Optimization of a novel wax matrix system using aminoalkyl methacrylate copolymer E and ethylcellulose to suppress the bitter taste of acetaminophen

International Journal of Pharmaceutics

Volumn 395, Issue 1-2, 2010, Pages 71-77

  Shiino, Kai ^a   Iwao, Yasunori ^a   Miyagishima, Atsuo ^a   Itai, Shigeru ^a  

^a UNIVERSITY OF SHIZUOKA   (Japan)

Author keywords

Acetaminophen; Aminoalkyl methacrylate copolymer E; Ethylcellulose; Multiple regression analysis; Principle component analysis; Taste masking

Indexed keywords

AMINOMETHACRYLATE COPOLYMER E; COPOLYMER; ETHYL CELLULOSE; GLYCEROL STEARATE; PARACETAMOL; UNCLASSIFIED DRUG; WAX; ACYLGLYCEROL; ANALGESIC AGENT; CELLULOSE; DRUG DOSAGE FORM; EUDRAGIT E PO; EXCIPIENT; POLYMETHACRYLIC ACID DERIVATIVE;

ARTICLE; BITTER TASTE; DRUG DESIGN; DRUG FORMULATION; DRUG RELEASE; MULTIPLE REGRESSION; PARTICLE SIZE; PH; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; VISCOSITY; ANALOGS AND DERIVATIVES; CHEMICAL MODEL; CHEMISTRY; DRUG DOSAGE FORM; KINETICS; MEDICINAL CHEMISTRY; PERCEPTION; PHARMACEUTICS; PROCEDURES; REGRESSION ANALYSIS; SOLUBILITY; TASTE;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DOSAGE FORMS; DRUG COMPOUNDING; EXCIPIENTS; GLYCERIDES; HYDROGEN-ION CONCENTRATION; KINETICS; MODELS, CHEMICAL; PARTICLE SIZE; PERCEPTUAL MASKING; POLYMETHACRYLIC ACIDS; PRINCIPAL COMPONENT ANALYSIS; REGRESSION ANALYSIS; SOLUBILITY; TASTE; TECHNOLOGY, PHARMACEUTICAL; VISCOSITY; WAXES;

EID: 77954309105     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2010.05.007     Document Type: Article

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