Preparation and evaluation of granules with pH-dependent release by melt granulation

International Journal of Pharmaceutics

Volumn 431, Issue 1-2, 2012, Pages 70-77

  Shiino, Kai ^a   Iwao, Yasunori ^a   Fujinami, Yukari ^a   Itai, Shigeru ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Aminoalkyl methacrylate copolymer E; Granules properties; Melt granulation; pH dependent release behavior

Indexed keywords

AMINOALKYL METHACRYLATE COPOLYMER E; PARACETAMOL; POLYMER; UNCLASSIFIED DRUG;

ARTICLE; COMPRESSION; DRUG FORMULATION; DRUG GRANULATION; DRUG GRANULE; DRUG RELEASE; DRUG SOLUBILITY; IN VITRO STUDY; PARTICLE SIZE; PH; PRIORITY JOURNAL; TEMPERATURE;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; DRUG COMPOUNDING; GLYCERIDES; HOT TEMPERATURE; HYDROGEN-ION CONCENTRATION; PARTICLE SIZE; POLYMETHACRYLIC ACIDS; WAXES;

EID: 84861334534     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.04.031     Document Type: Article

References (26)

1. P. Bukovec, V. Krošelj, S. Turk, and F. Vrečer Optimization of melt pelletization in a high shear mixer Int. J. Pharm. 381 2009 192 198
2. M. Cerea, W. Zheng, C.R. Young, and J.W. McGinity A novel powder coating process for attaining taste masking and moisture protective films applied to tablets Int. J. Pharm. 279 2004 127 139
3. H.J. Cheng, and S.S. Hsiau The study of granular agglomeration mechanism Powder Technol. 199 2010 272 283
4. R.J. Chokshi, H.K. Sandhu, R.M. Iyer, N.H. Shah, A.W. Malick, and H. Zia Characterization of physico-mechanical properties of indomethacin and polymers to assess their suitability for hot-melt extrusion process as a means to manufacture solid dispersion/solution J. Pharm. Sci. 94 2005 2463 2474
5. FDA, 1997. Center for Drug Evaluation and Research, Guidance for Industry: Dissolution Testing of Immediate Release Solid Oral Dosage Forms.
6. M. Grassi, D. Voinovich, M. Moneghini, E. Franceschinis, B. Perissutti, and J. Filipovic-Grcic Preparation and evaluation of a melt pelletised paracetamol/stearic acid sustained release delivery system J. Control. Release 88 2003 381 391
7. A. Gryczke, S. Schminke, M. Maniruzzaman, J. Beck, and D. Douroumis Development and evaluation of orally disintegrating tablets (ODTs) containing Ibuprofen granules prepared by hot melt extrusion Colloids Surf. B: Biointerfaces 86 2011 275 284
8. J. Hamdani, A.J. Moës, and K. Amighi Development and evaluation of prolonged release pellets obtained by the melt pelletization process Int. J. Pharm. 245 2002 167 177
9. Y. Hiramatsu, and Y. Oka Determination of the tensile strength of rock by a compression test of an irregular test piece Int. J. Rock Mech. Min. Sci. Geomech. Abstr. 3 1966 89 90
10. A. Kramar, S. Turk, and F. Vrečer Statistical optimisation of diclofenac sustained release pellets coated with polymethacrylic films Int. J. Pharm. 256 2003 43 52
11. H. Kranz, and S. Gutsche Evaluation of the drug release patterns and long term stability of aqueous and organic coated pellets by using blends of enteric and gastrointestinal insoluble polymers Int. J. Pharm. 380 2009 112 119
12. V. Krošelj, R. Pišek, and F. Vrečer Production and characterization of immediate release lansoprazole pellets produced by melt pelletization Pharm. Ind. 70 2008 147 155
13. J.W. Moore, and H.H. Flanner Mathematical comparison of dissolution profiles Pharm. Technol. 20 1996 64 74
14. ® E prepared by hot-melt extrusion using thermal microthermal and spectroscopic analysis Int. J. Pharm. 354 2008 158 167
15. T. Schæfer Growth mechanisms in melt agglomeration in high shear mixers Powder Technol. 117 2001 68 82
16. T. Schaefer, P. Holm, and H.G. Kristensen Melt granulation in a laboratory scale high shear mixer Drug Dev. Ind. Pharm. 16 1990 1249 1277
17. T. Schæfer, and C. Mathiesen Melt pelletization in a high shear mixer: IX. Effects of binder particle size Int. J. Pharm. 139 1996 139 148
18. K. Shiino, Y. Iwao, A. Miyagishima, and S. Itai Optimization of a novel wax matrix system using aminoalkyl methacrylate copolymer E and ethylcellulose to suppress the bitter taste of acetaminophen Int. J. Pharm. 395 2010 71 77
19. F. Siepmann, J. Siepmann, M. Walther, R.J. MacRae, and R. Bodmeier Polymer blends for controlled release coatings J. Control. Release 125 2008 1 15
20. L.J. Thomsen, T. Schæfer, and H.G. Kristensen Prolonged release matrix pellets prepared by melt pelletization: II. Hydrophobic substances as meltable binders Drug Dev. Ind. Pharm. 20 1994 1179 1197
21. L.J. Thomsen, T. Schæfer, J.M. Sonnergaard, and H.G. Kristensen Prolonged release matrix pellets prepared by melt pelletization: I. Process variables Drug Dev. Ind. Pharm. 19 1993 1867 1887
22. D. Voinovich, M. Moneghini, B. Perissutti, and E. Franceschinis Melt pelletization in high shear mixer using a hydrophobic melt binder: influence of some apparatus and process variables Eur. J. Pharm. Biopharm. 52 2001 305 313
23. J. Xu, L.L. Bovet, and K. Zhao Taste masking microspheres for orally disintegrating tablets Int. J. Pharm. 359 2008 63 69
24. T. Yajima, A. Nogata, M. Demachi, N. Umeki, S. Itai, N. Yunoki, and M. Nemoto Particle design for taste-masking using a spray-congealing technique Chem. Pharm. Bull. (Tokyo) 44 1996 187 191
25. F. Zhou, C. Vervaet, and J.P. Remon Matrix pellets based on the combination of waxes starches and maltodextrins Int. J. Pharm. 133 1996 155 160
26. F. Zhou, C. Vervaet, and J.P. Remon Influence of processing on the characteristics of matrix pellets based on microcrystalline waxes and starch derivatives Int. J. Pharm. 147 1997 23 30