Molecular mechanism of ATP hydrolysis in F1-ATPase revealed by molecular simulations and single-molecule observations

Journal of the American Chemical Society

Volumn 134, Issue 20, 2012, Pages 8447-8454

  Hayashi, Shigehiko ^a   Ueno, Hiroshi ^b   Shaikh, Abdul Rajjak ^a   Umemura, Myco ^a   Kamiya, Motoshi ^a   Ito, Yuko ^c   Ikeguchi, Mitsunori ^c   Komoriya, Yoshihito ^d   Iino, Ryota ^e   Noji, Hiroyuki ^e  

^a KYOTO UNIVERSITY   (Japan)

^b CHUO UNIVERSITY   (Japan)

^c YOKOHAMA CITY UNIVERSITY   (Japan)

^d OSAKA UNIVERSITY   (Japan)

^e UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ATP HYDROLYSIS; BIOLOGICAL SIGNIFICANCE; BOND DISSOCIATION; CHAIN ACTIVATION; COMPLEX NATURE; ENZYMATIC ACTIVITIES; MOLECULAR MECHANISM; MOLECULAR SIMULATIONS; NUCLEOTIDE TRIPHOSPHATES; PROTEIN FUNCTIONS; RATE-DETERMINING STEP; REACTION MECHANISM; ROTARY MOTOR; SINGLE-MOLECULE OBSERVATION; WATER MOLECULE;

ADENOSINETRIPHOSPHATE; AMINO ACIDS; CATALYSIS; ENZYMATIC HYDROLYSIS; HYDROGEN BONDS; MOLECULAR STRUCTURE; PRINCIPAL COMPONENT ANALYSIS; PROTEINS;

MOLECULES;

ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; ARGININE; MOLECULAR MOTOR; NUCLEOTIDE TRIPHOSPHATE; PHOSPHATE; UNCLASSIFIED DRUG; WATER;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; HYDROGEN BOND; HYDROLYSIS; MOLECULAR MECHANICS; PROTEIN FUNCTION; PROTEIN MOTIF; PROTON TRANSPORT; RATE DETERMINING STEP; SIMULATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CATTLE; HYDROLYSIS; MOLECULAR DYNAMICS SIMULATION; MUTATION; PROTON-TRANSLOCATING ATPASES; THERMODYNAMICS;

EID: 84861404367     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja211027m     Document Type: Article

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