCES; IONIZATION; ISOTOPES; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; METABOLITES; THROUGHPUT;

EXTRACTION;

DICLOFENAC; FLUOXIDINE; PLASMA PROTEIN; PYRIMIDINE DERIVATIVE;

ANIMAL; ARTICLE; CHEMISTRY; DOG; EVALUATION; HIGH THROUGHPUT SCREENING; HUMAN; LIQUID CHROMATOGRAPHY; ONLINE SYSTEM; RAT; SOLID PHASE EXTRACTION; STANDARD; TANDEM MASS SPECTROMETRY;

ANIMALS; BLOOD PROTEINS; CHROMATOGRAPHY, LIQUID; DICLOFENAC; DOGS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; ONLINE SYSTEMS; PYRIMIDINES; RATS; REFERENCE STANDARDS; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY;

EID: 80155167738     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac202017c     Document Type: Article

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