X-ray structures of a designed binding site in trypsin show metal-dependent geometry

Biochemistry

Volumn 35, Issue 19, 1996, Pages 5999-6009

  Brinen, Linda S ^a   Willett, W Scott ^a,b   Craik, Charles S ^b   Fletterick, Robert J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF COLORADO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHYMOTRYPSIN; COPPER; HISTIDINE; IMIDAZOLE; METAL; NICKEL; PANCREAS ENZYME; TRYPSIN; ZINC;

ARTICLE; BINDING SITE; CATALYSIS; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; GEOMETRY; METAL BINDING; NONHUMAN; PRIORITY JOURNAL; X RAY CRYSTALLOGRAPHY;

BACTERIAL PROTEINS; BINDING SITES; CATALYSIS; CATIONS, DIVALENT; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI PROTEINS; MACROMOLECULAR SUBSTANCES; METALS; PERIPLASMIC PROTEINS; SUBSTRATE SPECIFICITY; TRYPSIN;

EID: 0029918132     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9530200     Document Type: Article

References (43)

1. Adman, E. T., & Jenson, L. H. (1981) Isr. J. Chem. 21, 8-12.
2. Adman, E. T., Stenkamp, R. E., Sieker, L. C., & Jensen, L. H. (1978) J. Mol. Biol. 123, 35-47.
3. Alexander, R. S., Nair, S. K., & Christianson, D. W. (1991) Biochemistry 30, 11064-11072.
4. Allen, F. H., Bellard, S., Brice, M. D., Cartwright, B. A., Higgs, H., Hummelink, T., Hummelink-Peters, B. G., Kennard, O., Motherwell, W. D. S., Rodgers, J. R., & Watson, D. G. (1979) Acta Crystallogr., Sect. B 35, 2331-2339.
5. Bernstein, F. C., et al. (1977) J. Mol Biol. 112, 535-542.
6. Browner, M. F., Fauman, E. B., & Fletterick, R. J. (1992) Biochemistry 31, 11297-11304.
7. Browner, M. F., Hackos, D., & Fletterick, R. (1994) Struct. Biol. 1, 327-333.
8. Brunger, A. T., Kuriyan, J., & Karplus, M. (1987) Science 235, 458-460.
9. Chakrabarti, P. (1990) Protein Eng. 4, 57-63.
10. Chambers, J. L., Cristoph, G. G., Krieger, M., Kay, L., & Stroud, R. M. (1974) Biochem. Biophys. Res. Commun. 59, 70-74.
11. Christianson, D. W. (1991) Adv. Protein Chem. 42, 281-355.
12. Fuh, G., & Wells, J. A. (1995) J. Biol. Chem. 270, 13133-13137.
13. Glusker, J. P. (1991) Adv. Protein Chem. 42, 1-75.
14. Guss, J. M., & Freeman, H. C. (1983) J. Mol. Biol. 169, 521-563.
15. Guss, J. M., Harrowell, P. R., Murata, M., Norris, V. A., & Freeman, H. C. (1986) J. Mol. Biol. 192, 361-387.
16. Hakansson, K., Carlsson, M., Svensson, L. A., & Liljas, A. (1992) J. Mol. Biol. 227, 1192-1204.
17. Halfon, S., & Craik, C. S. (1996) J. Am. Chem. Soc. (in press).
18. Hall, T. M. T., Porter, J. A., Beachy, P. A., & Leahy, D. J. (1995) Nature 378, 212-216.
19. He, G. P., Muise, A., Li, A. W., & Ro, H. S. (1995) Nature 378, 92-96.
20. Higaki, J. N., Haymore, B. L., Chen, S., Fletterick, R. J., & Craik, C. S. (1990) Biochemistry 29, 8582-8586.
21. Ibers, J. A., & Holm, R. H. (1980) Science 209, 223-235.
22. Ippolito, J. A., & Christianson, D. W. (1994) Biochemistry 33, 15241-15249.
23. Jabri, E., Carr, M. B., Hausinger, R. P., & Karplus, P. A. (1995) Science 265, 998-1004.
24. Lesburg, C. A., & Christianson, D. W. (1995) J. Am. Chem. Soc. 117, 6838-6844.
25. Martell, A. D., & Smith, R. M. (1974) Critical Stability Constants, Plenum Press, New York.
26. McGrath, M. E., Haymore, B. L., Summers, N. L., Craik, C. S., & Fletterick, R. J. (1993) Biochemistry 32, 1914-1919.
27. McGrath, M. E., Erpel, T., Bystroff, C., & Fletterick, R. J. (1994) EMBO J. 13, 1502-1507.
28. McPherson, A. (1989) Preparation and Analysis of Protein Crystals, Robert E. Kreiger Publishing Co., Malabar, FL.
29. Navaza, J. (1994) Acta Crystallogr. A 50, 157-163.
30. Norris, G. E., Anderson, B. F., & Baker, E. N. (1983) J. Mol. Biol. 165, 501-521.
31. Norris, G. E., Anderson, B. P., & Baker, E. N. (1986) J. Am. Chem. Soc. 108, 2784-2785.
32. Otwinowski, Z. (1990) HKL, Yale University, New Haven, CT.
33. Ponder, J. W., & Richards, F. M. (1987) J. Mol. Biol. 193, 775-791.
34. Quiocho, F. A., & Lipscomb, W. N. (1971) Adv. Protein Chem. 25, 1-78.
35. Rees, D. C., Lewis, M., & Lipscomb, W. N. (1983) J. Mol. Biol. 168, 367-387.
36. Regan, L. (1995) Trends Biochem. Sci. 20, 280-285.
37. Roberts, V. A., Iverson, B. L., Iverson, S. A., Benkovic, S. J., Lerner, R. A., Getzoff, E., D., & Tainer, J. A. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 6654-6658.
38. Sack, J. S. (1988) J. Mol. Graphics 6, 224-225.
39. Schneider, G., Eklund, H., & Cetergren-Zeppezauer, M. (1983) Proc. Natl. Acad. Sci. U.S.A. 80, 5289-5293.
40. Somers, W., Ultsc, M., De Vos, A. M., & Kossiakoff, A. A. (1994) Nature 372, 478-481.
41. Willett, W. S., Gillmor, S., Perona, J. J., Fletterick, R. J., & Craik, C. S. (1995) Biochemistry 34, 2172-2180.
42. Willett, W. S., Brinen, L. S., Fletterick, R. J., & Craik, C. S. (1996) Biochemistry 35, 5992-5998.
43. Yagami-Hiromasa, T., Sato, T., Kurisaki, T., Kamijo, K., Nabeshima, Y., & Fujisaww-Sehara, A. (1995) Nature 377, 652-656.