Stability and release characteristics of poly(D,L-lactide-co-glycolide) encapsulated CaPi-DNA coprecipitation

International Journal of Pharmaceutics

Volumn 269, Issue 1, 2004, Pages 61-70

  Li, Yaping ^a,b   Ogris, Manfred ^a   Pelisek, Jaroslave ^a   Röedl, Wolfgang ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Calcium phosphate coprecipitation; Microparticles; pDNA; Poly(lactide co glycolide); Stability

Indexed keywords

ACETIC ACID ETHYL ESTER; CALCIUM PHOSPHATE; DICHLOROMETHANE; DNA; HEXANE; NUCLEASE; POLYGLACTIN; POLYVINYL ALCOHOL;

ARTICLE; DNA DEGRADATION; DRUG RELEASE; DRUG STABILITY; EMULSION; MICROENCAPSULATION; PH; PRIORITY JOURNAL;

EID: 0348048802     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2003.08.019     Document Type: Article

References (25)

1. Ando S., Putnam D., Pack D.W., Langer R. PLGA microspheres containing plasmid DNA: preservation of supercoiled DNA via cryopreparation and carbohydrate stabilization. J. Pharm. Sci. 88:1999;126-130.
2. Batard P., Jordan M., Wurm F. Transfer of high copy number plasmid into mammalian cells by calcium phosphate transfection. Gene. 270:2001;61-68.
3. Capan Y., Woo B.H., Gebrekidan S., Ahmed S., DeLuca P.P. Influence of formulation parameters on the characteristics of poly(D,L-lactide-co-glycolide) microspheres containing poly(L-lysin) complexed plasmid DNA. J. Control. Rel. 60:1999a;279-286.
4. Capan Y., Woo B.H., Gebrekidan S., Ahmed S., DeLuca P.P. Preparation and characterization of poly(D,L-lactide-co-glycolide) microspheres for controlled release of poly(L-lysin) complexed plasmid DNA. Pharm. Res. 16:1999b;509-513.
5. Cemazar M., Sersa G., Wilson J., Tozer G.M., Hart S.L., Grosel A., Dachs G.U. Effective gene transfer to solid tumors using different nonviral gene delivery techniques: electroporation, liposomes, and integrin-targeted vector. Cancer Gene Ther. 9:2002;399-406.
6. Hasegawa S., Hirashima N., Nakanishi M. Comparative study of transfection efficiency of cationic cholesterols mediated by liposomes-based gene delivery. Bioorg. Med. Chem. Lett. 12:2002;1299-1302.
7. Hedley M.L., Curley J., Urban T. Microspheres containing plasmid-encoded antigens elicit cytotoxic T-cell response. Nat. Med. 4:1998;365-368.
8. Hirosue S., Muller B.G., Mulligan R.C., Langer R. Plasmid DNA encapsulation and release from solvent diffusion nanoparticles. J. Control. Rel. 70:2001;231-242.
9. Jones D.H., Corris S., McDonald S., Clegg J.C.S., Farrar G.H. Poly(D,L-lactide-co-glycolide)-encapsulated plasmid DNA elicits systemic and mucosal antibody response to encodes protein after oral administration. Vaccine. 15:1997;414-517.
10. Jeong J.H., Park T.G. Novel polymer-DNA hybrid polymeric micelles composed of hydrophobic poly(D,L-lactic-co-glycolic acid) and hydrophilic oligonucleotides. Bioconjug. Chem. 12:2001;917-923.
11. Kircheis R., Wightman L., Wagner E. Design and gene delivery activity of modified polyethylenimines. Adv. Drug Del. Rev. 53:2001;341-358.
12. Luo D., Woodrow-Mumford K., Belcheva N., Saltzman W.M. Controlled DNA delivery systems. Pharm. Res. 16:1999;1300-1308.
13. McKeever U., Barman S., Hao T., Chambers P., Song S., Lunsford L., Hsu Y.Y., Roy K., Hedley M.L. Protective immune responses elicited in mice by immunization with formulations of poly(lactide-co-glycolide) microparticles. Vaccine. 20:2002;1524-1531.
14. Middaugh C.R., Evans R.K., Montgomery D.L., Casimiro D.R. Analysis of plasmid DNA from a pharmaceutical perspective. J. Pharm. Sci. 87:1998;130-146.
15. Schreiber S., Kampgen E., Wagner E., Pirkhammer D., Trcka J., Korschan H., Lindemann A. Immunotherapy of metastatic malignant melanoma by a vaccine consisting of autologous interleukin 2-transfected cancer cells: outcome of a Phase I Study. Hum. Gene Ther. 10:1999;983-993.
16. Seemann S., Hauff P., Schultze-Mosgau M., Lehmann C., Reszka R. Pharmaceutical evaluation of gas-filled microparticles as gene delivery system. Pharm. Res. 19:2002;250-257.
17. Tagawa T., Manvell M., Brown N., Keller M., Perouzel E., Murray K.D., Harbottle R.P., Tecle M., Booy F., Brahimi-Horn M.C., Coutelle C., Lemoine N.R., Alton E.W., Miller A.D. Characterisation of LMD virus-like nanoparticles self-assembled from cationic liposomes, adenovirus core peptide μ (mu) and plasmid DNA. Gene Ther. 9:2002;564-576.
18. Thomasin C., Corradin G., Men Y., Merkle H.P., Gander B. Tetanus toxoid and synthetic malaria antigen containing poly(lactide)/poly(lactide-co- glycolide) microspheres: importance of polymer degradation and antigen release for immune response. J. Control. Rel. 41:1996;131-145.
19. Vandervoort J., Ludwig A. Biocompatible stabilizers in the preparation of PLGA nanoparticles: a factorial design study. Int. J. Pharm. 238:2002;77-92.
20. Van de Wetering P., Cherng J.Y., Talsma H., Crommelin D.J.A., Hennink W.E. 2-(Dimethylamino)ethyl methacrylate based (co)polymers as gene transfer agents. J. Control. Rel. 53:1998;145-153.
21. Wang D., Robinson D.R., Kwon G.S., Samuel J. Encapsulation of plasmid DNA in biodegradable poly(D,L-lactic-co-glycolic acid) microspheres as a novel approach for immuno-gene delivery. J. Control. Rel. 57:1999;9-18.
22. Walter E., Dreher D., Kok M., Thiele L., Kiama S.G., Gehr P., Merkle H.P. Hydrophilic poly(D,L-lactide-co-glycolide) microspheres for the delivery of DNA to human-derived macrophages and dendritic cells. J. Control. Rel. 76:2001;149-168.
23. Walter E., Merkle H.P. Microparticle-mediated transfection of non-phagocytic cells in vitro. J. Drug Target. 10:2002;11-21.
24. Walter E., Moelling K., Pavlovic J., Merkle H.P. Microencapsulation of DNA using poly(D,L-lactide-co-glycolide): stability issues and release characteristics. J. Control. Rel. 61:1999;361-374.
25. Yang Y.W., Yang J.C. Calcium phosphate as a gene carrier: electron microscopy. Biomaterials. 18:1997;213-217.