Calcium phosphate embedded PLGA nanoparticles: A promising gene delivery vector with high gene loading and transfection efficiency

International Journal of Pharmaceutics

Volumn 431, Issue 1-2, 2012, Pages 210-221

  Tang, Jie ^a   Chen, Jin Ying ^a   Liu, Jing ^a   Luo, Min ^a   Wang, Ying Jing ^a   Wei, Xia Wei ^a   Gao, Xiang ^a   Wang, Bi Lan ^a   Liu, Yi Bo ^a   Yi, Tao ^a,b   Tong, Ai Ping ^a   Song, Xiang Rong ^a   Xie, Yong Mei ^a   Zhao, Yinglan ^a   Xiang, Mingli ^a   Huang, Yuan ^a   Zheng, Yu ^a  

^a SICHUAN UNIVERSITY   (China)

^b SICHUAN UNIVERSITY   (China)

Author keywords

Calcium phosphate; CaPi pDNA PLGA NPs; HEK293; Plasmid DNA; PLGA nanoparticle

Indexed keywords

CALCIUM PHOSPHATE; NANOPARTICLE; PHOSPHATE; PLASMID DNA; POLYGLACTIN; POLYVINYL ALCOHOL;

ARTICLE; CHEMICAL INTERACTION; CONTROLLED STUDY; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG RELEASE; GENE TARGETING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; KIDNEY CELL; MOLECULAR WEIGHT; PARTICLE SIZE; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; ULTRASOUND;

CALCIUM PHOSPHATES; CALORIMETRY, DIFFERENTIAL SCANNING; DNA; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; LACTIC ACID; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; PARTICLE SIZE; POLYGLYCOLIC ACID; POROSITY; SURFACE PROPERTIES; TRANSFECTION; X-RAY DIFFRACTION;

EID: 84861338413     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.04.046     Document Type: Article

References (48)

1. C. Aral, and J. Akbuga Preparation and in vitro transfection efficiency of chitosan microspheres containing plasmid DNA:poly(l-lysine) complexes J. Pharm. Pharm. Sci. 6 2003 321 326
2. U. Bilati, E. Allémann, and E. Doelker Sonication parameters for the preparation of biodegradable nanocapsules of controlled size by the double emulsion method Pharm. Dev. Technol. 3 2003 1 9
3. V.A. Bloomfield DNA condensation by multivalent cations Biopolymer 44 1997 269 282
4. J.S. Blum, and W.M. Saltzman High loading efficiency and tunable release of plasmid DNA encapsulated in submicron particles fabricated from PLGA conjugated with poly-L-lysine J. Control. Release 129 2008 66 72
5. R. Bodmeier, and J.W. McGinity Polylactic acid microspheres containing quinidine base and quinidine sulphate prepared by the solvent evaporation method. III. Morphology of the microspheres during dissolution studies J. Microencapsul. 5 1988 325 330
6. E.A.F. Coelho, C.A.P. Tavares, K.D. Lima, C.L. Silva, J.M. Rodrigue, and A.P. Fernandes Mycobacterium hsp65 DNA entrapped into TDM-loaded PLGA microspheres induces protection in mice against Leishmania (Leishmania) major infection Parasitol. Res. 98 2006 568 575
7. K.S. Denis-Mize, M. Dupuis, M. Singh, C. Woo, M. Ugozzoli, D.T. O'Hagan 3rd., J.J. Donnelly, G. Ott, and D.M. McDonald Mechanisms of increased immunogenicity for DNA-based vaccines adsorbed onto cationic microparticles Cell. Immunol. 225 2003 12 22
8. X. Gao, K.S. Kim, and D. Liu Nonviral gene delivery: what we know and what is next AAPS J. 9 2007 E92 E104
9. X. He, L. Jiang, F. Wang, Z. Xiao, J. Li, L.S. Liu, D. Li, D. Ren, X. Jin, K. Li, Y. He, K. Shi, Y. Guo, Y. Zhang, and S. Sun Augmented humoral and cellular immune responses to hepatitis B DNA vaccine adsorbed onto cationic microparticles J. Control. Release 107 2005 357 372
10. X.W. He, F. Wang, L. Jiang, J. Li, S.K. Liu, Z.Y. Xiao, X.Q. Jin, Y.N. Zhang, Y. He, K. Li, Y.J. Guo, and S.H. Sun Induction of mucosal and systemic immune response by single-dose oral immunization with biodegradable microparticles containing DNA encoding HBsAg J. Gen. Virol. 86 2005 601 610
11. M.L. Hedley Formulations containing poly(lactide-co-glycolide) and plasmid DNA expression vectors Expert Opin. Biol. Ther. 3 2003 903 910
12. P.D. Hong, C.M. Chou, and C.H. He Solvent effects on aggregation behavior of polyvinyl alcohol solutions Polymer 42 2001 6105 6112
13. R. Ian, B. Steven, E.H. Nicholas, and A.P. Richard Influence of processing method on the exfoliation process for organically modified clay systems. I. polyurethanes J. Appl. Polym. Sci. 91 2002 1335 1343
14. H. Kimoto, and A. Taketo Studies on electrotransfer of DNA into Escherichia coli: effect of molecular form of DNA Biochim. Biophys. Acta 1307 1996 325 330
15. H.-Y. Kwon, J.-Y. Lee, S.-W. Choi, Y. Jang, and J.-H. Kim Preparation of PLGA nanoparticles containing estrogen by emulsification-diffusion method Colloids Surf. A 182 2001 123 130
16. V. Labhasetwar, J. Bonadio, S. Goldstein, and R.J. Levy Gene transfection using biodegradable nanospheres: results in tissue culture and a rat osteotomy model Colloids Surf. B: Biointerfaces 16 1999 281 290
17. F.D. Ledley Pharmaceutical approach to somatic gene therapy Pharm. Res. 13 1996 1595 1614
18. M.S. Levy, C.W. Sorrels, C.W. Wagner, R.J. Jackson, R.W. Barnes, and S.D. Smith Evolution of the modified Rossetti fundoplication in children: surgical technique and results Ann. Surg. 229 1999 774 779
19. K. Lewandowska, D.U. Staszewska, and M. Bohdanecky The Huggins viscosity coefficient of aqueous solution of poly(vinyl alcohol) Eur. Polym. J. 37 2001 25 32
20. H. Li, W. Zhang, W. Xu, and X. Zhang Hydrogen bonding governs the elastic properties of poly(vinyl alcohol) in water, single molecule force spectroscopic studies of PVA by AFM Macromolecules 33 2000 465 469
21. Y. Li, M. Ogris, J. Pelisek, and M.W. Röedl Stability and release characteristics of poly(d,l-lactide-co-glycolide) encapsulated CaPi-DNA coprecipitation Int. J. Pharm. 269 2004 61 70
22. K.M. Lima, S.A. Santos, V.M.F. Lima, A.A.M. Coelho-Castelo, J.M. Rodrigues, and C.L. Silva Single dose of a vaccine based on DNA encoding mycobacterial hsp65 protein plus TDM-loaded PLGA microspheres protects mice against a virulent strain of Myco-bacterium tuberculosis Gene Ther. 10 2003 678 685
23. A. Loyter, G. Scangos, D. Juricek, D. Keene, and F.H. Ruddle Mechanisms of DNA entry into mammalian cells. II. Phagocytosis of calcium phosphate DNA co-precipitate visualized by electron microscopy Exp. Cell Res. 139 1982 223 234
24. J. Luten, C.F. van Nostrum, S.C. De Smedt, and W.E. Hennink Biodegradable polymers as non-viral carriers for plasmid DNA delivery J. Control. Release 126 2007 97 110
25. S.W. Lyoo, S.I. Seo, C.B. Ji, H.J. Kim, S.S. Kim, D.H. Ghim, C.B. Kim, and J. Lee Role of the stereosequences of poly(vinyl alcohol) in the rheological properties of syndiotacticity-rich poly-(vinyl alcohol)/water solutions J. Appl. Polym. Sci. 88 2003 1858 1863
26. V. Lemaire, J. Bélair, and P. Hildgen Structural modeling of drug release from biodegradable porous matrices based on a combined diffusion/erosion process Int. J. Pharm. 258 2003 95 107
27. R.M. Mainardes, and R.C. Evangelista PLGA nanoparticles containing praziquantel: effect of formulation variables on size distribution Int. J. Pharm. 290 2005 137 144
28. J. Navarro, N. Oudrhiri, S. Fabrega, and P. Lehn Gene delivery systems: bridging the gap between recombination viruses and artificial vectors Adv. Drug Deliv. Rev. 30 1998 5 11
29. T. Niwa, H. Takeuchi, T. Hino, N. Kunou, and Y. Kawashima Preparations of biodegradable nanospheres of water-soluble and insoluble drugs with d,l-lactide/glycolide copolymer by a novel spontaneous emulsification solvent diffusion method, and the drug release behavior J. Control. Release 25 1993 89 98
30. T. Niwa, H. Takeuchi, T. Hino, N. Kunou, and Y. Kawashima In vitro drug release behavior of d,l-lactide/glycolide copolymer (PLGA) nanospheres with nafarelin acetate prepared by a novel spontaneous emulsification solvent diffusion method J. Pharm. Sci. 83 1994 727 732
31. T. Ochiya, S. Nagahara, A. Sano, H. Itoh, and M. Terada Biomaterials for gene delivery: atelocollagen-mediated controlled release of molecular medicines Curr. Gene Ther. 1 2001 31 52
32. E. Orrantia, and P.L. Chang Intracellular distribution of DNA internalized through calcium phosphate precipitation Exp. Cell Res. 190 1990 170 174
33. C.E. Pedraza, D.C. Bassett, M.D. McKee, V. Nelea, U. Gbureck, and J.E. Barralet The importance of particle size and DNA condensation salt for calcium phosphate nanoparticle transfection Biomaterials 29 2008 3384 3392
34. R. Rago, J. Mitchen, and G. Wilding DNA fluorometric assay in 96-well tissue culture plates using Hoechst 33258 after cell lysis by freezing in distilled water Anal. Biochem. 191 1990 31 34
35. X. Song, Y. Zhao, W. Wu, Y. Bi, Z. Cai, Q. Chen, Y. Li, and S. Hou PLGA nanoparticles simultaneously loaded with vincristine sulfate and verapamil hydrochloride: systematic study of particle size and drug entrapment efficiency Int. J. Pharm. 350 2008 320 329
36. V.V. Sokolova, I. Radtke, R. Heumann, and M. Epple Effective transfection of cells with multi-shell calcium phosphate-DNA nanoparticles Biomaterials 27 2006 3147 3153
37. T. Tagawa, M. Manvell, N. Brown, M. Keller, E. Perouzel, K.D. Murray, R.P. Harbottle, M. Tecle, F. Booy, M.C. BrahimiHorn, C. Coutelle, N.R. Lemoine, E.W. Alton, and A.D. Miller Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus corepeptide μ (mu) and plasmid DNA Gene Ther. 9 2002 564 576
38. A.M. Tinsley-Bown, R. Fretwell, A.B. Dowsett, S.L. Davis, and G.H. Farrar Formulation of poly(d,l-lactic-co-glycolic acid) microparticles for rapid plasmid DNA delivery J. Control. Release 66 2000 229 241
39. P. Van de Wetering, J.Y. Cherng, H. Talsma, D.J.A. Crommelin, and W.E. Hennink 2-(Dimethylamino)ethyl methacrylate based (co)polymers as gene transfer agents J. Control. Release 53 1998 145 153
40. E. Walter, D. Dreher, M. Kok, L. Thiele, S.G. Kiama, P. Gehr, and H.P. Merkle Hydrophilic poly(dl-lactide-co-glycolide) microspheres for the delivery of DNA to human-derived macrophages and dendritic cells J. Control. Release 76 2001 149 168
41. E. Walter, K. Moelling, J. Pavlovic, and H.P. Merkle Microencapsulation of DNA using poly(dl-lactide-co-glycolide): stability issues and release characteristics J. Control. Release 61 1999 361 374
42. D. Wang, D.R. Robinson, G.S. Kwon, and J. Samuel Encapsulation of plasmid DNA in biodegradable poly(d,l-lactic-co-glycolic acid) microspheres as a novel approach for immuno-gene delivery J. Control. Release 57 1999 9 18
43. T.D. Xie, L. Sun, H.G. Zhao, J.A. Fuchs, and T.Y. Tsong Study of mechanisms of electric field-induced DNA transfection. IV. Effects of DNA topology on cell uptake and transfection efficiency Biophys. J. 63 1992 1026 1031
44. Y. Yeo, and K. Park Control of encapsulation efficiency and initial burst in polymeric microparticle systems Arch. Pharm. Res. 27 2004 1 24
45. Y.W. Yang, and J.C. Yang Calcium phosphate as a gene carrier: electron microscopy Biomaterials 18 1997 213 217
46. W. Zauner, N.A. Farrow, and A.M. Haines In vitro uptake of polystyrene microspheres: effect of particle size, cell line and cell density J. Control. Release 71 2001 39 51
47. G. Zhu, S.R. Mallery, and S.P. Schwendeman Stabilization of proteins encapsulated in injectable poly (lactide-co-glycolide) Nat. Biotechnol. 18 2000 52 57
48. N. Kofler, C. Ruedl, J. Klima, H. Recheis, G. Böck, G. Wick, and H. Wolf Preparation and characterization of poly-(d,l-lactide-co-glycolide) and poly-(l-lactic acid)microspheres with entrapped pneumotropic bacterial antigens J. Immunol. Methods 192 1996 25 35