Induced pluripotent stem cell clones reprogrammed via recombinant adeno-associated virus-mediated transduction contain integrated vector sequences

Journal of Virology

Volumn 86, Issue 8, 2012, Pages 4463-4467

  Weltner, J ^a   Anisimov, A ^b   Alitalo, K ^b   Otonkoski, T ^a,b   Trokovic, R ^a  

^a BIOMEDICUM HELSINKI   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

KRUPPEL LIKE FACTOR 4; MYC PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; PARVOVIRUS VECTOR; TRANSCRIPTION FACTOR SOX2;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CLONE; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL STRUCTURE; CELL VIABILITY; DNA INTEGRATION; FIBROBLAST; GENE EXPRESSION; GENE SEQUENCE; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROCESS OPTIMIZATION;

ANIMALS; CELL DIFFERENTIATION; CELL LINE; DEPENDOVIRUS; FIBROBLASTS; GENETIC VECTORS; HUMANS; INDUCED PLURIPOTENT STEM CELLS; MICE; TRANSCRIPTION FACTORS; TRANSDUCTION, GENETIC; VIRUS INTEGRATION;

ADENO-ASSOCIATED VIRUS;

EID: 84861392488     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.06302-11     Document Type: Article

References (36)

1. Bickel JS, et al. 2010. Structural maintenance of chromosomes (SMC) proteins promote homolog-independent recombination repair in meiosis crucial for germ cell genomic stability. PLoS Genet. 6:e1001028.
2. Buecker C, et al. 2010. A murine ESC-like state facilitates transgenesis and homologous recombination in human pluripotent stem cells. Cell Stem Cell 6:535-546.
3. Buning H, Perabo L, Coutelle O, Quadt-Humme S, Hallek M. 2008. Recent developments in adeno-associated virus vector technology. J. Gene Med. 10:717-733.
4. Carter P, Samulski R. 2000. Adeno-associated viral vectors as gene delivery vehicles. Int. J. Mol. Med. 6:17-27.
5. Cervelli T, et al. 2008. Processing of recombinant AAV genomes occurs in specific nuclear structures that overlap with foci of DNA-damageresponse proteins. J. Cell Sci. 121:349-357.
6. Choi VW, McCarty DM, Samulski RJ. 2006. Host cell DNA repair pathways in adeno-associated viral genome processing. J. Virol. 80: 10346-10356.
7. Fusaki N, Ban H, Nishiyama A, Saeki K, Hasegawa M. 2009. Efficient induction of transgene-free human pluripotent stem cells using a vector based on Sendai virus, an RNA virus that does not integrate into the host genome. Proc. Jpn. Acad. Ser. B 85:348-362.
8. Gao G-P, et al. 2002. Novel adeno-associated viruses from rhesus monkeys as vectors for human gene therapy. Proc. Natl. Acad. Sci. U. S. A. 99:11854-11859.
9. Gore A, et al. 2011. Somatic coding mutations in human induced pluripotent stem cells. Nature 471:63-67.
10. Grimm D, Kern A, Rittner K, Kleinschmidt JA. 1998. Novel tools for production and purification of recombinant adenoassociated virus vectors Hum. Gene Ther. 9:2745-2760.
11. Honaramooz A, et al. 2008. Adeno-associated virus (AAV)-mediated transduction of male germ line stem cells results in transgene transmission after germ cell transplantation. FASEB J. 22:374-382.
12. Huangfu D, et al. 2008. Induction of pluripotent stem cells by defined factors is greatly improved by small-molecule compounds. Nat. Biotechnol. 26:795-797.
13. Hussein SM, et al. 2011. Copy number variation and selection during reprogramming to pluripotency. Nature 471:58-62.
14. Inagaki K, et al. 2007. DNA palindromes with a modest arm length of greater, similar 20 base pairs are a significant target for recombinant adeno-associated virus vector integration in the liver, muscles, and heart in mice. J. Virol. 81:11290-11303.
15. Jalkanen J, et al. 2003. Adeno-associated virus-mediated gene transfer of a secreted decoy human macrophage scavenger receptor reduces atherosclerotic lesion formation in LDL receptor knockout mice. Gene Ther. 8:903-910.
16. Laurent LC, et al. 2011. Dynamic changes in the copy number of pluripotency and cell proliferation genes in human ESCs and iPSCs during reprogramming and time in culture. Cell Stem Cell 8:106-118.
17. Lin T, et al. 2009. A chemical platform for improved induction of human iPSCs. Nat. Methods 6:805-808.
18. Mali P, et al. 2010. Butyrate greatly enhances derivation of human induced pluripotent stem cells by promoting epigenetic remodeling and the expression of pluripotency-associated genes. Stem Cells 28:713-720.
19. Miller DG, Petek LM, Russell DW. 2004. Adeno-associated virus vectors integrate at chromosome breakage sites. Nat. Genet. 36:767-773.
20. Nakai H, et al. 2003. AAV serotype 2 vectors preferentially integrate into active genes in mice. Nat. Genet. 34:297-302.
21. Nakai H, et al. 2000. Recruitment of single-stranded recombinant adenoassociated virus vector genomes and intermolecular recombination are responsible for stable transduction of liver in vivo. J. Virol. 74:9451-9463.
22. Nichols J, Smith A. 2009. Naive and primed pluripotent states. Cell Stem Cell 4:487-492.
23. Okita K, Nakagawa M, Hyenjong H, Ichisaka T, Yamanaka S. 2008. Generation of mouse induced pluripotent stem cells without viral vectors. Science 322:949-953.
24. Paterna JC, Moccetti T, Mura Feldon J, Büeler H. 2000. Influence of promoter and WHV post-transcriptional regulatory element on AAVmediated transgene expression in the rat brain. Gene Ther. 7:1304-1311.
25. Penaud-Budloo M, et al. 2008. Adeno-associated virus vector genomes persist as episomal chromatin in primate muscle. J. Virol. 82:7875-7885.
26. Russell DW, Kay MA. 1999. Adeno-associated virus vectors and hematology. Blood 94:864-874.
27. Schwartz RA, et al. 2007. The Mre11/Rad50/Nbs1 complex limits adenoassociated virus transduction and replication. J. Virol. 81:12936-12945.
28. Stadtfeld M, Nagaya M, Utikal J, Weir G, Hochedlinger K. 2008. Induced pluripotent stem cells generated without viral integration. Science 322:945-949.
29. Surosky RT, et al. 1997. Adeno-associated virus Rep proteins target DNA sequences to a unique locus in the human genome. J. Virol. 71:7951-7959.
30. Takahashi K, Yamanaka S. 2006. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676.
31. van Os R, et al. 1999. Recombinant adeno-associated virus-based vectors provide short-term rather than long-term transduction of primitive hematopoietic stem cells. Stem Cells 17:117-120.
32. Warren L, et al. 2010. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7:618-630.
33. Yu J, et al. 2009. Human induced pluripotent stem cells free of vector and transgene sequences. Science 324:797-801.
34. Yu J, et al. 2007. Induced pluripotent stem cell lines derived from human somatic cells. Science 318:1917-1920.
35. Zhou H, et al. 2009. Generation of induced pluripotent stem cells using recombinant proteins. Cell Stem Cell 4:381-384.
36. Zolotukhin S, et al. 1999. Recombinant adeno-associated virus purification using novel methods improves infectious titer and yield. Gene Ther. 6:973-985.